CCAAT/enhancer binding protein ε is a potential retinoid target gene in acute promyelocytic leukemia treatment

Journal of Clinical Investigation

Volumn 103, Issue 10, 1999, Pages 1399-1408

  Park, Dorothy J ^a   Chumakov, Alexey M ^a   Vuong, Peter T ^a   Chih, Doris Y ^a   Gombart, Adrian F ^a   Miller Jr , Wilson H ^b   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; NUCLEAR FACTOR; RETINOID;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032694990     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2887     Document Type: Article

References (55)

1. Evans, R.M. 1988. The steroid and thyroid hormone receptor super family. Science. 240:889-895.
2. Leid, M., et al. 1992. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell. 68:377-395.
3. 3 signalling. Nature. 355:446-449.
4. Huang, M.E., et al. 1988. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood. 72:567-572.
5. Warrell, R.P., Jr., et al. 1991. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N. Engl. J. Med. 324:1385-1393.
6. Heyman, R.A., et al. 1992. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell. 68:397-406.
7. Levin, A.A., et al. 1992. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. Nature. 355:359-361.
8. de The, H., Chomienne, C., Lanotte, M., Degos, L., and Dejean, A. 1990. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor a gene to a novel transcribed locus. Nature. 347:558-561.
9. 3 receptors. Cell. 65:1255-1266.
10. Goddard, A.D., Borrow, J., Freemont, P.S., and Solomon, E. 1991. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science. 254:1371-1374.
11. Kastner, P., et al. 1992. Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J. 11:629-642.
12. Perez, A., et al. 1993. PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR. EMBO J. 12:3171-3182.
13. Birkenmeier, E.H., et al. 1989. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev. 3:1146-1156.
14. Scott, L.M., Civin, C.I., Rorth, P., and Friedman, A.D. 1992. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood. 80:1725-1735.
15. Zhang, D.E., et al. 1997. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CC AAT enhancer binding protein alpha-deficient mice. Proc. Natl. Acad. Sci. USA. 94:569-574.
16. Hohaus, S., et al. 1995. PU.1 (Spi-1) and C/EBP a regulate expression of the granulocyte-macrophage colony-stimulating factor receptor α gene. Mol. Cell. Biol. 15:5830-5845.
17. Ness, S.A., Kowenz-Leutz, E., Casini, T., Graf, T., and Leutz, A. 1993. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 7:749-759.
18. Oelgeschlager, M., Nuchprayoon, I., Luscher, B., and Friedman, A.D. 1996. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. AM Cell. Biol. 16:4717-4725.
19. Smith, L.T., Hohaus, S., Gonzalez, D.A., Dziennis, S.E., and Tenen, D.G. 1996. PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood. 88:1234-1247.
20. Zhang, D.E., et al. 1996. Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters. Curr. Top. Microbiol. Immunol. 211:137-147.
21. Antonson, P., Stellan, B., Yamanaka, R., and Xanthopoulos, K.G. 1996. A novel human CCAAT/enhancer binding protein gene, C/EBPε, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor α/δ locus. Genomics. 35:30-38.
22. Chih, D., Chumakov, A.M., Park, D.J., Silla, A.G., and Koeffler, H.P. 1997. Modulation of mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBPε). Blood. 90:2987-2994.
23. Chumakov, A.M., et al. 1997. Cloning of the novel human myeloid-cell-specific C/EBPε transcription factor. Mol. Cell. Biol. 17:1375-1386.
24. Morosetti, R., et al. 1997. A novel, myeloid transcription factor, C/EBPε, is upregulated during granulocytic, bur nor monocytic, differentiation. Blood. 90:2591-2600.
25. Yamanaka, R., et al. 1997. CCAAT/enhancer binding protein E is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc. Natl. Acad. Sci. USA. 94:6462-6467.
26. Yamanaka, R., et al. 1998. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ε-deficient mice. Proc. Natl. Acad. Sci. USA. 94:13187-13192.
27. Lanotte, M., et al. 1991. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood. 77:1080-1086.
28. Kizaki, M., et al. 1996. Establishment and characterization of a novel acute promyelocytic leukemia cell line (UF-1) with retinoic acid-resistant features. Blood. 88:1824-1833.
29. Grignani, F., et al. 1993. The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell. 74:423-431.
30. Ruthardt, M., et al. 1997. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor α (RARα) and PLZF-RARα fusion proteins on retinoic acid signalling. Mol. Cell. Biol. 17:4859-4869.
31. Rosenauer, A., et al. 1996. Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wild-type retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines. Blood. 88:2671-2682.
32. Koeffler, H.P. and Golde, D.W. 1978. Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity. Science. 200:1153-1154.
33. Luckow, B. and Schutz, G. 1987. CAT constructions with multiple unique restriction sices for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 1:5490.
34. Ke, S.H., and Madison, EL. 1997. Rapid and efficient site-directed mutagenesis by single-tube 'megaprimer' PCR method. Nucleic Acids Res. 25:3371-3372.
35. Kakizuka, A., et al. 1991. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell. 66:663-674.
36. Kurokawa, R., et al. 1995. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature. 377:451-454.
37. Cook, D.M., Hinkes, M.T., Bernfield, M., and Rauscher, F.J. 1996. Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1. Oncogene. 13:1789-1799.
38. Park, D.J., et al. 1994. Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines. Oncogene. 9:1899-1906.
39. de The, H., Marchio, A., Tiollais, P., and Dejean, A. 1989. Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes. EMBO J. 8:429-433.
40. Pandolfi, P.P., et al. 1992. Genomic variability and alternative splicing generate multiple PML/RARα transcripts that encode aberrant PML proteins and PML/RARα isoforms in acute promyelocytic leukaemia. EMBO J. 11:1397-1407.
41. Guidez, F., et al. 1994. Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RARα patient. Leukemia. 8:312-317.
42. Shao, W., Benedetti, L., Lamph, W.W., Nervi, C., and Miller, W.H., Jr. 1997. A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RARα mutation. Blood. 89:4282-4289.
43. Shivdasani, R.A, and Orkin, S.H. 1996. The transcriptional control of hematopoiesis. Blood. 87:4025-4039.
44. Tenen, D.G., Hromas, R., Licht, J.D., and Zhang, D.E. 1997. Transcription factors, normal myeloid development, and leukemia. Blood. 90:489-519.
45. Chen, A., et al. 1994. Recinoic acid is required for and potentiates differentiation of acute promyelocytic leukemia cells by nonretinoid agents. Blood. 84:2122-2129.
46. 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RARα/PML proteins. Blood. 88:1032-1061.
47. 3. Cancer Res. 54:4508-4515.
48. Licht, J.D., et al. 1995. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood. 85:1083-1094.
49. Hong, S.H., David, G., Wong, C.W., Dejean, A., and Privalsky, M.L. 1997. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA. 94:9028-9033.
50. Khanna-Gupta, A., Kolibaba, K., Zibello, T.A., and Berliner, N. 1994. NB4 cells show bilineage potential an dan aberrant pattern of neutrophil secondary granule protein gene expression. Blood. 84:294-302.
51. Khanna-Gupta, A., Zibello, T., and Berliner, N. 1996. Coordinate regulation of neutrophil secondary granule protein gene expression. Curr. Top. Microbiol. Immunol. 211:165-171.
52. Drach, J., Zhao, S., Malavasi, F., and Mehta, K. 1993. Rapid induction of CD38 antigen on myeloid leukemia cells by all trans-retinoic acid. Biochem. Biophys. Res. Commun. 195:545-550.
53. Fraij, B.M., Birckbichler, P.J., Patterson, M.K.J., Lee, K.N., and Gonzales, R.A. 1992. A retinoic acid-inducible mRNA from human erythroleukemia cells encodes a novel tissue transglutaminase homologue. J. Biol. Chem. 267:22616-22623.
54. Gianni, M., et al. 1997. Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells. Blood. 89:1001-1012.
55. Scott, L.M., Mueller, L., and Collins, S.J. 1996. E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor a Blood. 88:2517-2530.