C/EBP∈ -/- mice: Increased rate of myeloid proliferation and apoptosis

Leukemia

Volumn 15, Issue 1, 2001, Pages 103-111

  Verbeek, W ^a   Waachter M ^a   Lekstrom Himes, J ^a   Koeffler, H P ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Apoptosis; CCAAT enhancer binding protein epsilon; Myeloid proliferation

Indexed keywords

BROXURIDINE; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN EPSILON; CELL ANTIGEN; CYTOKINE; ETOPOSIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CEBPE PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL LABELING; CELL MATURATION; CELL PROLIFERATION; COLONY FORMATION; COLONY FORMING UNIT GM; CONTROLLED STUDY; FEMUR; GENE DISRUPTION; GRANULOCYTE; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; KNOCKOUT MOUSE; MONONUCLEAR CELL; MOUSE; MOUSE STRAIN; MYELOPOIESIS; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; ANIMAL; GENE DELETION; GENETICS; HOMOZYGOTE; LEUKOPOIESIS;

ANIMALS; APOPTOSIS; CCAAT-ENHANCER-BINDING PROTEINS; GENE DELETION; HOMOZYGOTE; LEUKOPOIESIS; MICE;

EID: 0034746508     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401995     Document Type: Article

References (34)

1. Impaired granulopoiesis, myelodysplasia and early lethality in CCAAT/enhancer binding protein ε-deficient mice
2. Cloning of the novel human myeloid-cell-specific C/EBPε transcription factor
3. A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic differentiation
4. A novel human CCAAT/enhancer binding protein gene, C/EBPε is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor α/δ locus
5. Modulation of mRNA expression of a novel human myeloid selective CCAAT/enhancer binding protein gene (C/EBP epsilon)
6. CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge
7. C/EBPε directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters
8. Myeloid transcription factor C/EBPε is involved in the positive regulation of lactoferrin gene expression in neutrophils
9. CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice
10. CCAAT/enhancer-binding protein alpha(C/EBPα) inhibits proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein
11. Granulocyte colony stimulating factor regulates myeloid differentiation through CCAAT enhancer binding protein epsilon
12. Identification of lactoferrin as the granulocyte-derived inhibitor of colony stimulating activity production
13. Suppression of mouse myelopoiesis by administration of human lactoferrin in vivo and the comparative action of human transferrin
14. Serum granulocyte colony stimulating factor in patients with repeated infections
15. Effect of endotoxin on serum granulocyte and granulocyte-macrophage colony stimulating factor levels in dogs
16. Recombinant human TNF induces production of granulocyte-monocyte colony stimulating factor
17. Recombinant human TNFα stimulates the secretion of granulocyte colony-stimulating factor in vivo
18. Granulocyte colony colony-stimulating factor and granulocyte-macrophage colony stimulating factor
19. Evidence for a novel in vivo control mechanism of granulopoiesis: Mature cell-related control of a regulatory growth factor
20. Close association between clearance of recombinant human granulocyte colony stimulating factor (G-CSF) and G-CSF receptor on neutrophils in cancer patients
21. The opposing actions on murine myelopoiesis of purified preparations of lactoferrin and the colony stimulating factors
22. Monoclonal antibody II2c to human lactoferrin inactivates the myelopoiesis suppressive effect of human lactoferrin in vitro
23. The effects in vivo of purified preparations of murine macrophage colony stimulating factor-1, recombinant granulocyte-macrophage colony stimulating factor and natural and recombinant murine interleukin 3 of mice with iron saturated human lactoferrin
24. Lactoferrin: Affinity purification from human milk and polymorphonuclear neutrophils using monoclonal antibody (II2C) to human lactoferrin, development of an immunoradiometric assay using II2C and myelopoietic binding characteristics
25. Lactoferrin acts on Ia and IE/C antigen + subpopulations of mouse peritoneal macrophages in the absence of T-lymphocytes and other cell types to inhibit production of granulocyte-macrophage colony stimulating factors in vitro
26. Lactoferrin decreases monocyte-induced fibroblast production of myeloid colony stimulating activity by suppressing monocyte release of interleukin 1
27. Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities
28. Effects of CC, CXC, C and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF1 induced chemotaxis of progenitors
29. Myelosuppressive effects of purified recombinant murine MIP 1 alpha
30. A novel chemokine, macrophage inflammatory related protein 2 inhibits colony formation of bone marrow myeloid progenitors
31. Involvement of interleukin (IL)-8 receptor in negative regulation of myeloid progenitor cells in vivo: Evidence from mice lacking the murine IL-8 receptor homologue
32. Dominant myelopoietic effector functions mediated by chemokine receptor CCR1
33. Enhanced myeloid progenitor cell cycling in mice lacking the chemokine receptor CCR2
34. C/EBPε is a myeloid-specific activator of cytokine, chemokine, and macrophage colony-stimulating factor receptor genes