Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): Mechanisms that control enzyme activity, transcription, and mRNA stability

Critical Reviews in Eukaryotic Gene Expression

Volumn 6, Issue 4, 1996, Pages 391-411

  Vincenti, Matthew P ^a   White, Lori A ^a   Schroen, Daniel J ^a   Benbow, Ulrike ^a   Brinckerhoff, Constance E ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

connective tissue; cytokines; enzyme activation and inhibition; glucocorticoids; growth factors; phorbol esters; retinoids; transfection

Indexed keywords

COLLAGENASE; CYTOKINE; GLUCOCORTICOID; GROWTH FACTOR; RETINOID; RNA;

ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION REGULATION; GENE INDUCTION; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION;

EID: 0029731750     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevEukarGeneExpr.v6.i4.40     Document Type: Review

References (169)

1. Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Seiki M (1994): A matrix metalloprotease expressed on the surface of invasive tumour cells. Nature 370:61-65.
2. Woessner JF, Jr. (1991): Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145-2154.
3. Birkedal-Hansen H, Werb Z, Welgus H, Van Wort H (1992): Matrix Metalloproteinases and Inhibitors New York: Gustav Fischer Verlag.
4. Libby P (1995): Molecular bases of the acute coronary syndromes. Circulation 91:2844-2850.
5. Ye S, Watts GF, Mandalia S, Humphries SE, Henney AM (1995): Genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis. Br Hear J 73:209-215.
6. James TW, Wagner R, White LA, Zwolak RM, Brinckerhoff CE (1993): Induction of collagenase and stromelysin gene expression by mechanical injury in a vascular smooth muscle-derived cell line. J Cell Physiol 157:426-437.
7. Freije JMP, Diez-Itza I, Balbin M, Sanchez LM, Blasco R, Tolivia J, Otin-Lopez C (1994): Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinoma. J Biol Chem 269:16766-16773.
8. Stetler-Stevenson WG, Liotta LA, Kleiner DE (1993): Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J 7:1434-1441.
9. Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhacer OL, Chenard MP, Rio MC, Chambon P (1990): A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinoma. Nature 348:699-704.
10. Basset P, Wolf C, Chambon P (1993): Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review. Breast Cancer Res 24:195-193.
11. Biswas C (1985): Matrix influences on the tumor cell stimulation of fibroblast collagenase production. J Cell Biochem 28:39-45.
12. Konig H, Ponta H, Rahmsdorf HJ, Herrlich P (1992): Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J 11:2241-2246.
13. Harris EDJ (1990): Rheumatoid arthritis: pathophysiology and implications for therapy. N Engl J Med 322: 1277-1289.
14. Harris EDJ (1993): The etiology and pathogenenesis of rheumatoid arthritis. In Kelly WN, Harris ED Jr, Ruddy S, Sledge CB (eds): "Textbook of Rheumatology." Philadelphia: WB Saunders pp 833-873.
15. Werb Z, Alexander CM (1993): Proteinases and matrix degradation. In Kelly WN, Harris ED, Jr, Ruddy S, Sledge CB (eds): "Textbook of Rheumatology." Philadelphia: WB Saunders.
16. Brinckerhoff CE (1992): Regulation of metalloproteinase gene expression: implications for osteoarthritis. Crit Rev Eukaryotic Gene Expression 2:145-164.
17. Brandt KD, Mankin HJ (1993): Pathogenesis of osteoarthritis. In Kelly WN, Harris ED Jr, Ruddy S, Sledge CB (eds): "Textbook of Rheumatology." Philadelphia: WB Saunders pp 1355-1373.
18. Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL (1990): Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J Biol Chem 265:11421-11424.
19. Gross J, Lapiere C (1962): Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci USA 48:1014-1022.
20. Brinckerhoff CE, Plucinska IM, Sheldon LA, O'Connor GT (1986): Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate but not by all-trans-retinoic acid or dexamethasone. Biochemistry 25:6378-6384.
21. Fini ME, Plucinska IM, Mayer AS, Gross RH, Brinckerhoff CE (1987): A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix. Biochemistry 26:6157-6165.
22. Goldberg G, Wilhelm SM, AK, Bauer EA, Grant GA, Eisen AZ (1986): Human fibroblast collagenase: complete primary structure and homology to an oncogene transformation-induced rat protein. J Biol Chem 261:5645-5650.
23. Whitham SE, Murphy G, Angel P, Rahmsdorf H-J, Smith BJ, Lyons A, Harris TJR, Reynolds JJ, Herrlich P, Docherty AJP (1986): Comparison of human stromelysin and collagenase by cloning and sequence analysis. Biochem J 240:913-916.
24. Quinn CO, Scott DK, Brinckerhoff CE, Matrisian LM, Jeffrey JJ, Partridge NC (1990): Rat collagenase: cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. J Biol Chem 265:22342-22347.
25. Schorpp M, Mattei MG, Herr I, Gack S, Schaper J, Angel P (1995): Structural organization and chromosomal localization of the mouse collagenase type I gene. Biochem J 308:211-217.
26. Nagase H, Brinckerhoff CE, Vater CA, Harris ED, Jr. (1983): Biosynthesis and secretion of procollagenase by rabbit synovial fibroblasts. Biochem J 214:281-288.
27. Springman EB, Angleton EL, Birkedal-Hansen H, Van Wart HE (1990): Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation. Proc Natl Acad Sci USA 87:364-8.
28. Van Wart HE, Birkedal-Hansen H (1990): The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl Acad Sci USA 87:5578-5582.
29. Vallee BL, Auld DS (1990): Zinc coordination, function and structure of zinc enzymes and other proteins. Biochemistry 29:5647-5659.
30. Matrisian LM (1990): Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6:121-125.
31. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA (1993): Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4:197-250.
32. Suzuki K, Enghild JJ, Morodomi T, Salvesen G, Nagase H (1990): Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry 29:10261-10270.
33. Murphy G, Nagase H, Brinckerhoff CE (1987): Relationship of procollagenase activator, stromelysin and matrix metalloproteinase 3. Collagen Relat Res 8:389-391.
34. Ito A, Nagase H (1988): Evidence that rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase. Arch Biochem Biophys 267:211-215.
35. Imai K, Yokohama Y, Nakanishi I, Ohuchi E, Fujii Y, Nakai N, Okada Y (1995): Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties. J Biol Chem 270:6691-6697.
36. Murphy G, Allan JA, Willenbrock F, Cockett MI, O'Donnell JP, Docherty AJP (1992): The role of the C-terminal domain in collagenase and stromelysin specificity. J Biol Chem 267:9612-9618.
37. Suzuki K, Lees M, Newlands GF, Nagase H, Woolley DE (1995): Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II. Biochem J 305:301-306.
38. Saarinen J, Kalkkinen N, Welgus HG, Kovanen PT (1994): Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. J Biol Chem 269:18134-18140.
39. Grant GA, Eisen AZ, Marmer BL, Roswit TT, Goldberg GI (1987): The activation of human skin fibroblast collagenase. Sequence identification of the major conversion products. J Biol Chem 262:5886-5889.
40. Reinemer P, Grams F, Huber R, Kleine T, Schnierer S, Piper M, Tschesche H, Bode W (1994): Structural implications for the role of the N terminus in the "superactivation" of collagenases. A crystallographic study. FEBS Lett 338:227-233.
41. Bode W, Reinemer P, Huber R, Kleine T, Schnierer S, Tschesche H (1994): The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J 13:1263-1269.
42. Vincenti MP, Clark IM, Brinckerhoff CE (1994): Using inhibitors of metalloproteinases to treat arthritis: easier said than done? Arthritis Rheum 37:1115-1126.
43. Willenbrock F, Murphy G (1994): Structure-function relationships in the tissue inhibitors of metalloproteinases. Am J Respir Crit Care Med 150:S165-170.
44. Yang TT, Hawkes SP (1992): Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts. Proc Natl Acad Sci USA 89:10676-10680.
45. Leco KJ, Khokha R, Pavloff N, Hawkes SP, Edwards DR (1994): Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem 269:9352-9360.
46. Apte SS, Olsen BR, Murphy G (1995): The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family. J Biol Chem 270:14313-14318.
47. Lelievre Y, Bouboutou R, Boiziau J, Faucher D, Achard D, Cartwright T (1990): Low molecular weight, sequenced based, collagenase inhibitor selectively block the interaction between collagenase and TIMP (tissue inhibitor of metalloproteinases). Matrix 10:292-299.
48. Cawston T, Mercer E, deSilvia M, Hazleman, BL (1984): Metalloproteinases and collagenase inhibitors in rheumatoid synovoal fluid. Arthritis Rheum 27:284-290.
49. Bauer EA, Seltzer JL, Eisen AZ (1982): Inhibition of collagen degradative enzymes by retinoic acid in vitro. J Am Acad Dermatol 6:603-607.
50. Clark SD, Kobayashi DK, Welgus HG (1987): Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts. J Clin Invest 80:1280-1288.
51. 1 serum protein which specifically inhibits human collagenase. Nature 261:325-327.
52. 2-macroglobulin in rheumatoid synovial fluid: a possible regulatory mechanism of collagenase activity in vivo. J Biochem 73:897-900.
53. 2M in the rheumatoid synovial membrane. Ann Rheum Dis 41:520-526.
54. Delany AM, Brinckerhoff CE (1992): Post-transcriptional regulation of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts. J Cell Biochem 50:400-410.
55. Vincenti MP, Coon CI, Lee O, Brinckerhoff CE (1994): Regulation of collagenase gene expression by IL-1 beta requires transcriptional and post-transcriptional mechanisms. Nucleic Acids Res 22:4818-4827.
56. Auble DT, Brinckerhoff CE (1991): The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts. Biochemistry 30:4629-4635.
57. Gutman A, Wasylyk B (1990): The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites. EMBO J 9:2241-2246.
58. Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M (1987): Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739.
59. Angel P, Baumann I, Stein B, Delius H, Rahmsdorf H-J, Herrlich P (1987): 12-O-Tetradecanoyl-Phorbol-13-Acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region. Mol Cell Biol 7:2256-2266.
60. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M (1989): Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature 337:661-663.
61. Chamberlain SH, Hemmer RM, Brinckerhoff CE (1993): Novel phorbol ester response region in the collagenase promoter binds Fos and Jun. J Cell Biochem 52:337-351.
62. White LA, Brinckerhoff CE (1995): Two AP-1 elements in the collagenase promoter have differential effects on basal and phorbol-induced transcription and bind JunD, c-Fos and Fra-2. Matrix Biology 14:715-725.
63. Schonthal A, Herrlich P, Rahmsdorf HJ, Ponta H (1988): Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 54:325-334.
64. Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M (1988): Oncogene jun encodes a sequence-specific frans-activator similar to AP-1. Nature 332:166-171.
65. Rauscher F, Voulalas PJ, Franza BJ, Curran T (1988): Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev 2:1687-1699.
66. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P (1988): c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 55:917-924.
67. Curran T, Franza BJ (1988): Fos and Jun: the AP-1 connection. Cell 55:395-397.
68. Risse G, Jooss K, Nueberg M, Bruller HJ, Muller R (1989): Asymmetrical Recognition of the Palindromic AP-1 Binding Site (TRE) by Fos Protein Complexes. EMBO J 8:3825-3832.
69. Kerppola T, Curran T (1995): Zen and the art of Fos and Jun. Nature 373:199-200.
70. Glover JN, Harrison SC (1995): Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature 373:257-261.
71. Buttice G, Quinones S, Kurkinen M (1991): The AP-1 site is required for basal expression but is not necessary for TPA-responsiveness of the human stromelysin gene. Nucleic Acids Res 19:3723-3731.
72. Imai S, Fujino T, Nishibayashi S, Manabe T, Takano T (1994): Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts. Mol Cell Biol 14:7182-7194.
73. Mitchell TI, Coon CI, Brinckerhoff CE (1991): Serum amyloid A (SAA3) produced by rabbit synovial fibroblasts treated with phorbol esters or Interleukin 1 induces synthesis of collagenase and is neutralized with specific antiserum. J Clinical Invest 87:1177-1185.
74. Nakabeppu Y, Ryder K, Nathans D (1988): DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell 55:907-915.
75. Karin M (1995): The regulation of AP-1 activity by mitogen-activated protein kinases. Cell 270:16483-16486.
76. Dinarello CA (1991): Interleukin-1 and interleukin-1 antagonism. Blood 77:1627-1652.
77. Arend WP, Dayer J-M (1993): Cytokines and growth factors. In Kelly WN HEJ, Ruddy S, Sledge CB (eds): "Textbook of Rheumatology." Philadelphia: WB Saunders pp 227-247.
78. Chandrasekhar S, Harvey AK (1992): Differential regulation of metalloprotease steady-state mRNA levels by IL-1 and FGF in rabbit articular chondrocytes. FEBS Lett 296:195-200.
79. Smith RJ, Justen JM, Ulrich RG, Lund JE, Sam LM (1992): Induction of neutral proteinase and prostanoid production in bovine nasal chondrocytes by interleukin-1 and tumor necrosis factor alpha: modulation of these cellular responses by interleukin-6 and platelet-derived growth factor. Clin Immunol Immunopathol 64:135-144.
80. Bandara G, Lin CW, Georgescu HI, Mendelow D, Evans CH (1989): Chondrocyte activation by interleukin-1: analysis of the synergistic properties of fibroblast growth factor and phorbol myristate acetate. Arch Biochem Biophys 274:539-547.
81. Lin CW, Georgescu HI, Phillips SL, Evans CH (1989): Cycloheximide inhibits the induction of collagenase mRNA in chondrocytes exposed to synovial factors or recombinant interleukin-1. Agents and Actions 27:445-447.
82. Kumkumian GK, Lafyatis R, Remmers EF, Case JP, Kim SJ, Wilder RL (1989): Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription. J Immunol 143:833-837.
83. Lafyatis R, Kim SJ, Angel P, Roberts AB, Sporn MB, Karin M, Wilder RL (1990): Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5′ activator protein-1-binding site. Mol Endocrinology 4:973-980.
84. Ohshima M, Otsuka K, Suzuki K (1994): Interleukin-1 beta stimulates collagenase production by cultured human periodontal ligament fibroblasts. J Periodontal Res 29:421-429.
85. McCachren SS, Greer PK, Niedel JE (1989): Regulation of human synovial fibroblast collagenase messenger RNA by interleukin-1. Arthritis Rheum 32:1539-1545.
86. MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson NI (1992): Differential effects of IL-1 and TNF alpha on the expression of stromelysin, collagenase and their natural inhibitor, TIMP, in rheumatoid human synovial fibroblasts. Matrix Suppl 1:198-199.
87. Alvaro-Gracia JM, Zvaifler NJ, Firestein GS (1990): Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. J Clin Invest 86:1790-1798.
88. Conca W, Auron PE, Aoun-Wathne M, Bennett N, Seckinger P, Welgus HG, Goldring SR, Eisenberg SP, Dayer JM, Krane SM, et al. (1991): An interleukin 1 beta point mutant demonstrates that jun/fos expression is not sufficient for fibroblast metalloproteinase expression. J Biol Chem 266:16265-16268.
89. Lark MW, Walakovits LA, Shah TK, Vanmiddlesworth J, Cameron PM, Lin TY (1990): Production and purification of prostromelysin and procollagenase from IL-1 beta-stimulated human gingival fibroblasts. Connect Tissue Res 25:49-65.
90. Richards CD, Rafferty JA, Reynolds JJ, Saklatvala J (1991): Porcine collagenase from synovial fibroblasts: cDNA sequence and modulation of expression of RNA in vitro by various cytokines. Matrix 11:161-167.
91. Yang M, Kurkinen M (1994): Different mechanisms of regulation of the human stromelysin and collagenase genes. Analysis by a reverse-transcription-coupled-PCR assay. Eur J Biochem 222:651-658.
92. Farrar MA, Schreiber RD (1993): The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 11:571-611.
93. Paul WE, Seder RA (1994): Lymphocyte responses and cytokines. Cell 76:241-251.
94. Lacraz S, Nicod L, Galve-de Rochemonteix B, Baumberger C, Dayer JM, Welgus HG (1992): Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4. J Clin Invest 90:382-388.
95. Shapiro SD, Campbell EJ, Kobayashi DK, Welgus HG (1990): Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-gamma. J Clin Invest 86:1204-1210.
96. Andrews HJ, Bunning RA, Plumpton TA, Clark IM, Russell RG, Cawston TE (1990): Inhibition of interleukin-1-induced collagenase production in human articular chondrocytes in vitro by recombinant human interferon-gamma. Arthritis Rheum 33:1733-1738.
97. Unemori EN, Bair MJ, Bauer EA, Amento EP (1991): Stromelysin expression regulates collagenase activation in human fibroblasts. Dissociable control of two metalloproteinases by interferon-gamma. J Biol Chem 266:23477-23482.
98. Varga J, Yufit T, Brown RR (1995): Inhibition of collagenase and stromelysin gene expression by interferon-gamma in human dermal fibroblasts is mediated in part via induction of tryptophan degradation. J Clin Invest 96:475-181.
99. Boonstra J, Rijken P, Humbel B, Cremers F, Verkleij A, van Bergen en Henegouwen P (1995): The epidermal growth factor. Cell Biol Int 19:413-430.
100. Meyer-Ingold W, Eichner W (1995): Platelet-derived growth factor. Cell Biol Int 19:389-398.
101. Yoshida K, Tsujino T, Yasui W, Kameda T, Sano T, Nakayama H, Toge T, Tahara E (1990): Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28. Jpn J Cancer Res 81:793-798.
102. Mitchell PG, Cheung HS (1991): Tumor necrosis factor alpha and epidermal growth factor regulation of collagenase and stromelysin in adult porcine articular chondrocytes. J Cell Physiol 149:132-140.
103. van der Zee E, Everts V, Hoeben K, Beertsen W (1993): Interleukin-1 alpha and epidermal growth factor synergistically enhance the release of collagenase by periosteal connective tissue in vitro. Matrix 13:389-398.
104. Cirocolo A, Welgus HG, Pierce GF, Kramer J, Strunk RC (1991): Differential regulation of the expression of proteinases/antiproteinases in fibroblasts. J Biol Chem 19:12283-12288.
105. Conca W, Kaplan PB, Krane SM (1989): Increases in levels of procollagenase mRNA in human fibroblasts induced by interleukin-1, tumor necrosis factor-alpha, or serum follow c-jun expression and are dependent on new protein synthesis. Trans Assoc Am Physicians 102:195-203.
106. Vincenti MP, Coon CI, White LA, Barchowsky A, Brinckerhoff CE (1996): Transcriptional activation of the interstitial collagenase gene (MMP-1) in IL-1-stimulated synovial fibroblasts is regulated by Srcrelated tyrosine kinases. Arthritis Rheum 39:574-582.
107. Whitelock JM, Paine ML, Gibbins JR, Kefford RF, O'Grady RL (1993): Multiple levels of post-transcriptional regulation of collagenase (matrix metalloproteinase 1) in an epithelial cell line. Immunol Cell Biol 71:39-17.
108. Shaw G, Kamen R (1986): A conserved AU sequence from the 3′untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659-997.
109. Brewer G (1991): An A+U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol Cell Biol 12:2460-2466.
110. Wlaschek M, Heinen G, Poswig A, Schwarz A, Krieg T, Scharffetter-Kochanek K (1994): UVA-induced autocrine stimulation of fibroblast-derived collagenase/MMP-1 by interrelated loops of interleukin-1 and interleukin-6. Photochem Photobiol 59:550-556.
111. Stein B, Rahmsdorf HJ, Steffen A, Litfin M, Herrlich P (1989): UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol 9:5169-5181.
112. Petersen MJ, Hansen C, Craig S (1992): Ultraviolet A irradiation stimulates collagenase production in cultured human fibroblasts. J Invest Dermatol 99:440-444.
113. Devary Y, Gottlieb RA, Lau LF, Karin M (1991): Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol 11:2804-2811.
114. Engelberg D, Klein C, Martinetto H, Struhl K, Karin M (1994): The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell 77:381-390.
115. Maytin EV (1995): Heat shock proteins and molecular chaperones: implications for adaptive responses in the skin. J Invest Dermatol 104:448-455.
116. Vance BA, Kowalski CG, Brinckerhoff CE (1989): Heat shock of rabbit synovial fibroblasts increases expression of mRNAs for two metalloproteinases, collagenase and stromelysin. J Cell Biol 108:2037-2043.
117. Hitraya EG, Varga J, Jimenez SA (1995): Heat shock of human and dermal fibroblasts induces delayed up-regulation of collagenase gene expression. Biochem J 308:743-747.
118. Schutze S, Machleidt T, Kronke M (1994): The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction. J Leukoc Biol 56:533-541.
119. Takahashi S, Sato T, Ito A, Ojima Y, Hosono T, Nagase H, Mori Y (1993): Involvement of protein kinase C in the interleukin 1 alpha-induced gene expression of matrix metalloproteinases and tissue inhibitor-1 of metalloproteinases (TIMP-1) in human uterine cervical fibroblasts. Biochim Biophys Acta 1220:57-65.
120. Strissel KJ, Girard MT, West-Mays JA, Brinckerhoff CE, Fini ME (1995): Relative roles of serum amyloid A3 and IL-1 alpha in autocrine control of rabbit fibroblast collagenase synthesis. Submitted.
121. West-Mays JA, Strissel KJ, Sadow PM, Fini ME (1995): Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin la autocrine loop. Proc Natl Acad Sci USA 92:6768-6772.
122. Sudbeck BD, Parks WC, Welgus HG, Pentland AP (1994): Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities. J Biol Chem 269:30022-30029.
123. Courtneidge SA, Fumagalli S, Koegl M, Superti-Furga G, Twamley-Stein GM (1993): The Src family of protein tyrosine kinases: regulation and functions. Dev Suppl:57-64.
124. Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ (1995): Integration of MAP kinase signal transduction pathways at the serum response element. Science 269:403-407.
125. Derijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ (1995): Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685.
126. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJP, Angel PJKH (1987): Transforming growth factor β modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 6:1899-1904.
127. Kerr LD, Miller DB, Matrisian LM (1990): TGFβ1 inhibition of transin/stromelysin gen expression is mediated through a Fos binding sequence. Cell 61:267-278.
128. Kramer IM, Koornneef I, de Laat SW, van den Eijndenvan Raaij AJ (1991): TGF-beta 1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CC164 cells. EMBO J 10:1083-1089.
129. Brinckerhoff CE, McMillan RM, Dayer J-M, Harris J (ed) (1980): Inhibition by retinoic acid of collagenase production in rheumatoid synovial cells. N Engl J Med 303:432-436.
130. Brinckerhoff CE, Harris J (ed) (1981): Modulation by retinoic acid and corticosteroids of collagenase production by rabbit synovial fibroblasts treated with phorbol myristate acetate or poly(ethylene glycol). Biochim Biophys Acta 677:424-432.
131. Bauer EA, Seltzer JL, Eisen AZ (1983): Retinoic acid inhibition of collagenase and gelatinase expression in human skin fibroblasts cultures. Evidence for a dual mechanism. J Invest Dermatol 81:162-169.
132. Brinckerhoff CE, Coffey JW, Sullivan AC (1983): Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid. Science 221:756-758.
133. Haraoui B, Wilder RL, Allen JB, Sporn MB, Helfgott RK, Brinckerhoff CE (1985): Dose-dependent suppression by the synthetic retinoid 4-hydroxyphenyl retinamide of streptococcal cell wall-induced arthritis in rats. Int J Immunopharmacol 7:903-916.
134. Parker MG (1993): Steroid and related receptors. Curr Opin Cell Biol 5:499-504.
135. Giguere V (1994): Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling. Endocr Rev 15:61-79.
136. Mangelsdorf DJ, Umesono K, Evans RM (1994): The retinoid receptors. In Sporn MB, Roberts AB, Goodman DS (eds): "The retinoids: Biology, Chemistry and Medicine." New York: Raven Press pp 319-349.
137. Kastner P, Chambon P, Leid M (1994): Role of nuclear retinoic acid receptors in the regulation of gene expression. In Blomhoff R (ed): "Vitamin A in Health and Disease." New York: Marcel Dekker pp 189-238.
138. Chen JD, Evans RM (1995): A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457.
139. Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG (1995): Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404.
140. Kurokawa R, Soderstrom M, Horlein A, Halachml S, Brown M, Rosenfeld MG, Glass CK (1995): Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377:451-454.
141. Perlmann T, Vennstrom B (1995): The sound of silence. Nature 377:387-388.
142. Pfahl M (1993): Nuclear receptor/AP-1 interaction. Endocr Rev 14:651-658.
143. Truss M, Beato M (1993): Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev 14:459-479.
144. Keaveney M, Berkenstam A, Feigenbutz M, Vriend G, Stunnenberg HG (1993): Residues in the TATA-binding protein required to mediate a transcriptional response to retinoic acid in EC cells. Nature 365:562-566.
145. Sadovsky Y, Webb P, Lopez G, Baxter JD, Fitzpatrick PM, Gizang-Ginsberg E, Cavailles V, Parker MG, Kushner PJ (1995): Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein. Mol Cell Biol 15:1554-1563.
146. Um M, Li C, Manley JL (1995): The transcriptional repressor even-skipped interacts directly with TATA-binding protein. Mol Cell Biol 15:5007-5016.
147. Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW (1992): Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem 267:17617-17623.
148. Baniahmad A, Ha I, Reinberg D, Tsai S, Tsai MJ, O'Malley BW (1993): Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene depression and activation by thyroid hormone. Proc Natl Acad Sci USA 90:8832-8836.
149. Hadzic E, Desai-Yajnik V, Helmer E, Guo S, Wu S, Koudinova N, Casanova J, Raaka BM, Samuels HH (1995): A 10-amino-acid sequence in the N-terminal A/B domain of thyroid hormone receptor alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB. Mol Cell Biol 15:4507-4517.
150. Roberts SG, Green MR (1995): Transcription. Dichotomous regulators (news; comment). Nature 375:105-106.
151. Berkenstam A, Ruiz MM, Barettino D, Horikoshi M, Stunnenberg HG (1992): Cooperativity in transactivation between retinoic acid receptor and TFIID requires an activity analogous to E1A. Cell 69:401-412.
152. Jonat C, Rahmsdorf HJ, Park KK, Cato AC, Gebel S, Ponta H, Herrlich P (1990): Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189-1204.
153. Schule R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, Verma IM, Evans RM (1990): Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62:1217-1226.
154. Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M (1990): Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215.
155. Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR (1990): Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272.
156. Miner JN, Yamamoto KR (1991): Regulatory crosstalk at composite response elements. Trends Biochem Sci 16:423-426.
157. Nicholson RC, Mader S, Nagpal S, Leid M, Rochette-Egly C, Chambon P (1990): Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. Embo J 9:4443-4454.
158. Yang-Yen HF, Zhang XK, Graupner G, Tzukerman M, Sakamoto B, Karin M, Pfahl M (1991): Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation. New Biol 3:1206-1219.
159. Pan L, Chamberlain SH, Auble DT, Brinckerhoff CE (1992): Differential regulation of collagenase gene expression by retinoic acid receptors - alpha, beta, and gamma. Nucleic Acids Res 20:3105-3111.
160. Pan L, Brinckerhoff CE (1994): Inhibition of collagenase gene expression in synovial fibroblasts by all-trans and 9-cis retinoic acid. Ann NY Acad Sci 732:335-347.
161. Pan L, Eckhoff C, Brinckerhoff CE (1995): Suppression of collagenase gene expression by all-trans and 9-cis retinoic acid is ligand dependent and requires both RARs and RXRs. J Cell Biochem 57:575-589.
162. Schule R, Rangarajan P, Yang N, Kliewer S, Ransone LJ, Bolado J, Verma IM, Evans RM (1991): Retinoic acid is a negative regulator of AP-1-responsive genes. Proc Natl Acad Sci USA 88:6092-6096.
163. Fondell JD, Roy AL, Roeder RG (1993): Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression. Genes Dev 7:1400-1410.
164. Gaire M, Magbanua Z, McDonnell S, McNeil L, Lovett DH, Matrisian LM (1994): Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J Biol Chem 269:2032-2040.
165. Anglard P, Melot T, Guerin E, Thomas G, Basset P (1995): Structure and promoter characterization of the human stromelysin-3 gene. J Biol Chem 270:20337-20344.
166. Sato H, Kida Y, Mai M, Endo Y, Sasaki T, J. T,(??) Seiki M (1992): Expression of gene encoding type IV collagen-degrading metalloproteinase and tissue inhibitors of metalloproteinases in various human tumor cells. Oncogene 7:77-83.
167. Rodgers WH, Osteen LM, Matrisian L, Navre M, Giudice LC, Gorstein F (1993): Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle. Am J Obstet Gynecol 168:253-260.
168. Takino T, Sato H, Shinagawa A, Seiki M (1995): Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) from a human placenta cDNA library. J Biol Chem 270:23013-23030.
169. Takino T, Sato H, Yamamoto E, Seiki M (1995): Cloning of a human gene