AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis

Blood Cells, Molecules, and Diseases

Volumn 27, Issue 2, 2001, Pages 368-376

  Zhang, Dong Er ^a   Burel, Sebastien ^a   Zhou, Liming ^a   Hetherington, Christopher J ^a   Yuan, Youzhong ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN;

ARTICLE; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; LEUKEMIA; LEUKEMOGENESIS; PRIORITY JOURNAL;

EID: 0034970803     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2001.0391     Document Type: Article

References (44)

1. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
2. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
3. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
4. Colony-stimulating factor-1 receptor
5. Transcriptional regulation in myeloid cell differentiation
6. Transcription factors, normal myeloid development, and leukemia
7. The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor
8. Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)
9. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
10. Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1
11. The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B
12. AML1A and AML1B can transactivate the human IL-3 promoter
13. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
14. Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-Myb
15. The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation
16. Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions
17. Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors
18. Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by Cbf and ets requires intact binding sites for both proteins
19. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
20. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
21. Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials
22. Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis
23. Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta
24. AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein
25. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene
26. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
27. Expression of a knocked-In AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors
28. A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation
29. Ubiquitin-dependent protein degradation
30. Deubiquitinating enzymes: A new class of biological regulators
31. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model
32. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
33. Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis
34. Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle
35. Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - A model for overcoming inhibition of proliferation by CBF oncoproteins
36. The t(8;21) translocation is not consistently associated with high Bcl- 2 expression in de novo acute myeloid leukemias of adults
37. Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality
38. The AML1/ETO fusion protein activates transcription of BCL-2
39. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
40. CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
41. Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding
42. High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors