A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines

Experimental Cell Research

Volumn 270, Issue 2, 2001, Pages 277-288

  Blajeski, April L ^a   Kottke, Timothy J ^b   Kaufmann, Scott H ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Apoptosis; MDA MB 468; Multinucleation; Paclitaxel

Indexed keywords

APHIDICOLIN; BIOCHEMICAL MARKER; CYCLIN E; PACLITAXEL; PROTEIN P21; THYMIDINE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; ELECTRON MICROSCOPY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MICROSCOPY; MITOSIS INHIBITION; PRIORITY JOURNAL; TETRAPLOIDY;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035499794     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5349     Document Type: Article

References (67)

1. The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents
2. cdc2 coincident with Taxol-induced apoptosis
3. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
4. Apoptosis susceptibility of human carcinoma and leukemia cell lines to Taxol: Relationship with cell cycle and drug concentrations
5. Paclitaxel induces programmed cell death in MDA-MB-468 human breast cancer cells
6. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death
7. Dual cytotoxic mechanisms of submicromolar Taxol on human leukemia HL-60 cells
8. Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome c and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells
9. Mechanisms of Taxol-induced cell death are concentration dependent
10. Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis
11. Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
12. Microtubules and actin flaments: Dynamic targets for cancer chemotherapy
13. Taxol and other microtubule-interactive agents
14. The microtubule-affecting drug paclitaxel has antiangiogenic activity
15. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol
16. Paclitaxel (Taxol): An inhibitor of angiogenesis in a highly vascularized transgenic breast cancer
17. Relationship between the structure of Taxol and other taxanes on induction of tumor necrosis factor-alpha gene expression and cytotoxicity
18. Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis
19. Taxol affects nuclear lamina and pore complex organization and inhibits import of karyophilic proteins into the cell nucleus
20. 2-terminal kinase/activator protein 1 pathway and inhibition of extracellular signal-regulated kinase are early effects in paclitaxel-mediated apoptosis in human B lymphoblasts
21. Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells
22. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both ras and apoptosis signal-regulating kinase pathways
23. Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells
24. Direct photoaffinity labeling of tubulin with Taxol
25. Characterization of the Taxol binding site on the microtubule; 2-(m-azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin
26. Taxol stabilizes microtubules in mouse fibroblast cells
27. Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations
28. Taxol suppresses dynamics of individual microtubules in living human tumor cells
29. The spindle assembly checkpoint
30. The spindle checkpoint
31. Paclitaxel-associated multimininucleation is permitted by the inhibition of caspase activation: A potential early step in drug resistance
32. Resistance to paclitaxel induces time-delayed multinucleation and DNA fragmentation into large fragments in MCF-7 human breast adenocarcinoma cells
33. Comparison of paclitaxel-, 5-fluoro-2′-deoxyuridine- and epidermal growth factor-induced apoptosis: Evidence for EGF-induced anoikis
34. Waf1 in mediating inhibition of paclitaxel-induced apoptosis by epidermal growth factor in MDA-MB-468 human breast cancer cells
35. Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells
36. The role of Apaf-1, caspase-9, and Bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis
37. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage
38. Delayed DNA damage associated with mitotic catastrophe following X-irradiation of HeLa S3 cells
39. Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis
40. Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits Taxol-induced apoptosis of human breast cancer MCF-7 cells
41. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
42. Three related centromere proteins are absent from the inactive centromere of a stable isodicentric chromosome
43. Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
44. Histologic fixatives suitable for diagnostic light and electron microscopy
45. A low-viscosity epoxy resin embedding medium for electron microscopy
46. Measurement of protein using bicinchoninic acid
47. Mutations in the p53 gene occur in diverse human tumour types
48. Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene
49. CENP-F is a ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization
50. CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis
51. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
52. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
53. Aphidicolin: A specific inhibitor of nuclear DNA replication in eukaryotes
54. Aphidicolin inhibits eukaryotic DNA replication and repair: Implications for involvement of DNA polymerase alpha in both processes
55. Evaluation of DNA repair inhibition by antitumor or antibiotic drugs using a chemiluminescence microplate assay
56. Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage
57. Mice lacking p21cip1/waf1 undergo normal development, but are defective in G1 checkpoint control
58. p21 is necessary for the p53-mediated G1 arrest in human cancer cells
59. DNA topoisomerase II is required at the time of mitosis in yeast
60. Topoisomerase II: A specific marker for cell proliferation
61. DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe
62. UV radiation is a transcriptional inducer of p21Cip1/Waf1 cyclin-kinase inhibitor in a p53-independent manner
63. Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun and p21Cip1, but independent of p53
64. Involvement of p21 in the PKC-induced regulation of the G2/M cell cycle transition
65. Interruption of NFkappaB-STAT1 signaling mediates EGF-induced cell-cycle arrest
66. Inhibition of human caspases by peptide-based and macromolecular inhibitors