The transcriptional control of hematopoiesis

Blood

Volumn 87, Issue 10, 1996, Pages 4025-4039

  Shivdasani, Ramesh A ^a   Orkin, Stuart H ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; GROWTH FACTOR; HELIX LOOP HELIX PROTEIN; HOMEODOMAIN PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

CELL DIFFERENTIATION; CELL GROWTH; EMBRYO DEVELOPMENT; ERYTHROPOIESIS; GENE DISRUPTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HOMEOBOX; LYMPHOPOIESIS; NONHUMAN; ONCOGENE; ORGANOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 0029876726     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.10.4025.bloodjournal87104025     Document Type: Review

References (176)

1. Thomas KR, Capecchi MR: Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503, 1987
2. Mansour S, Thomas K, Capecchi M: Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes. Nature 336:348, 1988
3. Capecchi MR: Altering the genome by homologous recombination. Science 244:1288, 1989
4. Doetschman T, Eistetter H, Katz M, Schmidt W, Kemler R: The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands, and myocardium. J Embryol Exp Morph 87:27, 1985
5. Schmitt RM, Bruyns E, Snodgrass HR: Hematopoietic development of embryonic stem cells in vitro: Cytokine and receptor gene expression. Genes Dev 5:728, 1991
6. Keller G, Kennedy M, Papayannopoulou T, Wiles MV: Hematopoietic differentiation during embryonic stem cell differentiation in culture. Mol Cell Biol 13:472, 1993
7. Weiss M, Orkin SH: In vitro differentiation of embryonic stem cells: New approaches to old problems. J Clin Invest 97:591, 1996
8. Moore MSA, Metcalf D: Ontogeny of the haemopoietic system: Yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol 18:279, 1970
9. Tavassoli M: Embryonic and fetal hemopoiesis: An overview. Blood Cells 1:269, 1991
10. Zon LI: Developmental biology of hematopoiesis. Blood 86:2876, 1995
11. Toles JF, Chui DHK, Belbeck LW, Starr E, Barker JE: Hematopoietic stem cells in murine embryonic yolk sac and peripheral blood. Proc Natl Acad Sci USA 86:7456, 1989
12. Huang H, Auerbach R: Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo. Proc Natl Acad Sci USA 90:10110, 1993
13. Medvinsky AL, Samoylina NL, Muller AM, Dzierzak EA: An early pre-liver intraembryonic source of CFU-S in the developing mouse. Nature 364:64, 1993
14. Godin IE, Garcia-Porrero JA, Coutinho A, Dieterlen-Lievre F, Marcos MAR: Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors. Nature 364:67, 1993
15. Muller AM, Medvinsky A, Strouboulis J, Grosveld F, Dzierzak E: Development of hematopoietic stem cell activity in the mouse embryo. Immunity 1:291, 1994
16. Wu H, Liu X, Jaenisch R, Lodish H: Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83:59, 1995
17. Rudricki MA, Schnegelsberg PNJ, Stead RH, Braun T, Arnold H-H, Jaenisch R: MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75:1351, 1993
18. Villares R, Cabrera CV: The achaete-scute gene complex of D. melanogaster: Conserved domains in a subset of genes required for neurogenesis and their homology to c-myc. Cell 50:415, 1987
19. Lee JE, Hollenberg SM, Snider L, Turner DL, Lipnick N, Weintraub H: Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836, 1995
20. Caudy M, Vassin H, Brand M, Tuma R, Jan LY, Jan YN: daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarity to myc and the achaetescute complex. Cell 55:1061, 1988
21. Murre C, McCaw PS, Baltimore D: A new DNA binding and dimerization motif in immunoglobin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777, 1989
22. Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB, Weintraub H, Baltimore D: Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58:537, 1989
23. Begley CG, Aplan PD, Davey MP, Nakahara K, Tchorz K, Kurtzberg J, Hershfield MS, Haynes BF, Cohen DI, Waldmann TA, Kirsch IR: Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor d-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci USA 86:2031, 1989
24. Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM: Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci USA 86:5039, 1989
25. Xia Y, Brown L, Yang CY-C, Tsna JT, Siciliano MJ, Espinosa R III, LeBeau MM, Baer RJ: Tal2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci USA 88:11416, 1991
26. Mellentin JD, Smith SD, Cleary ML: lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 58:77, 1989
27. Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR: The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc Natl Acad Sci USA 86:10128, 1989
28. Mouthon M-A, Bernard O, Mitjavila M-T, Romeo P-H, Vainchenker W, Mathieu-Mahul D: Expression of tal-1 and GATA-binding proteins during human hematopoiesis. Blood 81:647, 1993
29. Aplan PD, Nakahara K, Orkin SH, Kirsch IR: The SCL gene product: A positive regulator of erythroid differentiation. EMBO J 11:4073, 1992
30. Shivdasani RA, Mayer EL, Orkin SH: Absence of blood formation in mice lacking the T-cell leukemia oncoprotein tal-1/SCL. Nature 373:432, 1995
31. Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey RP, Metcalf D, Begley CG: Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci USA 92:7075, 1995
32. Porcher C, Swat W, Rockwell K, Fujiwara Y, Shivdasani RA, Alt FW, Orkin SH: Complete block to hematopoiesis in the absence of the T-cell leukemia oncoprotein SCL/TAL-1. Blood 86:253a, 1995 (abstr, suppl 1)
33. Chen J, Lansford R, Stewart V, Young F, Alt FW: RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development. Proc Natl Acad Sci USA 90:4528, 1993
34. Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K: Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science 265:103, 1994
35. Metzger D, Clifford J, Chiba H, Chambon P: Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc Natl Acad Sci USA 92:6991, 1995
36. Kuhn R, Schwenk F, Aguet M, Rajewsky K: Inducible gene targeting in mice. Science 269:1427, 1995
37. Kallianpur AR, Jordan JE, Brandt SJ: The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis. Blood 83:1200, 1994
38. Hwang L-Y, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R: Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. Oncogene 8:3043, 1993
39. Lowell CA, Soriano P, Varmus HE: Functional overlap in the src gene family: Inactivation of hck and fgr impairs natural immunity. Genes Dev 8:387, 1994
40. Lieschke GJ, Grail D, Hodgson G, Metcalf D, Stanley E, Cheers C, Fowler KJ, Basu S, Zhan YF, Dunn AR: Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84:1737, 1994
41. Baribault H, Penner J, Iozzo RV, Wilson-Heiner M: Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev 8:2964, 1994
42. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey RJ, Magnuson T: Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 269:230, 1995
43. Sibilia M, Wagner EF: Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234, 1995
44. Boehm T, Foroni L, Kaneko Y, Perutz MP, Rabbits TH: The rhombotin family of cysteine-rich LIM-domain oncogenes: Distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci USA 88:4367, 1991
45. Rabbits TH: Chromosomal translocations in human cancer. Nature 372:143, 1994
46. Warren AJ, Colledge WH, Carlton MBL, Evans MJ, Smith AJH, Rabbits TH: The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development. Cell 78:45, 1994
47. Hsu H-L, Cheng J-T, Chen Q, Baer R: Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol Cell Biol 11:3037, 1991
48. Voronova AF, Lee F: The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation. Proc Natl Acad Sci USA 91:5952, 1994
49. Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbits TH: The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci USA 91:8617, 1994
50. Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbits TH, Baer R: Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J 13:4831, 1994
51. Sadler I, Crawford AW, Michelsen JW, Beckerle MC: Zyxin and cCRP: Two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol 119:1573, 1992
52. Tsai SF, Martin DI, Zon LI, D'Andrea AD, Wong GG, Orkin SH: Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature 339:446, 1989
53. Evans T, Felsenfeld G: The erythroid-specific transcription factor eryf1: A new finger protein. Cell 58:877, 1989
54. Martin DIK, Zon LI, Mutter G, Orkin SH: Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature 344:444, 1990
55. Romeo P-H, Prandini M-H, Joulin V, Mignotte V, Prenant M, Vainchenker W, Marguerie G, Uzan G: Megakaryocytic and erythrocytic lineages share specific transcription factors. Nature 344:447, 1990
56. Zon LI, Yamaguchi Y, Yee K, Albee EA, Kimura A, Bennett JC, Orkin SH, Ackerman SJ: Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: Potential role in gene transcription. Blood 81:3234, 1993
57. Pevny L, Simon MC, Robertson E, Klein WH, Tsai S-F, D'Agati V, Orkin SH, Costantini F: Erythroid differentiation in chimeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349:257, 1991
58. Simon MC, Pevny L, Wiles MV, Keller G, Costantini F, Orkin SH: Rescue of erythroid development in gene targeted GATA-1-mouse embryonic stem cells. Nat Genet 1:92, 1992
59. Weiss MJ, Keller G, Orkin SH: Novel insights into erythroid development revealed through in vitro differentiation of GATA-1-embryonic stem cells. Genes Dev 8:1184, 1994
60. Pevny L, Lin C-S, D'Agati V, Simon MC, Orkin SH, Costantini F: Development of hematopoietic cells lacking transcription factor GATA-1. Development 121:163, 1995
61. Weiss MJ, Orkin SH: Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci USA 92:9623, 1995
62. Lassar AB, Patterson BM, Weintraub H: Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Cell 47:649, 1986
63. Davis RL, Weintraub H, Lassar AB: Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51:987, 1987
64. Visvader JE, Elefanty AG, Strasser A, Adams JM: GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO J 11:4557, 1992
65. Visvader J, Adams JM: Megakaryocytic differentiation induced in 416B myeloid cells by GATA-2 and GATA-3 transgenes or 5-azacytidine is tightly coupled to GATA-1 expression. Blood 82:1493, 1993
66. Kulessa H, Frampton J, Graf T: GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes Dev 9:1250, 1995
67. Suda T, Suda J, Ogawa M: Single-cell origin of mouse hemopoietic colonies expressing multiple lineages in variable combinations. Proc Natl Acad Sci USA 80:6689, 1983
68. Ogawa M: Effects of hemopoietic growth factors on stem cells in vitro. Hematol Clin North Am 3:453, 1989
69. Orkin SH: GATA-binding transcription factors in hematopoietic cells. Blood 80:575, 1992
70. Yamamoto M, Ko LJ, Leonard MW, Beug H, Orkin SH, Engel JD: Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev 4:1650, 1990
71. Dorfman DM, Wilson DB, Bruns GA, Orkin SH: Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J Biol Chem 267:1279, 1992
72. Oosterwegel M, Timmerman J, Leiden J, Clevers H: Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesis. Dev Immunol 3:1, 1992
73. Briegel K, Lim K-C, Plank C, Beug H, Engel J, Zenke M:Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Genes Dev 7:1097, 1993
74. Tsai F-Y, Keller G, Kuo FC, Weiss MJ, Chen J-Z, Rosenblatt M, Alt F, Orkin SH: An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371:221, 1994
75. Chui DHK, Russell ES: Fetal erythropoiesis in steel mutant mice. I. A morphological study of erythroid cell development in fetal liver. Dev Biol 40:256, 1974
76. Ogawa M, Nishikawa S, Yoshinaga K, Hayashi S-I, Kunisada T, Nakao J, Kina T, Sudo T, Kodama H, Nishikawa S-I: Expression and function of c-Kit in fetal hemopoietic progenitor cells: Transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo. Development 117:1089, 1993
77. Pandolfi PP, Roth ME, Karis A, Leonard MW, Dzierzak E, Grosveld FG, Engel JD, Lindenbaum MH: Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat Genet 11:40, 1995
78. Gonda TJ, Sheiness DK, Bishop JM: Transcripts from the cellular homologs of retroviral oncogenes: Distribution among chicken tissues. Mol Cell Biol 2:617, 1982
79. Westin EH, Gallo RC, Arya SK, Eva A, Souza LM, Baluda MA, Aaronson SA, Wong-Staal F: Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci USA 79:2194, 1982
80. Kastan MB, Stone KD, Civin CI: Nuclear oncoprotein expression as a function of lineage, differentiation stage, and proliferation status of normal human hematopoietic cells. Blood 74:1517, 1989
81. Clarke MF, Kukowska-Latallo JF, Westin E, Smith M, Prochownik EV: Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol 8:884, 1988
82. Gewirtz AM, Calabretta B: A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro. Science 242:1303, 1988
83. Radke K, Beug H, Kornfeld S, Graf T: Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene. Cell 31:643, 1982
84. Graf T, McNagny K, Brady G, Frampton J: Chicken "erythroid" cells transformed by the gag-myb-ets-encoding E26 leukemia virus are multipotent. Cell 70:201, 1992
85. Beug H, Blundell P, Graf T: Reversibility of differentiation and proliferative capacity in avian myelomonocytic cells transformed by tsE26 leukemia virus. Genes Dev 1:277, 1987
86. Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott JW Jr, Potter SS: A functional c-myb gene is required for normal fetal hepatic hematopoiesis. Cell 65:677, 1991
87. Badiani P, Corbella P, Kioussis D, Marvel J, Weston K: Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev 8:770, 1994
88. Stegmaier K, Pendse S, Barker GF, Bray-Ward P, Ward DC, Montgomery KT, Krauter KS, Reynolds C, Sklar J, Donnelly M, Bohlander S, Rowley JD, Sallan SE, Gilliland DG, Golub TR: Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood. Blood 86:38, 1995
89. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR: AML-1, the target of multiple chromosomal translocations in human leukemia, is essential for normal murine fetal liver hematopoiesis. Blood 86:596a, 1995 (abstr, suppl 1)
90. Moreau-Gachelin F, Ray D, Tambourin P, Tavitian A, Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA: The Pu. 1 transcription factor is the product of the putative oncogene Spi-1. Cell 61:1166, 1990
91. Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA: The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113, 1990
92. Pahl HL, Scheibe RJ, Zhang D-E, Chen H-M, Galson DL, Maki RA, Tenen DG: The proto-oncogene PU.1 regulates expression of the myeloid-specinc CD11b promoter. J Biol Chem 268:5014, 1993
93. Pongubala JMR, Van Beveren C, Nagulapalli S, JKM, McKercher SR, Maki RA, Atchison ML: Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Science 259:1622, 1993
94. Shin MK, Koshland ME: Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element. Genes Dev 7:2006, 1993
95. Schuetze S, Paul R, Gliniak BC, Kabat D: Role of the PU.1 transcription factor in controlling differentiation of Friend erythroleukemia cells. Mol Cell Biol 12:2967, 1992
96. Galson DL, Hensold JO, Bishop TR, Schalling M, D'Andrea A, Jones C, Auron PE, Housman DE: Mouse b-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol Cell Biol 13:2929, 1993
97. Voso MT, Burn TC, Wulf G, Lim B, Leone G, Tenen DG: Inhibition of hematopoiesis by competitive binding of transcription factor PU.1. Proc Natl Acad Sci USA 91:7932, 1994
98. Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573, 1994
99. Eisenbeis CF, Singh H, Storb U: PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer. Mol Cell Biol 13:6452, 1993
100. Ness SA, Kowens-Leutz E, Casini T, Graf T, Leutz A: Myb and NF-M: Combinatorial activators of myeloid genes in heterologous cell types. Genes Dev 7:749, 1993
101. Eisenbeis CF, Singh H, Storb U: Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev 9:1377, 1995
102. Bories J-C, Willerford DM, Grevin D, Davidson L, Camus A, Martin P, Stehelin D, Alt FW: Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature 377:635, 1995
103. Muthusamy N, Barton K, Leiden JM: Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature 377:639, 1995
104. Orkin SH: Globin gene regulation and switching: Circa 1990. Cell 63:665, 1990
105. Miller IJ, Bieker JJ: A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol 13:2776, 1993
106. Feng WC, Southwood CM, Bieker JJ: Analyses of β-thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an erythroid cell-specific transcription factor. J Biol Chem 269:1493, 1994
107. Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F: Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375:316, 1995
108. Perkins AC, Sharpe AH, Orkin SH: Lethal β-thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375:318, 1995
109. Orkin SH: Transcription factors and hematopoietic development. J Biol Chem 270:4955, 1995
110. Mignotte V, Wall L, deBoer E, Grosveld F, Romeo P-H: Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene. Nucl Acids Res 17:37, 1989
111. Ney PA, Sorrentino BP, Lowrey CH, Nienhuis AW: Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein. Nucl Acids Res 18:6011, 1990
112. Talbot D, Grosveld F: The 5′ HS 2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites. EMBO J 10:1391, 1991
113. Andrews NC, Erjument-Bromage H, Davidson MB, Tempst P, Orkin SH: Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature 362:722, 1993
114. Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH: The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci USA 90:11488, 1993
115. Shivdasani RA, Orkin SH: Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci USA 92:8690, 1995
116. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris C, Orkin SH: Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81:695, 1995
117. Chan JY, Han X-L, Kan YW: Cloning of Nrf 1, an NF-E2-related transcription factor, by genetic selection in yeast. Proc Natl Acad Sci USA 90:11371, 1993
118. Caterina JJ, Donze D, Sun C-W, Ciavatta DJ, Townes TM: Cloning and functional characterization of LCR-F1: A bZIP transcription factor that activates erythroid-specific, human globin gene expression. Nucleic Acids Res 22:2383, 1994
119. Moi P, Chan K, Asunis I, Cao A, Kan YW: Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the β-globin locus control region. Proc Natl Acad Sci USA 91:9926, 1994
120. Chui DHK, Tang W, Orkin SH: cDNA cloning of murine Nrf2 gene, coding for a p45 NF-E2 related transcription factor. Biochem Biophys Res Commun 209:40, 1995
121. Igarashi K, Kataoka K, Itoh K, Hayashi N, Nishizawa M, Yamamoto M: Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. Nature 367:568, 1994
122. Kataoka K, Igarashi K, Itoh K, Fujiwara KT, Noda M, Yamamoto M, Nishizawa M: Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Mol Cell Biol 15:2180, 1995
123. Kotkow, KJ, Orkin SH: Complexity of the erythroid transcription factor NF-E2 as revealed by gene targetting of the mouse p18 NF-E2 locus. Proc Natl Acad Sci USA (in press)
124. Soriano P, Montgomery C, Geske R, Bradley A: Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693, 1991
125. Johnson RS, Spiegelman BM, Papaioannou V: Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71:577, 1992
126. Wang Z-Q, Ovitt C, Grigoriadis AE, Mohle-Steinlein U, Ruther U, Wagner EF: Bone and haematopoietic defects in mice lacking c-fos. Nature 360:741, 1992
127. Ruther U, Komitowski D, Schubert FR, Wagner EF: c-fos expression induces bone tumors in transgenic mice. Oncogene 4:861, 1989
128. Grigoriadis AE, Wang Z-Q, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF: c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266:443, 1994
129. Nguyen HQ, Hoffman-Liebermann B, Liebermann DA: The zinc finger transcription factor egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 72:197, 1993
130. Lee SL, Tourtellotte LC, Wesselschmidt RL, Milbrandt J: Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A. J Biol Chem 270:9971, 1995
131. Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T: Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353, 1995
132. Roberts CWM, Shutter JR, Korsmeyer SJ: Hox11 controls the genesis of the spleen. Nature 368:747, 1994
133. Hatano M, Roberts CWM, Minden M, Crist WM, Korsmeyer SJ: Deregulation of a homeobox gene, HOX11, by the t(10; 14) in T cell leukemia. Science 253:79, 1991
134. Dear TN, Colledge WH, Carlton MBL, Lavenir I, Larson T, Smith AJH, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH: The Hox11 gene is essential for cell survival during spleen development. Development 121:2909, 1995
135. Lawrence HJ, Largman C: Homeobox genes in normal hematopoiesis and leukemias. Blood 80:2445, 1992
136. Perkins AC, Cory S: Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene. EMBO J 12:3835, 1993
137. Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK: Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci USA 91:12223, 1994
138. Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK: Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9:1753, 1995
139. Giampaolo A, Sterpetti P, Bulocrini D, Samoggia P, Pelosi P, Valtieri F, Peschle C: Key functional role and lineage-specific expression of HOXB cluster genes in purified hematopoietic progenitor differentiation. Blood 84:3637, 1994
140. Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR: Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375:791, 1995
141. Yu BD, Hess JL, Horning SE, Brown GAJ, Korsmeyer SJ: Altered Hox expression and segmental identity in M11-mutant mice. Nature 378:505, 1995
142. Georgopoulos K, Morgan BA, Moore DD: Ikaros, an early lymphoid restricted transcription factor, a putative mediator for T cell commitment. Science 258:808, 1992
143. Georgopoulos K, Bigby M, Wang J-H, Molnar A, Wu P, Winandy S, Sharpe A: The Ikaros gene is required for the development of all lymphoid lineages. Cell 79:143, 1994
144. Winandy S, Wu P, Georgopoulos K: A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83:289, 1995
145. Bain G, Maandag ECR, Izon DJ, Amsen D, Kruisbeek A, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M, van der Valk M, te Riele HPJ, Berns A, Murre C: E2A proteins are required for proper B cell development and initiation of immunoglobulin rearrangements. Cell 79:885, 1994
146. Zhuang Y, Soriano P, Weintraub H: The helix-loop-helix gene E2A is required for B cell formation. Cell 79:875, 1994
147. Zhuang Y, Kim C, Bartelmez S, Cheng P-F, Groudine M, Weintraub H: Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, and neurogenesis. Proc Natl Acad Sci USA 89:12132, 1992
148. Staudt LM, Clerc RG, Singh H, LeBowitz JH, Sharp PA, Baltimore D: Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif. Science 241:577, 1988
149. Corcoran LM, Karvelas M, Nossal GJV, Ye Z-S, Jacks T, Baltimore D: Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev 7:570, 1993
150. Konig H, Pfisterer P, Corcoran LM, Wirth T: Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2. Genes Dev 9:1598, 1995
151. Strubin M, Newell JW, Matthias P: OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80:497, 1995
152. Luo Y, Roeder RG: Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol Cell Biol 15:4115, 1995
153. Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens CM: A B-cell coactivator of octamer-binding transcription factors. Nature 373:360, 1995
154. Tanese N, Tjian R: Coactivators and TAFs: A new class of eukaryotic transcription factors that connect activators to the basal machinery. Cold Spring Harb Symp Quant Biol 58:179, 1993
155. Grosschedl R, Giese K, Pagel J: HMG domain proteins: Architectural elements in the assembly of nucleoprotein structures. Trends Genet 10:94, 1994
156. van Genderen C, Okamura RM, Farinas I, Quo R-G, Parslow TG, Bruhn L, Grosschedl R: Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev 8:2691, 1994
157. Verbeek S, Izon D, Hofhuis F, Robanus-Maandag E, te Riele H, van de Wetering M, Oosterwegel M, Wilson A, MacDonald HR, Clevers H: An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374:70, 1995
158. Zuker CS: On the evolution of eyes: Would you like it simple or compound? Science 265:742, 1994
159. Jonsson J, Carlsson L, Edlund T, Edlund H: Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606, 1994
160. Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA, Mulligan RC: Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 264:713, 1994
161. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
162. Shalaby F, Rossant J, Yamaguchi TP, Gertstenstein M, Wu X-F, Breitman ML, Schuh AC: Failure of blood island formation and vasculogenesis in Flk-1-deficient mice. Nature 376:62, 1995
163. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794, 1995
164. Nosaka T, van Deursen JMA, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN: Defective lymphoid development in mice lacking Jak3. Science 270:800, 1995
165. Lee EY-HL, Chang C-Y, Hu N, Wang Y-CJ, Lai C-C, Herrup K, Lee W-H, Bradley A: Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359:288, 1992
166. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA: Effects of an Rb mutation in the mouse. Nature 359:295, 1992
167. Clarke AR, Maandag ER, van Roon M, van der Lugt NMT, van der Valk M, Hooper ML, Berns A, te Riele H: Requirement for a functional Rb-1 gene in murine development. Nature 359:328, 1992
168. Davis AC, Wims M, Spotts GD, Hann SR, Bradley A: A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev 7:671, 1993
169. Leveen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C: Mice deficient for PDGF B show renal, cardiovascular, and hematologic abnormalities. Genes Dev 8:1875, 1994
170. Soriano P: Abnormal kidney development and hematological disorders in PDGF B-receptor mutant mice. Genes Dev 8:1888, 1994
171. Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck R-P, Lira SA, Bravo R: Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80:331, 1995
172. Urbanek P, Wang Z-Q, Fetka I, Wagner E, Busslinger M: Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79:901, 1994
173. Lin H, Grosschedl R: Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376:263, 1995
174. Sha WC, Liou H-C, Tuomanen EI, Baltimore D: Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321, 1995
175. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D: Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376:167, 1995
176. Screpanti I, Romani L, Musiani P, Modesti A, Fattori E, Lazzaro D, Sellitto C, Scarpa S, Bellavia D, Lattanzio G, Bistoni F, Frati L, Cortese R, Gulino A, Ciliberto G, Costantini F, Poli V: Lymphoproliferative disorder and imbalanced T-helper response in C/EBPβ-deficient mice. EMBO J 14:1932, 1995