Sp1 and Krüppel-like factor family of transcription factors in cell growth regulation and cancer

Journal of Cellular Physiology

Volumn 188, Issue 2, 2001, Pages 143-160

  Black, Adrian R ^a   Black, Jennifer D ^a   Azizkhan Clifford, Jane ^b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROID KRUPPEL LIKE FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1;

AMINO ACID SEQUENCE; APOPTOSIS; BINDING AFFINITY; CANCER; CARCINOGENESIS; CELL GROWTH; GENE EXPRESSION; GROWTH REGULATION; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ANIMALS; CELL DIVISION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; NEOPLASMS; REPRESSOR PROTEINS; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 0034929708     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.1111     Document Type: Review

References (269)

1. Positive- and negative-acting kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo
2. p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: Involvement of the small GTPase rhoA
3. Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription
4. Follicle stimulating hormone-regulated expression of serum/glucocorticoid-inducible kinase in rat ovarian granulosa cells: A functional role for the Sp1 family in promoter activity
5. Expression and localization of serum/glucocorticoid-induced kinase in the rat ovary: Relation to follicular growth and differentiation
6. Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor
7. Sp3 is a transcriptional repressor of TGF-beta receptors
8. DNA damage and the DNA-activated protein kinase
9. High Sp1/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transformation correlate with the activation of the HPV-16 promoter
10. Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity
11. FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes
12. FKLF-2: A novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes
13. Transcriptional factors for specific globin genes
14. Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor beta4 subunit gene
15. p53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism
16. Protein kinase C-mediated regulation of the cell cycle
17. Transcriptional regulation of growth-related genes by E2F and Sp1
18. Regulation of E2F: A family of transcription factors involved in proliferation control
19. Growth/cell cycle regulation of Sp1 phosphorylation
20. Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter
21. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation
22. Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1
23. A putative binding site for Sp1 is involved in transcriptional regulation of CYP17 gene expression in bovine ovary
24. Transcription factor Sp3 is essential for post-natal survival and late tooth development
25. The tissue-dependent keratin 19 gene transcription is regulated by GKLF/KLF4 and Sp1
26. Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
27. Oncogene-induced upregulation of Caco-2 cell proliferation involves IGF-II gene activation through a protein kinase C-mediated pathway
28. A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial MvlLu cells
29. Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene
30. Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)- lipoxygenase
31. The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator
32. Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells
33. Modulation of human alpha1(I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro
34. Induction of 12-lipoxygenase expression by transforming growth factor- alpha in human epidermoid carcinoma A431 cells
35. Ectopic expression of truncated Sp1 transcription factor prolongs the S phase and reduces the growth rate
36. Up-regulation of gut-enriched kruppel-like factor by interferon-gamma in human colon carcinoma cells
37. Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat
38. EGF stimulates gastrin promoter through activation of Sp1 kinase activity
39. Transcriptional regulation of endothelial nitric-oxide synthase by an interaction between casein kinase 2 and protein phosphatase 2A
40. Upregulation of endothelial nitric oxide synthase promoter by PI3K{gamma}/Jak2/MEK-1-dependent pathway
41. Sp1 binding is inhibited by (m)Cp(m)CpG methylation
42. A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells
43. Insulin-like growth factor-I regulates transcription of the elastin gene through a putative retinoblastoma control element. A role for Sp3 acting as a repressor of elastin gene transcription
44. TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth
45. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth
46. Three conserved transcriptional repressor domains are a defining feature of the TIEG subfamily of Sp1-like zinc finger proteins
47. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1
48. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells
49. Novel role for Sp1 in phorbol ester enhancement of human platelet thromboxane receptor gene expression
50. Decreased expression of the gut-enriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients
51. The biology of the mammalian Kruppel-like family of transcription factors
52. Association of p107 with Sp1: Genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription
53. Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between Smads and Sp1
54. An inhibitor domain in Sp3 regulates its glutamine-rich activation domains
55. Basic transcription element-binding protein (BTEB) is a thyroid hormone- regulated gene in the developing central nervous system. Evidence for a role in neurite outgrowth
56. HPV16 E6 oncoprotein stimulates the transforming growth factor-beta 1 promoter in fibroblasts through a specific GC-rich sequence
57. Mechanisms of transcriptional activation of bcl-c2 gene expression by 17beta-estradiol in breast cancer cells
58. Control of eukaryotic messenger RNA synthesis by sequence-specific DNA- binding proteins
59. Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs
60. Transforming growth factor-betal induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts
61. Expression of early growth response genes in human prostate cancer
62. GLUT1 glucose transporter gene transcription is repressed by Sp3. Evidence for a regulatory role of Sp3 during myogenesis
63. TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): Evidence of multiple transcripts from alternate promoters
64. Smad2, smad3 and smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
65. Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression
66. Gender-related differences in vascular smooth muscle cell proliferation: Implications for prevention of atherosclerosis
67. Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: Transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF
68. Increase of GKLF messenger RNA and protein expression during progression of breast cancer
69. Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium
70. A retinoblastoma susceptibility gene product, RB, targeting protease is regulated through the cell cycle
71. The regulation of cyclin D1 expression in senescent human fibroblasts
72. Distal Sp3 binding sites in the hIGBP-1 gene promoter suppress transcriptional repression in decidualized human endometrial stromal cells: Identification of a novel Sp3 form in decidual cells
73. Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters
74. A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells
75. Transcriptional regulation of the p21((WAF1/CIP1)) gene
76. Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction
77. Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis
78. Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions
79. The same nuclear proteins bind the proximal CACCC box of the human beta-globin promoter and a similar sequence in the enhancer
80. Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin- 1 in human vascular endothelial cells
81. B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays
82. Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression
83. Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1
84. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene
85. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening
86. Cloning by recognition site screening of two novel GT box binding proteins: A family of Sp1 related genes
87. Sp1-mediated transcriptional activation is repressed by Sp3
88. Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3
89. Modulation of Sp1 activity by a cyclin A/CDK complex
90. Mitotic arrest with nocodazole induces selective changes in the level of O-linked N-acetylglucosamine and accumulation of incompletely processed N-glycans on proteins from HT29 cells
91. Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N- acetylglucosa-minidase inhibitor O-(2-acetamido-2-deoxy-D- glucopyranosylidene)amino-N-phenylcarbamate
92. Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility
93. The hallmarks of cancer
94. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury
95. Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence
96. Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells
97. Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: Analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis
98. Structure and expression of the promoter for the human type II transforming growth factor-beta receptor
99. Molecular cloning and functional analysis of the murine bax gene promoter
100. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene
101. Overlapping pathways mediate the opposing actions of tumor necrosis factor-alpha and transforming growth factor-beta on alpha 2(I) collagen gene transcription
102. Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor betal, and tissue factor and also cell growth and invasion activities
103. O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation
104. GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
105. Transcriptional regulation of the elastin gene by insulin-like growth factor-I involves disruption of Sp1 binding. Evidence for the role of Rb in mediating Sp1 binding in aortic smooth muscle cells
106. Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter
107. pRB induces Sp1 activity by relieving inhibition mediated by MDM2
108. Multiple protein-DNA interactions in the TATAA-less mouse thymidylate synthase promoter
109. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain
110. c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1
111. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F
112. Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement
113. Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells
114. Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription
115. Activation of the second promoter of the transforming growth factor-beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences
116. The retinoblastoma gene product regulates Sp1-mediated transcription
117. Transcriptional activation of transforming growth factor betal and its receptors by the Kruppel-like factor Zf9/ core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury
118. A novel Sp1-related cis element involved in intestinal alkaline phosphatase gene transcription
119. Cloning of GT box-binding proteins: A novel Sp1 multigene family regulating T-cell receptor gene expression
120. Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites
121. Expression of transforming growth factor-beta receptor type II and tumorigenicity in human breast adenocarcinoma MCF-7 cells
122. Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter
123. Transcription factors etsl, NF-kappa B, and Sp1 are major determinants of the promoter activity of the human protein kinase CK2alpha gene
124. Serum responsive gene expression mediated by Sp1
125. Enhanced Sp1 DNA-binding activity in murine keratinocyte cell lines and epidermal tumors
126. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis
127. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival
128. Identification and characterization of the putative retinoblastoma control element of the rat insulin-like growth factor binding protein-2 gene
129. Sp3 and Sp4 can repress transcription by competing with Sp1 for the core ciselements on the human ADH5/FDH minimal promoter
130. Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling
131. Initial sequencing and analysis of the human genome
132. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
133. Induction of p21WAF1 expression via Sp1-binding sites by tamoxifen in estrogen receptor-negative lung cancer cells
134. Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepato-cellular carcinoma
135. Sp1 is phosphorylated and its DNA binding activity down-regulated upon terminal differentiation of the liver
136. The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators
137. The cancer antiapoptosis mouse survivin gene: Characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression
138. Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site
139. Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites
140. In vitro transcription of the TATAA-less mouse thymidylate synthase promoter: Multiple transcription start points and evidence for bidirectionality
141. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction
142. Transcriptional activation of human 12-lipoxygenase gene promoter is mediated through Sp1 consensus sites in A431 cells
143. Suppression of growth and transformation and induction of apoptosis by EGR-1
144. The role of Sp1 in the differential expression of transforming growth factor-beta receptor type II in human breast adenocarcinoma MCF-7 cells
145. Start site selection by Sp1 in the TATA-less human Ha-ras promoter
146. Androgen induction of cyclin-dependent kinase inhibitor p21 gene: Role of androgen receptor and transcription factor Sp1 complex
147. Effects of three Sp1 motifs on the transcription of the FGF-4 gene
148. Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)
149. Sequence analysis of the promoter region of the glioblastoma derived T cell suppressor factor/transforming growth factor (TGF)-beta 2 gene reveals striking differences to the TGF-beta 1 and -beta 3 genes
150. BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: Potential interaction between BRCA1 and Sp1
151. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
152. Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions
153. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Kruppel-like transcription factors
154. Constitutive Fas ligand gene transcription in Sertoli cells is regulated by Sp1
155. Epidermal growth factor stimulation of the human gastrin promoter requires Sp1
156. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts
157. Role of nitric oxide in cancer biology
158. Epidermal growth factor and okadaic acid stimulate Sp1 proteolysis
159. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity
160. Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements including SP1 sites and a cyclic AMP responsive element in vascular endothelial cells
161. A unique cathepsin-like protease isolated from CV-1 cells is involved in rapid degradation of retinoblastoma susceptibility gene product, RB, and transcription factor SP1
162. Cell-growth regulation of the hamster dihydrofolate reductase gene promoter by transcription factor Sp 1
163. Retinoblastoma protein associates with Sp1 and activates the hamster dihydrofolate reductase promoter
164. Inducible expression of basic transcription element-binding protein 2 in proliferating smooth muscle cells at the vascular anastomotic stricture
165. Inducible expression of basic transcription factor-binding protein 2 (BTEB2), a member of zinc finger family of transcription factors, in cardiac allograft vascular disease
166. p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: Interaction between p53 and Sp1
167. The Kruppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact
168. Interaction between Sp1 and cell cycle regulatory proteins is important in transactivation of a differentiation-related gene
169. Regulation of erythroid Kruppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain
170. Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta
171. Role of PKC z in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression
172. GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk
173. Role of smad proteins and transcription factor Sp1 in p21Waf1/Cip1 regulation by transforming growth factor-beta
174. Sp1 mediates constitutive and transforming growth factor beta-inducible expression of urokinase type plasminogen activator receptor gene in human monocyte-like U937 cells
175. Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA
176. p53 represses SV40 transcription by preventing formation of transcription complexes
177. Transcription factor Sp1 is expressed by three different developmentally regulated messenger ribonucleic acids in mouse spermatogenic cells
178. Molecular cloning and characterization of the cyclic AMP-responsive ovine CYP11A1 (cholesterol side-chain cleavage) gene promoter: DNase 1 protection of conserved consensus elements
179. A tale of three fingers: The family of mammalian Sp/XKLF transcription factors
180. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation
181. Sp1 and Smad proteins cooperate to mediate TGF-beta1-induced alpha2(I) collagen expression in human glomerular mesangial cells
182. Transcription from a TATA-less promoter requires a multisubunit TFIID complex
183. Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: Role of estrogen receptor- Sp1 complexes
184. Bcl-c3 expression promotes cell survival following inter-leukin-4 deprivation and is controlled by AP1 and APl-like transcription factors
185. Stimulation of the preprothyrotropin-releasing hormone gene by epidermal growth factor
186. The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress
187. Cleavage of transcription factor SP1 by caspases during anti-IgM- induced B-cell apoptosis
188. Unequal nuclear Sp1/GC box DNA binding activity distinguishes proliferating from differentiated senescent or apoptotic cells
189. Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2
190. NF-kappaB inhibits expression of the alphal(I) collagen gene
191. Modulation of transcription factor Sp1 by cAMP-dependent protein kinase
192. O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions
193. Transcription factors of the Sp1 family: Interaction with E2F and regulation of the murine thymidine kinase promoter
194. Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1
195. Expression of the vascular endothelial growth factor gene is inhibited by p73
196. Identification of an estrogen-mediated deoxyribonucleic acid-binding independent transactivation pathway on the epidermal growth factor receptor gene promoter
197. Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene
198. The bidirectionally transcribed dihydrofolate reductase and rep-3a promoters are growth regulated by distinct mechanisms
199. Expression of the transcription factor lung Kruppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo
200. Characterization of the lung Kruppel-like transcription factor gene and upstream regulatory elements
201. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family
202. Klf4 is a transcription factor required for establishing the barrier function of the skin
203. The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250
204. Stimulation of human insulin receptor gene expression by retinoblastoma gene product
205. Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): Binding to the CAAT/GT box of the mouse lactoferrin gene promoter
206. Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif
207. Role of gut-enriched Kruppel-like factor in colonic cell growth and differentiation
208. Identification of the DNA sequence that interacts with the gut-enriched Kruppel-like factor
209. Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest
210. The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts
211. Estradiol reverses TGF-beta1-stimulated type IV collagen gene transcription in murine mesangial cells
212. Expression and regulatory function of the transcription factor Sp1 in the uterine endometrium at early pregnancy: Implications for epithelial phenotype
213. RFLAT-1: A new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes
214. Characterization and promoter analysis of the mouse gene for transcription factor Sp4
215. Sp1 and NF-Y are necessary and sufficient for growth-dependent regulation of the hamster thymidine kinase promoter
216. Transcription factor erythroid Kruppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation
217. Expression of the SRF gene occurs through a Ras/Sp/SRF-mediated-mechanism in response to serum growth signals
218. Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins
219. An N-terminal region of Sp1 targets its proteasome-dependent degradation in vitro
220. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts
221. Tissue, cell type, and breast cancer stage-specific expression of a TGF- beta inducible early transcription factor gene
222. Intestinal-enriched Kruppel like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation
223. Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility
224. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells
225. Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing
226. Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP Kinases and Sp1 sites in cardiac myocytes
227. Estrogen regulation of a transforming growth factor-beta inducible early gene that inhibits deoxyribonucleic acid synthesis in human osteoblasts
228. Target Detection Assay (TDA): A versatile procedure to determine DNA binding sites as demonstrated on SP1 protein
229. Expression of the gut-enriched Kruppel-like factor gene during development and intestinal tumorigenesis
230. Induction of Sp1 activity by prolactin and interleukin-2 in Nb2 T- cells: Differential association of Sp1-DNA complexes with Stats
231. The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/ platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1
232. Additive effect of Sp1 and Sp3 in regulation of the ED-L1E promoter of the EBV LMP 1 gene in human epithelial cells
233. Differential up-regulation of gap junction connexin 26 gene in mammary and uterine tissues: The role of Sp transcription factors
234. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
235. Basic Kruppel-like factor functions within a network of interacting haematopoietic transcription factors
236. Mammalian Kruppel-like transcription factors: More than just a pretty finger
237. Sp-1 binds promoter elements regulated by the RB protein and Sp-1- mediated transcription is stimulated by RB coexpression
238. Functional interactions between the retinoblastoma (Rb) protein and Sp- family members: Superactivation by Rb requires amino acids necessary for growth suppression
239. Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: Superactivation by Rb requires amino acids necessary for growth suppression
240. The role of Sp family members, basic Kruppel-like factor, and E box factors in the basal and IFN-gamma regulated expression of the human complement C4 promoter
241. Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member
242. Transcriptional activation of the porcine P450 11A insulin-like growth factor response element in MCF-7 breast cancer cells
243. The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter
244. The sequence of the human genome
245. A Sp1 binding site of the tumor necrosis factor alpha promoter functions as a nitric oxide response element
246. Transcriptional repression of p21(Waf1/Cip1/Sdi1) gene by c-jun through Sp1 site
247. Isolation and molecular characterization of the 5′-upstream region of the human TRAIL gene
248. Loss of LKLF function results in embryonic lethality in mice
249. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor
250. Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal lung development
251. BTEB2, a Kruppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene
252. Repression of the insulin receptor promoter by the tumor suppressor gene product p53: A possible mechanism for receptor overexpression in breast cancer
253. Transcriptional regulation of neurofilament expression by protein kinase
254. The multifaceted roles of nitric oxide in cancer
255. Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells
256. Regulation of human monoamine oxidase B gene by Sp1 and Sp3
257. Coordinate modulation of Sp1, NF-kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation
258. Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains
259. Genomic organization and chromosomal mapping of the bovine Fas/ APO-1 gene
260. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis
261. Mechanism of initiator-mediated transcription: Evidence for a functional interaction between the TATA-binding protein and DNA in the absence of a specific recognition sequence
262. Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases
263. Protein kinase CK2 down-regulates glucose-activated expression of the acetyl-CoA carboxylase gene
264. The gut-enriched Kruppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion
265. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression
266. The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter
267. Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta 1 stimulation of alpha 2(I)-collagen (COL1A2) transcription
268. Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor Sp1
269. Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenine-independent wnt-1-responsive gene