메뉴 건너뛰기




Volumn 65, Issue 1, 1999, Pages 7-12

Function and dysfunction of the presenilins

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

EID: 0033362096     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302475     Document Type: Article
Times cited : (57)

References (44)
  • 1
    • 0031108103 scopus 로고    scopus 로고
    • Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signaling independently of proteolytic processing
    • Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grünberg J, Haass C (1997) Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signaling independently of proteolytic processing. Genes Funct 1:149-159
    • (1997) Genes Funct , vol.1 , pp. 149-159
    • Baumeister, R.1    Leimer, U.2    Zweckbronner, I.3    Jakubek, C.4    Grünberg, J.5    Haass, C.6
  • 2
    • 0030833055 scopus 로고    scopus 로고
    • Accelerated amyloid deposition in the brains of transgenic mice co-expressing mutant presenilin 1 and amyloid precursor proteins
    • Borchelt DR, Ratovitski T, Van Lare J, Lee MK, Gonzales VB, Jenkins NA, Copeland NG, et al (1997) Accelerated amyloid deposition in the brains of transgenic mice co-expressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-945
    • (1997) Neuron , vol.19 , pp. 939-945
    • Borchelt, D.R.1    Ratovitski, T.2    Van Lare, J.3    Lee, M.K.4    Gonzales, V.B.5    Jenkins, N.A.6    Copeland, N.G.7
  • 3
  • 6
    • 0033362157 scopus 로고    scopus 로고
    • Microglia and the immune pathology of Alzheimer disease
    • in this issue
    • Giulian D (1999) Microglia and the immune pathology of Alzheimer disease. Am J Hum Genet 65:13-18 (in this issue)
    • (1999) Am J Hum Genet , vol.65 , pp. 13-18
    • Giulian, D.1
  • 7
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, et al (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4: 97-100
    • (1998) Nat Med , vol.4 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3    Yu, X.4    Benkovic, S.5    Jantzen, P.6    Wright, K.7
  • 8
    • 0030890399 scopus 로고    scopus 로고
    • Endoproteolytic cleavage and proteosomal degradation of presenilin 2 in transfected cells
    • Kim T-W, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE (1997) Endoproteolytic cleavage and proteosomal degradation of presenilin 2 in transfected cells. J Biol Chem 272:11006-11010
    • (1997) J Biol Chem , vol.272 , pp. 11006-11010
    • Kim, T.-W.1    Pettingell, W.H.2    Hallmark, O.G.3    Moir, R.D.4    Wasco, W.5    Tanzi, R.E.6
  • 11
    • 16044365171 scopus 로고    scopus 로고
    • The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
    • Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, et al (1996) The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nat Med 2:1146-1150
    • (1996) Nat Med , vol.2 , pp. 1146-1150
    • Lemere, C.A.1    Lopera, F.2    Kosik, K.S.3    Lendon, C.L.4    Ossa, J.5    Saido, T.C.6    Yamaguchi, H.7
  • 13
    • 0029116848 scopus 로고
    • Facilitation of lin-12-mediated signaling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    • Levitan D, Greenwald I (1995) Facilitation of lin-12-mediated signaling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377:351-354
    • (1995) Nature , vol.377 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 14
    • 0031753831 scopus 로고    scopus 로고
    • Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans
    • -(1998) Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Development 125:3599-3606
    • (1998) Development , vol.125 , pp. 3599-3606
  • 17
    • 0030293894 scopus 로고    scopus 로고
    • Membrane topology of the C. elegans SEL-12 presenilin
    • Li X, Greenwald I (1996) Membrane topology of the C. elegans SEL-12 presenilin. Neuron 17:1015-1021
    • (1996) Neuron , vol.17 , pp. 1015-1021
    • Li, X.1    Greenwald, I.2
  • 18
    • 0030671560 scopus 로고    scopus 로고
    • HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
    • -(1997) HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc Natl Acad Sci USA 94:12204-12209
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12204-12209
  • 20
    • 0032905727 scopus 로고    scopus 로고
    • Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex
    • Nishimura M, Yu G, Levesque G, Zhang DM, Ruel L, Chen F, Milman P, et al (1999) Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex. Nat Med 5:164-169
    • (1999) Nat Med , vol.5 , pp. 164-169
    • Nishimura, M.1    Yu, G.2    Levesque, G.3    Zhang, D.M.4    Ruel, L.5    Chen, F.6    Milman, P.7
  • 22
    • 0031921466 scopus 로고    scopus 로고
    • Mutant genes in familial Alzheimer's disease and transgenic models
    • Price DL, Sisodia SS (1998) Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci 21:479-505
    • (1998) Annu Rev Neurosci , vol.21 , pp. 479-505
    • Price, D.L.1    Sisodia, S.S.2
  • 24
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, et al (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376: 775-778
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3    Levesque, G.4    Ikeda, M.5    Liang, Y.6    Chi, H.7
  • 25
    • 0033553564 scopus 로고    scopus 로고
    • Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing
    • Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G (1999) Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing. J Biol Chem 274:13818-13823
    • (1999) J Biol Chem , vol.274 , pp. 13818-13823
    • Saura, C.A.1    Tomita, T.2    Davenport, F.3    Harris, C.L.4    Iwatsubo, T.5    Thinakaran, G.6
  • 27
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, et al (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2:864-870
    • (1996) Nat Med , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6    Bird, T.D.7
  • 28
    • 0032211830 scopus 로고    scopus 로고
    • The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
    • Selkoe DJ (1998) The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol 8:447-453
    • (1998) Trends Cell Biol , vol.8 , pp. 447-453
    • Selkoe, D.J.1
  • 30
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, et al (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3    Rogaeva, E.A.4    Levesque, G.5    Ikeda, M.6    Chi, H.7
  • 31
    • 0033515530 scopus 로고    scopus 로고
    • Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071
    • Stahl B, Diehlmann A, Sudhoff TC (1999) Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. J Biol Chem 274:9141-9148
    • (1999) J Biol Chem , vol.274 , pp. 9141-9148
    • Stahl, B.1    Diehlmann, A.2    Sudhoff, T.C.3
  • 32
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • Struhl G, Greenwald I (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398: 522-525
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 36
    • 0031054505 scopus 로고    scopus 로고
    • Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein
    • Weidemann A, Paliga K, Dürrwang U, Czech C, Evin G, Masters CL, Beyreuther K (1997) Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and β-amyloid precursor protein. Nat Med 3:328-332
    • (1997) Nat Med , vol.3 , pp. 328-332
    • Weidemann, A.1    Paliga, K.2    Dürrwang, U.3    Czech, C.4    Evin, G.5    Masters, C.L.6    Beyreuther, K.7
  • 37
    • 0033514950 scopus 로고    scopus 로고
    • Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling
    • Westlund B, Parry D, Clover R, Basson M, Johnson CD (1999) Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. Proc Natl Acad Sci USA 96: 2497-2502
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2497-2502
    • Westlund, B.1    Parry, D.2    Clover, R.3    Basson, M.4    Johnson, C.D.5
  • 38
    • 0033535553 scopus 로고    scopus 로고
    • Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
    • Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398:513-517
    • (1999) Nature , vol.398 , pp. 513-517
    • Wolfe, M.S.1    Xia, W.2    Ostaszewski, B.L.3    Diehl, T.S.4    Kimberly, W.T.5    Selkoe, D.J.6
  • 40
    • 0030753089 scopus 로고    scopus 로고
    • Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
    • Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ (1997) Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proc Natl Acad Sci USA 94:8208-8213
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8208-8213
    • Xia, W.1    Zhang, J.2    Perez, R.3    Koo, E.H.4    Selkoe, D.J.5
  • 41
    • 0033535555 scopus 로고    scopus 로고
    • Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants
    • Ye Y, Lukinova N, Fortini ME (1999) Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants. Nature 398:525-529
    • (1999) Nature , vol.398 , pp. 525-529
    • Ye, Y.1    Lukinova, N.2    Fortini, M.E.3
  • 42
    • 0032568821 scopus 로고    scopus 로고
    • The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
    • Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva E, et al (1998) The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem 273: 16470-16475
    • (1998) J Biol Chem , vol.273 , pp. 16470-16475
    • Yu, G.1    Chen, F.2    Levesque, G.3    Nishimura, M.4    Zhang, D.M.5    Levesque, L.6    Rogaeva, E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.