C/EBP-β, C/EBP-δ, PU.1, AML1 genes: Mutational analysis in 381 samples of hematopoietic and solid malignancies

Leukemia Research

Volumn 26, Issue 5, 2002, Pages 451-457

  Vegesna, Vijaya ^a   Takeuchi, Seisho ^b   Hofmann, Wolf K ^a   Ikezoe, Takayuki ^a   Tavor, Sigal ^a   Krug, Utz ^a   Fermin, Anthony C ^a   Heaney, Anthony ^a   Miller, Carl W ^a   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

AML1; C EBP ; C EBP ; Cancer; Mutations; PU.1

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; GENOMIC DNA; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ARTICLE; BURKITT LYMPHOMA; CANCER CELL CULTURE; CHRONIC MYELOID LEUKEMIA; CODON; CONTROLLED STUDY; DNA SEQUENCE; EXON; GENE MUTATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PATHOGENESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SILENT GENE; SINGLE STRAND CONFORMATION POLYMORPHISM; SOLID TUMOR;

CCAAT-ENHANCER-BINDING PROTEIN-BETA; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CCAAT-ENHANCER-BINDING PROTEINS; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DNA-BINDING PROTEINS; HEMATOLOGIC NEOPLASMS; HUMANS; MUTATION; NEOPLASMS; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 18344372734     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(01)00150-3     Document Type: Article

References (30)

1. The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia
2. The critical role of chromosome translocations in human leukemias
3. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MT8 fusion transcript
4. The AML/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B
5. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
6. Mutations of the AML1 gene in Myelodysplastic syndrome and their functional implications in leukemogenesis
7. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia
8. Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia
9. Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival
10. Analysis of RAS genes mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes
11. Function of PU.1 (Spi-1), C/EBP and AML1 in early myelopoiesis: Regulation of multiple myeloid CSF receptor promoters
12. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha 2) synergistically activate the macrophage colony-stimulating factor receptor promoter
13. Multiple functional domains of AML1, PU.1 and C/EBP alpha synergize with different regions of AML1
14. Macrophage transcription factor PU.1 directs tissue specific expression of the macrophage colony stimulating receptor
15. The human homologue of the putative proto-oncogene Spi-1 characterization and expression in tumors
16. Role of the PU.1 transcription factor in controlling differentiation of Friend erythroleukemia cells
17. Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
18. Myeloid transcription factor C/EBP-ε is involved in the positive regulation of lactoferrin gene expression in neutrophils
19. CCAAT/enhancer-binding protein delta gene expression is mediated by autoregulation through downstream binding sites
20. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
21. Dominant-negative mutations of CEBP-α, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
22. Mutations in the gene encoding the transcription factor C/EBP-α in myelodysplastic syndromes and acute myeloid leukemias
23. The CCAAT/enhancer binding protein and its role in adipocyte differentiation: Evidence for direct involvement in terminal adipocyte development
24. Local signals induce CCAAT/enhancer binding protein-delta (C/EBP-δ) and C/EBP-beta mRNA expression in the involuting mouse mammary gland
25. The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: Specific increase in C/EBPβ during epithelial tumor progression
26. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells
27. P53 mutations in HPV-negative cervical carcinoma
28. Loss of alleles at loci on human chromosome 11 during genesis of Wilm's tumor
29. Loss of genes on the short arm of chromosome 11 in bladder cancer
30. The osteocalcin gene promoter provides a molecular blueprint for regulatory mechanisms controlling bone tissue formation: Role of transcription factors involved in development