C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts

Blood

Volumn 94, Issue 2, 1999, Pages 560-571

  Wang, Xinping ^b   Scott, Edward ^b   Sawyers, Charles L ^b   Friedman, Alan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; ESTRADIOL; ESTROGEN RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; HYBRID PROTEIN; INTERLEUKIN 3; LACTOFERRIN; MYELOPEROXIDASE; PROTEIN P27; TRANSCRIPTION FACTOR; CCAAT ENHANCER BINDING PROTEIN; DNA BINDING PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTO ONCOGENE PROTEIN SPI 1; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; GENE EXPRESSION; GRANULOPOIESIS; LIGAND BINDING; MOUSE; MYELOBLAST; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; INTERLEUKIN-3; MICE; NEUTROPHILS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0033564978     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.2.560     Document Type: Article

References (59)

1. Britos-Bray M, Friedman AD: Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-myb. Mol Cell Biol 17:5127, 1997
2. Ford AM, Bennett CA, Healy LE, Towatari M, Greaves MF, Enver T: Regulation of the myeloperoxidase enhancer binding proteins PU.1, C/EBPα, β, and δ during granulocyte-lineage specification. Proc Natl Acad Sci USA 93:10838, 1996
3. Hohaus S, Petrovick MS, Voso MT, Sun Z, Zhang D-E, Tenen DG: PU.1 (Spi-1) and CfEBPα regulate expression of the granulocyte-macrophage colony-stimulating factor receptor α gene. Mol Cell Biol 15:5830, 1995
4. Ness SA, Kowenz-Leutz E, Casini T, Graf T, Leutz A: Myb and NF-M: Combinatorial activators of myeloid genes in heterologous cell types. Genes Dev 7:749, 1993
5. Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert S, Friedman AD: PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol Cell Biol 14:5558, 1994
6. Oelgeschläger M, Nuchprayoon I, Lüscher B, Friedman AD: C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol Cell Biol 16:4717, 1996
7. Petrovick MS, Hiebert SW, Friedman AD, Hetherington CJ, Tenen DG, Zhang D-E: Multiple function domains of AML1-PU.1 and C/EBPα synergize with different regions of AML1. Mol Cell Biol 18:3915, 1998
8. Shapiro LH: Myb and Ets proteins cooperate to transactivate an early myeloid gene. J Biol Chem 270:8763, 1995
9. Smith LT, Hohaus S, Gonzalez DA, Dziennis SE, Tenen DG: PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood 88:1234, 1996
10. Suzow J, Friedman AD: The murine myeloperoxidase promoter contains several functional elements - One element binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1). Mol Cell Biol 13:2141, 1993
11. Zhang D-E, Hetherington CJ, Chen H-M, Tenen DG: The macrophage transcription factor PU.1 directs tissue-specific expression of the M-CSF receptor. Mol Cell Biol 14:373, 1994
12. Zhang D-E, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen H-M, Hiebert SW, Tenen DG: CCAAT/enhancer binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol 16;1231, 1996
13. Mucenski ML, McClain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott WJ, Potter SS: A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65:677, 1991
14. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR: AML-1, the target of multiple chromosomal translocations in human leukemia, is essential for normal murine fetal hematopoiesis. Cell 84:321, 1996
15. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA: Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 93:3444, 1996
16. Klemsz MJ, Maki RA: Activation of transcription by PU.1 requires both acidic and glutamine domains. Mol Cell Biol 16:390, 1996
17. Scott EW, Simo MC, Anastasi J, Singh H: Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573, 1994
18. DeKoter RP, Walsh JC, Singh H: PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J 17:4456, 1998
19. McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA: Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities, EMBO J 15:5647, 1996
20. Birkenmeier EH, Gwyenn B, Howard S, Jerry J, Gordon JI, Landschulz WH, McKnight SL: Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/ enhancer binding protein. Genes Dev 3:1146, 1989
21. Chandrasekaran C, Gordon JI: Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein α expression in the gut epithelium of normal and transgenic mice. Proc Natl Acad Sci USA 90:8871, 1993
22. Li F, Rosenberg E, Smith CI, Notarfrancesco K, Reisher SR, Shuman H, Feinstein SI: Correlation of expression of transcription factor C/EBPα and surfactant protein gene in lung cells. Am J Physiol 13:241, 1995
23. Muller C, Kowenz-Leutz E, Grieser-Ada S, Graf T, Leutz A: NF-M (chicken C/EBPβ) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line. EMBO J 14:6127, 1995
24. Nerlov C, McNagny KM, Doderlein G, Kowenz-Leutz E, Graf T: Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. Genes Dev 12:2413, 1998
25. Radomska HS, Huettner CS, Zhang P, Tenen DG: C/EBPα is a regulatory switch sufficient for induction of granulocytic differentiation of bipotential myeloid cells. Mol Cell Biol 18:4301, 1998
26. Scott LM, Civin CI, Rorth P, Friedman AD: A novel temporal pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80:1725, 1992
27. Screpanti I, Romani L, Musiani P, Modesti A, Fattori E, Lazzaro D, Sellitto C, Scarpa S, Bellavia D, Lattanzio G, Bistoni F, Frati L, Cortese R, Gulino A, Ciliberto G, Coslantini F, Poli V: Lymphoproliferative disorder and imbalanced T-helper response in C/EBPβ-deficient mice. EMBO J 14:1932, 1995
28. Tanaka T, Akira S, Yoshida M, Umemoto Y, Yoneda N, Shirafuji H, Suematsu S, Yoshida N, Kishimoto T: Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicitiy by macrophages. Cell 80:353, 1995
29. Zhang D-E, Zhang P, Wang N-D, Hetherington CJ, Darlington GJ, Tenen DG: Absence of G-CSF signaling and neutrophil development in CCAAT enhancer binding protein a-deficient mice. Proc Natl Acad Sci USA 94:569, 1997
30. Lieschke GJ, Grail D, Hodgson G, Metcalf D, Stanley E, Cheers C, Fowler KJ, Basu S, Zhan YF, Dunn AR: Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor deficiency, and impaired neutrophil mobilization. Blood 84:1737, 1994
31. Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC: Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity 5:491, 1996
32. Seymour JF, Lieschke GL, Grail D, Quilici C, Hodgson G, Dunn AR: Mice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival. Blood 90:3037, 1997
33. Friedman AD, Krieder BL, Venturelli D, Rovera G: Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D C13. Blood 78:2426, 1991
34. Valtieri M, Tweardy DJ, Caracciolo D, Johnson K, Mavilio F, Altman S, Snatoli D, Rovera G: Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol 138:3829, 1987
35. Krieder BL, Phillips PD, Prystowksy MB, Shirsat N, Pierce JH, Tushinski R, Rovera G: Induction of the GM-CSF receptor by G-CSF increases the differentiative options of a murine hematopoietic progenitor cell. Mol Cell Biol 10:4846, 1990
36. Dong F, Van Buitenen C, Pouwels K, Hoefsloot LH, Lowenberg B, Touw IP: Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation. Mol Cell Biol 13:7774, 1993
37. Fukunaga R, Ishizaka-Ikeda E, Nagata S: Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell 74:1079, 1993
38. Ziegler SF, Bird TA, Morella KK, Mosley B, Gearing DP, Baumann HZ: Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction. Mol Cell Biol 13:2384, 1993
39. Palacios R, Steinmetz M: IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes. Cell 41:727, 1985
40. Cao W, Britos-Bray M, Claxton DF, Kelley CA, Speck NA, Liu PP, Friedman AD: CBFβ-SMMHC, expressed in M4eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells. Oncogene 15:1315, 1997
41. Danos O, Mulligan RC: Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci USA 85:6460, 1988
42. Pear WS, Nolan GP, Scott ML, Baltimore D: Production of high-titre helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 90:8392, 1993
43. Friedman AD, Landschulz WH, McKnight SL: CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev 3:1314, 1989
44. Umek RM, Friedman AD, McKnight SL: CCAAT-enhancer binding protein: A component of a differentiation switch. Science 251:288, 1991
45. Littlewood TD, Hancock DC, Danielian PS, Parker MG, Evans GI: A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res 23:1686, 1995
46. Morgenstern JP, Land H: Advanced mammalian gene transfer: High titre retroviral receptors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 18:3587, 1990
47. Muller AJ, Young JC, Pendergast A-M, Pondel M, Landau NR, Littman DR, Witte ON: BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol Cell Biol 11:1785, 1991
48. Eisenbaus CF, Singh H, Storb U: Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev 9:1377, 1995
49. de Koning JP, Smith L, Schelen AM, Lowenberg B, Touw IP: STAT3 is essential for down modulation of G-CSF-induced proliferation and neutrophil differentiation. Blood 90:597a, 1997 (abstr, suppl 1)
50. Iwama A, Zhang P, Darlington GJ, McKercher SR, Maki R, Tenen DG: Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPα. Nucleic Acids Res 26:3034, 1998
51. Chen H-M, Ray-Gallet D, Zhang P, Hetherington CJ, Gonzalez DA, Zhang D-E, Moreau-Gachelin F, Tenen DG: PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11:1549, 1995
52. Bellon T, Perrotti D, Calabretta B: Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter. Blood 90:1828, 1998
53. Olson MC, Scott EW, Hack AA, Su GH, Tenen DG, Singh H, Simon MC: PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity 3:703, 1995
54. Nerlov C, Graf T: PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev 12:2403, 1998
55. Behre G, Whitmarsh AJ, Coghlan MP, Hoang T, Carpenter CL, Zhang D-E, Davis RJ, Tenen DG: c-Jun is a JNK-independent coactivator of the PU.1 transcription factor. J Biol Chem 274:4939, 1999
56. Tenen DG, Hromas R, Licht JD, Zhang D-E: Transcription factors, normal myeloid development, and leukemia. Blood 90:489, 1997
57. Ramos RA, Nishio Y, Maiyar AC, Simon KE, Ridder CC, Ge Y, Firestone GL: Glucocorticoid-stimulated CCAAT/enhancer binding protein a expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells. Mol Cell Biol 16:5288, 1996
58. Timchencko NA, Wilde M, Nakanishi M, Smith JR, Darlington GJ: C/EBPα inhibits cell proliferation through the p21 protein. Genes Dev 10:804, 1996
59. Shimozaki K, Nakajima K, Hirano T, Nagata S: Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells. J Biol Chem 272:25184, 1997