Mechanism of Inhibition of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE) by a Statine-based Peptide

Journal of Biological Chemistry

Volumn 276, Issue 26, 2001, Pages 23790-23794

  Marcinkeviciene, Jovita ^a   Luo, Ying ^a   Graciani, Nilsa R ^a   Combs, Andrew P ^a   Copeland, Robert A ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; FREE ENERGY; OPTIMIZATION; PROTEINS;

INHIBITOR BINDING RATES;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; ENZYME INHIBITOR; AMINO ACID; BACE1 PROTEIN, HUMAN; BACE2 PROTEIN, HUMAN; BETA SITE APP CLEAVING ENZYME 2; BETA-SITE APP CLEAVING ENZYME 2; PEPTIDE; PROTEINASE; SECRETASE; STATINE;

ALZHEIMER DISEASE; ARTICLE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; HUMAN; LIGAND BINDING; NEUROLOGIC DISEASE; PRIORITY JOURNAL; STEADY STATE; CHEMISTRY; DRUG ANTAGONISM; KINETICS; METABOLISM; PROTEIN CONFORMATION;

AMINO ACIDS; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; FLUORESCENCE; HUMANS; KINETICS; PEPTIDES; PROTEIN CONFORMATION;

EID: 0035968334     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101896200     Document Type: Article

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