메뉴 건너뛰기




Volumn 7, Issue 4, 2001, Pages 444-451

AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CD14 ANTIGEN; CD34 ANTIGEN; HYBRID PROTEIN; TRANSCRIPTION FACTOR;

EID: 0035047652     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/86515     Document Type: Article
Times cited : (413)

References (45)
  • 1
    • 0024711273 scopus 로고
    • Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein
    • (1989) Genes Dev. , vol.3 , pp. 1146-1156
    • Birkenmeier, E.H.1
  • 7
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 569-574
    • Zhang, D.E.1
  • 8
    • 0031835661 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4301-4314
    • Radomska, H.S.1
  • 9
    • 0033564978 scopus 로고    scopus 로고
    • C/EBPα bypasses granulocyte-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
    • (1999) Blood , vol.94 , pp. 560-571
    • Wang, X.1    Scott, E.2    Sawyers, C.L.3    Friedman, A.D.4
  • 10
    • 0035093813 scopus 로고    scopus 로고
    • Dominant negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
    • (2001) Nature Genet. , vol.27 , pp. 263-270
    • Pabst, T.1
  • 11
    • 0033559746 scopus 로고    scopus 로고
    • Biallelic and heterozygous point mutations in the Runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
    • (1999) Blood , vol.93 , pp. 1817-1824
    • Osato, M.1
  • 12
    • 0027404162 scopus 로고
    • Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia
    • (1993) Blood , vol.81 , pp. 883-888
    • Nucifora, G.1
  • 13
    • 0032830638 scopus 로고    scopus 로고
    • Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia
    • (1999) Nature Genet. , vol.23 , pp. 166-175
    • Song, W.J.1
  • 14
    • 0026757174 scopus 로고
    • Identification of breakpoint in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
    • (1992) Blood , vol.80 , pp. 1825-1831
    • Erickson, P.1
  • 15
    • 0027218725 scopus 로고
    • The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
    • (1993) EMBO J. , vol.12 , pp. 2715-2721
    • Miyoshi, H.T.1
  • 17
    • 0025746321 scopus 로고
    • t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene AML1
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10431-10434
    • Miyoshi, H.1
  • 18
    • 0029616633 scopus 로고
    • The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B
    • (1995) Oncogene , vol.11 , pp. 2667-2674
    • Frank, R.1
  • 19
    • 0028066779 scopus 로고
    • PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBF β proto-oncoproteins, regulates the murine myeloperoxidease and neutrophil elastase genes in immature myeloid cells
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5558-5568
    • Nuchprayoon, L.1
  • 20
    • 0030024112 scopus 로고    scopus 로고
    • CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1231-1240
    • Zhang, D.E.1
  • 21
    • 0031806532 scopus 로고    scopus 로고
    • Multiple functional domains of AML1: PU.1 and C/EBPα synergize with different regions of AML1
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3915-3925
    • Petrovick, M.S.1
  • 22
    • 0027984233 scopus 로고
    • Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8085-8095
    • Zhang, D.E.1
  • 23
    • 0029859199 scopus 로고    scopus 로고
    • Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11895-11900
    • Rhoades, K.L.1
  • 24
    • 0031025416 scopus 로고    scopus 로고
    • Embryonic lethality and impairment of hematopoiesis in mice heterozygous for an AML1-ETO fusion gene
    • (1997) Nature Genet. , vol.15 , pp. 303-306
    • Yergeau, D.A.1
  • 27
    • 0034665765 scopus 로고    scopus 로고
    • Analysis of the role of AML1-ETO in leukemogenesis using an inducible transgenic mouse model
    • (2000) Blood , vol.96 , pp. 2108-2115
    • Rhoades, K.L.1
  • 29
    • 0031972701 scopus 로고    scopus 로고
    • The t(8;21) fusion product, AML-1-ETO, associates with C/EBPα, inhibits C/EBPα-dependent transcription, and blocks granulocytic differentiation
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 322-333
    • Westendorf, J.J.1
  • 30
    • 0025817842 scopus 로고
    • Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation
    • (1991) Blood , vol.77 , pp. 2031-2036
    • Asou, H.1
  • 33
    • 0028798816 scopus 로고
    • Autoregulation of the human C/EBPα gene by stimulation of upstream stimulatory factor binding
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1192-1202
    • Timchenko, N.1
  • 36
    • 0027970838 scopus 로고
    • Chromosomal translocations in human cancer
    • (1994) Nature , vol.372 , pp. 143-149
    • Rabbits, T.H.1
  • 44
    • 0024002556 scopus 로고
    • Luciferase reporter gene vectors for analysis of promoters and enhancers
    • (1988) Biotechniques , vol.6 , pp. 454-458
    • Nordeen, S.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.