Production of brominating intermediates by myeloperoxidase. A transhalogenation pathway for generating mutagenic nucleobases during inflammation

Journal of Biological Chemistry

Volumn 276, Issue 11, 2001, Pages 7867-7875

  Henderson, Jeffrey P ^a   Byun, Jaeman ^a   Williams, Michelle V ^a   Mueller, Dianne M ^a   McCormick, Michael L ^b   Heinecke, Jay W ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c Nutrition and Lipid Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; CHLORINATION; DNA; ENZYMES; MUTAGENESIS;

NEUTROPHILS; PHAGOCYTES;

BROMINE COMPOUNDS;

BROMINE DERIVATIVE; BROMOCHLORINE; CELL NUCLEUS DNA; CHLORIDE ION; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; NUCLEIC ACID BASE; UNCLASSIFIED DRUG; 5 BROMOURACIL; BROMINE; DEOXYCYTIDINE; MUTAGENIC AGENT; PEROXIDASE; URACIL;

ARTICLE; BROMINATION; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MUTAGENESIS; NEUTROPHIL; OXIDATION; PHAGOCYTOSIS; PRIORITY JOURNAL; REACTION ANALYSIS; SIGNAL TRANSDUCTION; DNA DAMAGE; INFLAMMATION; METABOLISM; OXIDATION REDUCTION REACTION;

BROMINE; BROMOURACIL; DEOXYCYTIDINE; DNA DAMAGE; HUMANS; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; INFLAMMATION; MUTAGENS; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; URACIL;

EID: 0035896545     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M005379200     Document Type: Article

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