C/EBPα arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

Molecular Cell

Volumn 8, Issue 4, 2001, Pages 817-828

  Wang, Hongmei ^a   Iakova, Polina ^a   Wilde, Margie ^a   Welm, Alana ^a   Goode, Triona ^a   Roesler, William J ^b   Timchenko, Nikolai A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CCAAT ENHANCER BINDING PROTEIN ALPHA; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLINE; CDK2 PROTEIN, MOUSE; CDK2 PROTEIN, RAT; CDK4 PROTEIN, MOUSE; CDK4 PROTEIN, RAT; CYCLIN DEPENDENT KINASE; ENZYME INHIBITOR; HYBRID PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIVER; MITOSIS INHIBITION; MOLECULAR WEIGHT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; AMINO ACID SEQUENCE; ANIMAL; CELL DIVISION; CELL FRACTIONATION; CHEMISTRY; DRUG ANTAGONISM; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; MOUSE MUTANT; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; REPORTER GENE;

ANIMALIA; STAPHYLOCOCCUS PHAGE 187;

AMINO ACID SEQUENCE; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CDC2-CDC28 KINASES; CELL DIVISION; CELL FRACTIONATION; CELL LINE; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; GENES, REPORTER; LIVER; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; RECOMBINANT FUSION PROTEINS;

EID: 0034740215     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00366-5     Document Type: Article

References (23)

1. Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes
2. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
3. Identification of CDK4 Sequences Involved in Cyclin D1 and p16 Binding
4. Role of the CCAAT/enhancer binding protein-alpha transcription factor in the glucocorticoid stimulation of p21waf1/cip1 gene promoter activity in growth-arrested rat hepatoma cells
5. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
6. Adenovirus-mediated transfer of CCAAT/Enhancer binding protein alpha identifies a dominant antiproliferative role for this isoform in hepatocytes
7. The regulation of E2F by RB-family proteins
8. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/Enhancer binding protein
9. CCAAT/enhancer binding protein alpha cooperates with p21 to inhibit cyclin-dependent kinase 2 activity and induces growth arrest independent of DNA binding
10. Inhibition of cyclin dependent kinases by p21
11. Inhibition of cell proliferation by C/EBP occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen
12. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
13. Separation of C/EBPα-mediated proliferation arrest and differentiation pathways
14. Characterization of CCAAT/enhancer-binding protein alpha as a cyclic AMP-responsive nuclear regulator
15. CDK inhibitors: Positive and negative regulators of G1-phase progression
16. CCAAT/enhancer-binding protein (C/EBP) inhibits cell proliferation through the p21 (WAF-/CIP-1/SDI-1) protein
17. CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice
18. C/EBP alpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice
19. E2F/p107 and E2F/P130 complexes are regulated by C/EBP in 3T3-L1 adipocytes
20. Impaired energy homeostasis in C/EBP alpha knockout mice
21. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins
22. CCAAT-Enhancer Binding Protein: A component of a differentiation switch
23. Direct inhibition of G1 cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation