Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a Gi Protein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells

Journal of Biological Chemistry

Volumn 276, Issue 22, 2001, Pages 19672-19677

  Morales Ruiz, Manuel ^a   Lee, Menq Jer ^c   Zöllner, Stefan ^a   Gratton, Jean Philippe ^a   Scotland, Ramona ^a   Shiojima, Ichiro ^b   Walsh, Kenneth ^b   Hla, Timothy ^c   Sessa, William C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST ELIZABETH'S MEDICAL CENTER   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; GENES; NITROGEN OXIDES;

ENDOTHELIAL CELLS; PHOSPHORYLATION;

BIOCHEMISTRY;

ENDOTHELIAL DIFFERENTIATION GENE RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GENE PRODUCT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG; VASCULOTROPIN; BORDETELLA VIRULENCE FACTOR; CELL SURFACE RECEPTOR; DRUG DERIVATIVE; ENDOTHELIAL CELL GROWTH FACTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LYMPHOKINE; LYSOPHOSPHOLIPID; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; VASCULOTROPIN A;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL GROWTH; CELL MIGRATION; CELL SURVIVAL; CHEMOTAXIS; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INHIBITION KINETICS; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANGIOGENESIS; ANIMAL; BIOSYNTHESIS; CATTLE; CELL MOTION; CYTOLOGY; DOMINANT GENE; DOSE RESPONSE; ENZYMOLOGY; GENETICS; LUNG; METABOLISM; NORTHERN BLOTTING; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; TIME; VASCULAR ENDOTHELIUM;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CATTLE; CELL MOVEMENT; CHEMOTAXIS; CULTURE MEDIA, SERUM-FREE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GENES, DOMINANT; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; LUNG; LYMPHOKINES; LYSOPHOSPHOLIPIDS; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SPHINGOSINE; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VIRULENCE FACTORS, BORDETELLA;

EID: 0035374461     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009993200     Document Type: Article

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