Induction of granulocytic differentiation by 2 pathways

Blood

Volumn 99, Issue 12, 2002, Pages 4406-4412

  Zhang, Pu ^a,b,c   Nelson, Erik ^a,b,c   Radomska, Hanna S ^a,b,c   Iwasaki Arai, Junko ^a,b,c   Akashi, Koichi ^a,b,c   Friedman, Alan D ^a,b,c   Jenen, Daniel G ^a,b,c,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CYTOKINE; INTERLEUKIN 3; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; GENE INDUCTION; GENOTYPE; GRANULOCYTE; GRANULOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0037097736     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.12.4406     Document Type: Article

References (44)

1. Transcription factors, normal myeloid development, and leukemia
2. Diversification of haematopoietic stem cells to specific lineages
3. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells
4. CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
5. PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
6. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
7. C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
8. Dominant negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
9. AML1-ETO downregulates the granulocylic differentiation factor C/EBPβ in t(8;21) myeloid leukemia
10. Early retinoid induction of C/EBPβ binding activity is associated with APL cell differentiation
11. C/EBP β is an important target of PML/RARA during ATRA induced differentiation of APL cells
12. CCAAT/enhancer binding protein ε is a potential retinoid target gene in acute promyelocytic leukemia treatment
13. Impaired energy homeostasis in C/EBPα knockout mice
14. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
15. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein α (C/EBPα) is critical for granulopoiesis
16. Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPα
17. The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors
18. Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line
19. CCAAT-enhancer binding protein: A component of a differentiation switch
20. Isolation of biologically active ribonucleic acid from sources rich in ribonuclease
21. Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis
22. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
23. PU.1 regulates both cytokine dependent proliferation and differentiation of granulocyte/macrophage progenitors
24. PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation
25. Overexpression of Hox11 leads to the immortalization of embryonic precursors with both primitive and definitive hematopoietic potential
26. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
27. The purification and characterization of fetal liver hematopoietic stem cells
28. Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment
29. Distinct mouse bone marrow macrophage precursors identified by differential expression of ER-MP12 and ER-MP20 antigens
30. High-level expression of the ER-MP58 antigen on mouse bone marrow hematopoietic progenitor cells marks commitment to the myeloid lineage
31. Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1
32. Impaired generation of bone marrow B lymphocytes in mice deficient in C/EBP β
33. The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression
34. Establishment and characterization of a human histiocytic lymphoma cell line (U-937)
35. Differentiation of K562 leukemia cells along erythroid, macrophage, and megakaryocyte lineages
36. C/EBPs are required for granulopoiesis independent of their induction of the granulocyte-colony stimulating factor receptor
37. C/EBP ε mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP/cut)
38. Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene
39. CCAAT/enhancer binding protein-α amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells
40. Overexpression of wild-type retinoic acid receptor α (RARα) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARα-fusion genes
41. Interleukin-6 and the granulocyte colony stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation
42. Positive and negative regulation of granulopoiesis by endogenous RARα
43. C/EBPα deficiency blocks granulocytic differentiation at the common myeloid progenitor stage in both adult and fetal liver myelopoiesis
44. Reciprocal roles for CCAAT/Enhancer Binding Protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment