Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

EMBO Journal

Volumn 20, Issue 4, 2001, Pages 723-733

  Huang, Gang ^a   Shigesada, Katsuya ^a   Ito, Kosei ^a   Wee, Hee Jun ^a   Yokomizo, Tomomasa ^a   Ito, Yoshiaki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

AML 1; PEBP2 ; Proteolytic degradation; Runx1; Ubiquitylation

Indexed keywords

CHIMERIC PROTEIN; TRANSCRIPTION FACTOR; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DNA BINDING PROTEIN; MULTIENZYME COMPLEX; ONCOPROTEIN; PROTEASOME; RUNX1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR RUNX1; UBIQUITIN;

ACUTE GRANULOCYTIC LEUKEMIA; ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; BONE DEVELOPMENT; DIMERIZATION; GENE CONTROL; HEMATOPOIESIS; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; HYDROLYSIS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY;

ANIMALIA; MAMMALIA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DIMERIZATION; DNA-BINDING PROTEINS; HYDROLYSIS; MICE; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; UBIQUITINS;

EID: 0035865459     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.4.723     Document Type: Article

References (38)

1. Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues
2. A simple screening for mutant DNA binding proteins: Application to murine transcription factor PEBP2α subunit, a founding member of the Runt domain protein family
3. The ubiquitin-proteasome pathway: On protein death and cell life
4. Study of osteoblast-specific expression of one mouse osteocalcin gene: Characterization of the factor binding to OSE2
5. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
6. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter
7. The ubiquitin system
8. The runt protein and its companion PEBP2: A close link between this transcription factor and AML
9. Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF
10. The Runt domain identifies a new family of heteromeric transcriptional regulators
11. Functional dissection of the α and β subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity
12. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer
13. Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor α subunit revealed in the presence of the β subunit
14. Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor α (CBFα) subunit by the leukemia-related PEBP2/CBFβ-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation
15. The PEBP2β/CBFβ-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16
16. Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains
17. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
18. Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells
19. Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia
20. Oncogenic transcription factors in the human acute leukemias
21. Subcellular localization of the α and β subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF
22. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
23. Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
24. Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor
25. Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α
26. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
27. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
28. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
29. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
30. CBF α3 (AML2) is induced by TGF-β1 to bind and activate the mouse germline Ig α promoter
31. The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product and potentially regulates its transactivation ability
32. Energetic and functional contribution of residues in the core binding factor β (CBFβ) subunit to heterodimerization with CBFα
33. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
34. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
35. Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFβ
36. Runt domains take the lead in hematopoiesis and osteogenesis
37. A novel transcript encoding an N-terminally truncated AML1/PEBP2αB protein interferes with transactivation and blocks granulocytic differentiation of 32D c13 myeloid cells
38. A RUNX2/PEBP2αA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia