Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein α in myelodysplastic syndromes and acute myeloid leukemias

Blood

Volumn 99, Issue 4, 2002, Pages 1332-1340

  Gombart, Adrian F ^a,b,c   Hofmann, Wolf K ^a,b,c   Kawano, Seiji ^a,b,c   Takeuchi, Seisho ^a,b,c   Krug, Utz ^a,b,c   Kwok, Scott H ^a,b,c   Larsen, Renee J ^a,b,c   Asou, Hiroya ^a,b,c   Miller, Carl W ^a,b,c   Hoelzer, Dieter ^a,b,c   Phillip Koeffler, H ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CELL DNA; LEUCINE ZIPPER PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADIPOSE TISSUE; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; DNA DETERMINATION; GENE DELETION; GENE FUNCTION; GENE INSERTION; GENE LOCATION; GENE MUTATION; GENETIC CODE; GENETIC POLYMORPHISM; GRANULOCYTE; HUMAN; HUMAN TISSUE; LIVER FUNCTION; LUNG FUNCTION; LUNG NON SMALL CELL CANCER; MYELODYSPLASTIC SYNDROME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; SILENT GENE; STOP CODON; TISSUE DIFFERENTIATION;

EID: 0037082508     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.4.1332     Document Type: Article

References (56)

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3. Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter
4. CRP2 (C/EBP beta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity
5. Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein epsilon
6. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells
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12. Expression and hormonal regulation of the CCAAT enhancer binding protein-alpha during differentiation of rat ovarian follicles
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14. Mouse insulin-responsive glucose transporter gene: Characterization of the gene and trans-activation by the CCAAT/enhancer binding protein
15. The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenol-pyruvate carboxykinase (GTP)
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17. PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene
18. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
19. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
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26. Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen
27. CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
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29. CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice
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31. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha
32. Hepatocytes deficient in CCAAT/enhancer binding protein alpha (C/EBP alpha) exhibit both hepatocyte and biliary epithelial cell character
33. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis
34. Expression of the liver-enriched transcription factors C/EBP alpha, C/EBP beta, HNF-1, and HNF-4 in preneoplastic nodules and hepatocellular carcinoma in rat liver
35. Lack of C/EBP alpha gene expression results in increased DNA synthesis and an increased frequency of immortalization of freshly isolated mice [correction of rat] hepatocytes
36. Expression of CCAAT/enhancer binding proteins (C/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in skin neoplasms
37. Human papillomaviruses and cervical cancer: Analysis of histopathologic features associated with different viral types
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45. Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP
46. The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding
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48. c-Myc is a critical target for c/EBPalpha in granulopoiesis
49. C/EBPalpha inhibits cell growth via direct repression of E2F-DP-mediated transcription
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