Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Diseases

Advances in Pharmacology

Volumn 38, Issue C, 1996, Pages 601-628

  Lieber, Charles S ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 1842409036     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)61001-7     Document Type: Article

References (187)

1. Ahmed S., Leo M.A., and Lieber C.S. Interactions between alcohol and β-carotene in patients with alcoholic liver disease. Am. J. Clin. Nutr. 60 (1994) 430-436
2. Alam S.Q., and Alam B.S. Lipid peroxide, a-tocopherol and retinoid levels in plasma and liver of rats fed diets containing β-carotene and 13-cis-retinoic acid. J. Nutr. 113 (1983) 2608-2614
3. Albano E., Tomasi A., Goria-Gatti L., Persson J.O., Terelius Y., Ingelman-Sundberg M., and Dianzani M.U. Role of ethanol-inducible cytochrome P-450 (P450IIE1) in catalyzing the free radical activation of aliphatic alcohols. Biochem. Pharmacol. 411 (1991) 1895-1902
4. Albano E., Tomasi A., Goria-Gatti L., Poli G., Vannini B., and Dianzani M.U. Free radical metabolism of alcohols in rat liver microsomes. Free Rad. Res. Commun. 3 (1987) 243-249
5. Aleynik S.I., Leo M.A., Ma X., Aleynik M.K., and Lieber C.S. Polyenylphosphati-dylcholine (PPC) prevents hepatic lipid peroxidation and attenuates associated injury induced by CCl4 in rats and by alcohol in baboons. Gastroenterology 108 (1995) A1025
6. Alpha-Tocopherol, β-carotene and Cancer Prevention Study Group. N. Engl. J. Med. 330 (1994) 1029-1035
7. Arai M., Gordon E.R., and Lieber C.S. Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa3 content and changes in phospholipids. Biochim. Biophys. Acta. 797 (1984) 320-327
8. Araujo F.B., Barbosa D.S., Hsin C.Y., Maranhao R.C., and Abdalla D.S.P. Evaluation of oxidative stress in patients with hyperlipidemia. Atherosclerosis 117 (1995) 61-71
9. ArnesjÖ B., Nilsson A., Barrowman J., and Borgström B. Intestinal digestion and absorption of cholesterol and lecithin in the human: Intubation studies with a fat-soluble reference substance. Scand. J. Gastroenterol. 4 (1969) 653-665
10. Badger T.M., Huang J., Ronis M., and Lumpkin C.K. Induction of cytochrome P450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high. Biochem. Res. Commun. 190 (1993) 780-785
11. Barclay L.R. The cooperative antioxidant role of glutathione with a lipid-soluble and a water-soluble antioxidant during peroxidation of liposomes initiated in the aqueous phase and in the lipid phase. J. Biol. Chem. 263 (1988) 16138-16142
12. Beskid M., Bialck J., Dzieniszewski J., Sadowski J., and Tlalka J. Effect of combined phenylbutazone and ethanol administration on rat liver. Exp. Pathol. 18 (1980) 487-491
13. Bjôrneboe G.E.A., Bôrneboe A., Hagen B.F., Morland J., and Drevon C.A. Reduced hepatic α-tocopherol content after long-term administration of ethanol to rats. Biochim. Biophys. Acta 918 (1987) 236-241
14. Bôrneboe G.E.A., Johnsen J., Bôrneboe A., Marklund S.L., Skylv N., Hoiseth A., Bache-Wiig J.E., Morland J., and Drevon C.A. Some aspects of antioxidant status in blood from alcoholics. Alcoholism Clin. Exp. Res. 12 (1988) 806-810
15. Borowsky S.A., and Lieber C.S. Interaction of methadone and ethanol metabolism. J. Pharmacol. Exp. Ther. 207 (1978) 123-129
16. Bücher T.H., and Klingenberg M. Wege des Wasserstoffs in der lebendigen Organisation. Angew. Chem. 70 (1958) 552-570
17. Burton G.W. Antioxidant action of carotenoids. J. Nutr. 119 (1989) 109-111
18. Burton G.W., and Ingold K.U. α-carotene: An unusual type of lipid antioxidant. Science 224 (1984) 569-573
19. Carmichael F.J., Saldivia V., Israel Y., Mckaigney J.P., and Orrego H. Ethanol-induced increase in portal hepatic blood flow: Interference by anesthetic agents. Hepatology 97 (1987) 89-94
20. Castillo T., Koop D.R., Kamimura S., Triadafilopoulos G., and Tsukamoto. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent micro-somal lipid peroxidation. Hepatology 16 (1992) 992-996
21. Cederbaum A.I. Oxygen radical generation by microsomes: Role of iron and implications for alcohol metabolism and toxicity. Free Rad. Bid. Med. 7 (1989) 559-567
22. Clot P., Bellorno G., Tabone M., Aricò S., and Albano E. Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis. Gastroenterology 108 (1995) 201-207
23. Conney A.H. Pharmacological implications of microsomal enzyme induction. Pharmacol. Rev. 19 (1967) 317-366
24. Dai Y., Rashba-Step J., and Cederbaum A.I. Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates. Biochemistry 32 (1993) 6928-6937
25. Dennery P.A., Kramer C.M., and Alpert S.E. Effect of fatty acid profiles on the susceptibility of cultured rabbit tracheal epithelial cells to hyperoxic injury. Am. J. Respir. Cell Mol. Biol. 3 (1990) 137-144
26. Dicker E., and Cederbaum A.I. Increased oxygen radical-dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption. FASEB J. 2 (1988) 2901-2906
27. Diehl A.M., Bisgaard H.C., Kren B.T., and Steer C.J. Ethanol interferes with regeneration-associated changes in biotransforming enzymes: A potential mechanism underlying ethanol's carcinogenicity?. Hepatology 13 (1991) 722-727
28. Diluzio N.R. Prevention of the acute ethanol-induced fatty liver by the simultaneous administration of anti-oxidants. Life Sci. 3 (1964) 113-119
29. Diluzio N.R. The role of lipid peroxidation and antioxidants in ethanol-induced lipid alterations. Exp. Mol. Pathol. 8 (1968) 394-402
30. Dipadova C., Worner T.M., Julkunen R.J.K., and Lieber C.S. Effects of fasting and chronic alcohol consumption on the first pass metabolism of ethanol. Gastroenterology 92 (1987) 1169-1173
31. Domschke S., Domschke W., and Lieber C.S. Hepatic redox state: Attenuation of the acute effects of ethanol induced by chronic ethanol consumption. Life Sci. 15 (1974) 1327-1334
32. Duce A.M., Ortiz P., Cabrero C., and Mato J.M. S-Adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 8 (1988) 65-68
33. Ekstrom G., and Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P- 450 (P-450IIE1). Biochem. Pharmacol. 38 (1989) 1313-1319
34. Eliasson E., Johansson I., and Ingelman-Sundberg M. Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures. Biochem. Biophys. Res. Commun. 150 (1988) 436-443
35. 6-methylguanine transferase. Carcinogenesis 9 (1988) 761-766
36. Faller J., and Fox I.H. Evidence for increased urate production by activation of adenine nucleotide turnover. N. Engl. J. Med. 307 (1982) 1598-1602
37. Farinati F., Zhou Z., Bellah J., Lieber C.S., and Garro A.J. Effect of chronic ethanol consumption on activation of nitrosopyrrolidine to a mutagen by rat upper alimentary tract, lung and hepatic tissue. Drug Metab. Dispos. 13 (1985) 210-214
38. Finkelstein J.D., and Martin J.J. Methionine metabolism in mammals: Adaptation to methionine excess. J. Biol. Chem. 261 (1986) 1582-1587
39. Forman M.R., Beecher G.R., Lanza E., Reichman M.E., Graubard B.I., Campbell, Marr T., Yong L.C., Judd J.T., and Taylor P.R. Effect of alcohol consumption on plasma carotenoid concentrations in premenopausal women: A controlled dietary study. Am. J. Clin. Nutr. 62 (1995) 131-135
40. Fox J.M. Polyene phosphatidylcholine: Pharmacokinetics after oral administration. In: Avogaro P., Macini M., Ricci G., and Paoletti R. (Eds). "Phospholipids and Atherosclerosis" (1983), Raven Press, New York
41. Garro A.J., and Lieber C.S. Alcohol and cancer. Annu. Rev. Pharmacol. Toxicol. 30 (1990) 219-249
42. Garro A.J., Seitz H.K., and Lieber C.S. Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption. Cancer Res. 41 (1981) 120-124
43. Geesin J.C., Hendricks L.J., Falkenstein P.A., Gordon J.S., and Berg R.A. Regulation of collagen synthesis by ascorbic acid: Characterization of the role of ascorbate-stimulated lipid peroxidation. Arch. Biochem. Biophys 290 (1991) 127-132
44. Gerster H. Potential role of β-carotene in the prevention of cardiovascular disease. Int. J. Vit. N Res. 61 (1991) 277-291
45. Greenway C.V., and Lautt W.W. Acute and chronic ethanol on hepatic oxygen ethanol and lactate metabolism in cats. Am. J. Physiol. 258 (1990) 411-418
46. Halevy O., and Sklan D. Inhibition of arachidonic acid oxidation by beta-carotene, retinol and alpha-tocopherol. Biochim. Biophys. Acta 918 (1987) 304-307
47. Halliwell B., and Gutteridge J.M.C. "Free Radicals in Biology and Medicine". 2nd Ed. (1989), Clarendon Press, Oxford 188-214
48. Handler J.A., and Thurman R.G. Fatty acid-dependent ethanol metabolism. Biochem. Biophys. Res. Commun. 133 (1985) 44-51
49. Handler J.A., and Thurman R.G. Redox interactions between catalase and alcohol dehydrogenase pathways of ethanol metabolism in the perfused rat liver. J. Biol. Chem. 265 (1990) 1510-1515
50. Hasumura Y., Teschke R., and Lieber C.S. Hepatic microsomal ethanol oxidizing system (MEOS): Dissociation from reduced nicotinamide adenine dinucleotide phosphate-oxidase and possible role of form 1 of cytochrome P-450. J. Pharmacol. Exp. Ther. 194 (1975) 469-474
51. Hetu C., Dumont A., and Joly J.G. Effect of chronic ethanol administration on bromobenzene liver toxicity in the rat. Toxicol. Appl. Pharmacol. 67 (1983) 166-167
52. Hetu C., and Joly J.G. Differences in the duration of the enhancement of liver mixed-function oxidase activities in ethanol-fed rats after withdrawal. Biochem. Pharmacol. 34 (1985) 1211-1216
53. Hirano T., Kaplowitz N., Tsukamoto H., Kamimura S., and Fernandez-Checa J.C. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 6 (1992) 1423-1427
54. 32P-polyene-phosphatidylcholin in die leber von ratten und seine ausscheidung durch die galle. Z. Naturforsch. 26 (1971) 1151-1158
55. Horowitz J.H., Rypins E.B., Henderson J.M., Heymsfield S.B., Moffit S.D., Bain R.P., Chawla R.K., Bleier J.C., and Rudman D. Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology 81 (1981) 668-675
56. Inatomi N., Kato S., Ito D., and Lieber C.S. Role of peroxisomal fatty acid beta-oxidation in ethanol metabolism. Biochem. Biophys. Res. Commun. 163 (1989) 418-423
57. Ingelman-Sundberg M., and Johansson I. Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450. J. Biol. Chem. 259 (1984) 6447-6458
58. Iseri O.A., Gottlieb L.S., and Lieber C.S. The ultrastructure of ethanol-induced fatty liver. Fed. Proc. 23 (1964) 579
59. Iseri O.A., Lieber C.S., and Gottlieb L.S. The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am. J. Pathol. 48 (1966) 535-555
60. Israel Y., Kalant H., Orrego H., Khanna J.M., Videla I., and Phillips J.M. Experimental alcohol-induced hepatic necrosis: Suppression by propylthiouracil. Proc. Natl. Acad. Sci. U.S.A. 72 (1975) 1137-1141
61. Jauhonen P., Baraona E., Miyakawa H., and Lieber C.S. Mechanism for selective perivenular hepatotoxicity of ethanol. Alcoholism Clin. Exp. Res. 6 (1982) 350-357
62. Jenkins M.Y., Sheikh M.N., Mitchell G.V., Grundel E., Blakely S.R., and Carter C.J. Dietary carotenoids influenced biochemical but not morphological changes in adult male rats fed a choline-deficient diet. Nutr. Cancer 19 (1993) 55-65
63. Johansson I.J., Ekstrom G., Scholte B., Puzycki D., Jornvall H., and Ingelman-Sundberg M. Ethanol-fasting, and acetone-inducible cytochromes P-450 in rat liver: Regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry 27 (1988) 1925-1934
64. Kaikaus R.M., Chan W.K., Lysenko N., Ortiz P., Montellano D., and Bass N.M. Induction of liver fatty acid binding protein (1-FABP) and peroxisomal fatty acid β- oxidation by peroxisome proliferators (PP) is dependent on cytochrome p-450 activity. Hepatology 12 (1990) A248
65. Kato S., Alderman J., and Lieber C.S. Respective roles of microsomal ethanol oxidizing system (MEOS) and catalase in ethanol metabolism by deermice lacking alcohol dehydrogenase. Arch. Biochem. Biophys. 254 (1987) 586-591
66. Kato S., Alderman J., and Lieber C.S. Ethanol metabolism in alcohol dehydrogenase deficient deermice is mediated by the microsomal ethanol oxidizing system, not by catalase. Alcohol Alcoholism 1 Suppl (1987) 231-234
67. Kato S., Kawase T., Alderman J., Inatomi N., and Lieber C.S. Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats. Gastroenterology 98 (1990) 203-210
68. Kawase T., Kato S., and Lieber C.S. Lipid peroxidation and antioxidant defense systems in rat liver after chronic ethanol feeding. Hepatology 10 (1989) 815-821
69. Keilin D., and Hartree E.F. Properties of catalase: Catalysis of coupled oxidation of alcohols. Biochem J 39 (1945) 293-301
70. Kessler B.J., Lieber J.B., Bronfin G.J., and Sass M. The hepatic blood flow and splanchnic oxygen consumption in alcohol fatty liver. J. Clin. Invest. 33 (1954) 1338-1345
71. Khani S.C., Zaphiropoulos P.G., Fujita V.S., Porter T.D., Koop D.R., and Coon M.J. cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a; (P450ALC). Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 638-642
72. Kim S.G., and Novak R.F. Induction of rat hepatic P450IIE1 (CYP 2E1) by pyridine: Evidence for a role of protein synthesis in the absence of transcriptional activation. Biochem. Biophys. Res. Commun. 166 (1990) 1072-1079
73. Kim S.G., Shehin S.E., States J.C., and Novak R.F. Evidence for increased translational efficiency in the induction of P450IIE1 by solvents: Analysis of P450IIE1 mRNA polyribosomal distribution. Biochem. Biophys. Res. Commun. 172 (1990) 767-774
74. Kim-Jun H. Inhibitory effects of α- and β-carotene on croton oil-induced or enzymatic lipid peroxidation and hydroperoxide production in mouse skin epidermis. Int. J. Biochem. 25 (1993) 911-915
75. Koivisto T., Mishin V.M., Mak K.M., Cohen P.A., and Lieber C.S. Induction of cytochrome P-4502E1 by ethanol in rat Kupffer cells. Alcoholism Clin. Exp. Res. 20 (1996) 207-212
76. Koop D.R., and Casazza J.P. Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. J. Biol. Chem. 260 (1985) 13607-13612
77. Koop D.R., Morgan E.T., Tarr G.E., and Coon M.I. PO!O!ication and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J. Biol. Chem. 257 (1982) 8472-8780
78. Koop D.R., and Tierney D.J. Multiple mechanism in the regulation of ethanol-inducible cytochrome P450IIE1. BioEssays 12 (1990) 429-435
79. Krinsky N.I. Antioxidant functions of carotenoids. Free Rad. Biol. Med. 7 (1989) 617-635
80. Krinsky N.I., and Deneke S.M. Interaction of oxygen and oxy-radicals with carotenoids. J. Natl. Cancer Inst. 69 (1982) 205-210
81. Kubota S., Lasker J.M., and Lieber C.S. Molecular regulation of ethanol inducible cytochrome P450-IIE1 in hamsters. Biochem. Biophys. Res. Commun. 150 (1988) 304-310
82. Kunert K.J., and Tappel A.L. The effect of vitamin C on in vitro lipid peroxidation in guinea pigs as measured by pentane and ethanol production. Lipids 18 (1983) 271-274
83. Lane B.P., and Lieber C.S. Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets. Am. J. Pathol. 49 (1966) 593-603
84. Lane B.P., and Lieber C.S. Effects of butylated hydroxytoluene on the ultrastructure of rat hepatocytes. Lab. Invest. 16 (1967) 341-348
85. Lasker J.M., Raucy J., Kubota S., Bloswick B.P., Black M., and Lieber C.S. Purification and characterization of human liver cytochrome P-450-ALC. Biochem. Bio-phys. Res. Commun. 148 (1987) 232-238
86. Lauterburg B.H., Liang D., Schwarzenbach F.A., and Breen K.J. Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis. Hepatology 17 (1993) 418-422
87. Lefevre A., Adler H., and Lieber C.S. Effect of ethanol on ketone metabolism. J. Clin. Invest. 49 (1970) 1775-1782
88. Lekim D., and Betzing H. The incorporation of essential phospholipids into the organs of intact and galactosamine intoxicated rats. Drug Res. 24 (1974) 1217-1221
89. Lekim D., and Graf E. Tierexperimentelle studien zur pharmakokinetik der 'essentiellen' phospholipide; (EPL). Arzneimittelforschung 26 (1976) 1772-1782
90. Lekim D., Betzing H., and Stoffel W. Incorporation of complete phospholipid molecules in cellular membranes of rat liver after uptake from blood serum. Z. Physiol. Chem. 353S (1972) 929-946
91. Leo M.A., Arai M., Sato M., and Lieber C.S. Hepatotoxicity of vitamin A and ethanol in the rat. Gastroenterology 82 (1982) 194-205
92. +-dependent retinol dehydrogenase in liver microsomes. Arch. Biochem. Biophys. 259 (1987) 241-249
93. Leo M.A., Kim C.I., Lowe N., and Lieber C.S. Interaction of ethanol with β-carotene: Delayed blood clearance and enhanced hepatotoxicity. Hepatology 15 (1992) 883-891
94. Leo M.A., and Lieber C.S. Hepatic fibrosis after long term administration of ethanol and moderate vitamin A supplementation in the rat. Hepatology 2 (1983) 1-11
95. Leo M.A., and Lieber C.S. New pathway for retinol metabolism in liver microsomes. J. Biochem. 260 (1985) 5228-5231
96. Leo M.A., and Lieber C.S. Hypervitaminosis A: A liver lover's lament. Hepatology 8 (1988) 412-417
97. Leo M.A., Lowe N., and Lieber C.S. Interaction of drugs and retinol. Biochem. Pharmacol. 35 (1986) 3949-3953
98. Leo M.A., Rosman A., and Lieber C.S. Differential depletion of carotenoids and tocopherol in liver diseases. Hepatology 17 (1993) 977-986
99. Leo M.A., Sato M., and Lieber C.S. Effect of hepatic vitamin A depletion on the liver in men and rats. Gastroenterology 84 (1983) 562-572
100. Li J.-J., Kim C.-I., Leo M.A., Mak K.M., Rojkind M., and Lieber C.S. Polyunsaturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes. Hepatology 15 (1992) 373-381
101. Lieber C.S. The influence of alcohol on nutritional status. Nutr. Rev. 46 (1988) 241-245
102. Lieber C.S. Hepatic, metabolic and toxic effects of ethanol: 1991 update. Alcoholism Clin. Exp. Res. 15 (1991) 573-592
103. Lieber C.S. "Medical and Nutritional Complications of Alcoholism: Mechanisms and Management" (1992), Plenum Press, New York 579
104. Lieber C.S. Liver fibrosis: from pathogenesis to treatment. In: De Pretis D.F. (Ed). "Advances in Hepatobiliary and Pancreatic Diseases" (1995), Kluwer Academic Press, Lancaster, UK 62-81
105. Lieber C.S. Prevention and therapy with S-adenosyl-L-methionine and polyenylphos-phatidyl-choline. In: Arroyo V., Bosch J., and Rodes J. (Eds). "Treatments in Hepatology" (1995), Masson, S. A., Barcelona 299-311
106. Lieber C.S., Baraona E., Hernandez-Munoz R., Kubota S., Sato N., Kawano S., Matsumura T., and Inatomi N. Impaired oxygen utilization: A new mechanism for the hepatotoxicity of ethanol in sub-human primates. J. Clin. Invest. 83 (1989) 1682-1690
107. Lieber C.S., Casini A., Decarli L.M., Kim C., Lowe N., Sasaki R., and Leo M.A. S-Adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology 11 (1990) 165-172
108. Lieber C.S., and Decarli L.M. Ethanol oxidation by hepatic microsomes: Adaptive increase after ethanol feeding. Science 162 (1968) 917-918
109. Lieber C.S., and Decarli L.M. Hepatic microsomal ethanol oxidizing system: In vitro characteristics and adaptive properties in vivo. J. Biol. Chem. 245 (1970) 2505-2512
110. Lieber C.S., and Decarli L.M. Reduced nicotinamide-adenine dinucleotide phosphate oxidase: Activity enhanced by ethanol consumption. Science 170 (1970) 78-80
111. Lieber C.S., Garro A., Leo M.A., Mak K.M., and Worner T.M. Alcohol and cancer. Hepatology 6 (1986) 1005-1019
112. Lieber C.S., Jones D.P., Losowsky M.S., and Davidson C.S. Interrelation of uric acid and ethanol metabolism in man. J. Clin. Invest. 41 (1962) 1863-1870
113. Lieber C.S., Lasker J.M., Decarli L.M., Saeli J., and Wojtowicz T. Role of acetone, dietary fat, and total energy intake in the induction of the hepatic microsomal ethanol oxidizing system. J. Pharmacol. Exp. Ther. 247 (1988) 791-795
114. Lieber C.S., Leo M.A., Aleynik S.I., Aleynik M.A., and Decarli L.M. Polyenylphos-phatidylcholine (PPC) decreases oxidant stress and protects against alcohol-induced liver injury in the baboon. Hepatology 22 (1995) 225A
115. Lieber C.S., Li J.I., Robins S., Decarli L.M., Mak K.M., and Leo M.A. Dietary dilinoleoylphosphatidyl-choline (DLPC) is incorporated into liver phospholipids, protects against alcoholic cirrhosis, enhances collagenase activity and prevents acetaldehyde-induced collagen accumulation in cultured lipocytes. Hepatology 16 (1992) 87A [Abstract]
116. Lieber C.S., Robins S., Li J., Decarli L.M., Mak K.M., Fasulo J.M., and Leo M.A. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 106 (1994) 152-159
117. Lieber C.S., Robins S.J., and Leo M.A. Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine. Alcoholism Clin. Exp. Res. 18 (1994) 592-595
118. Lomnitski L., Bar-Natan R., Sklan D., and Grossman S. The interaction between β-carotene and lipoxygenase in plant and animal systems. Biochim. Biophys. Acta 1167 (1993) 331-338
119. Machlin L.J., and Bendich A. Free radical tissue damage: Protective role of antioxidant nutrients. FASEB J. 1 (1987) 441-445
120. Mccay P.B. Vitamin E interaction with free radical and ascorbate. Annu. Rev. Nutr. 5 (1985) 323-340
121. Meldolesi J. On the significance of the hypertrophy of the smooth endoplasmic reticulum in liver cells after administration of drugs. Biochem. Pharmcol. 16 (1967) 125-131
122. Misra P.S., Lefevre A., Ishii H., Rubin E., and Lieber C.S. Increase of ethanol meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats. Am. J. Med. 51 (1971) 346-351
123. Miwa G.T., Levin W., Thomas P.E., and Lu A.Y.H. The direct oxidation of ethanol by catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-450. Arch. Biochem. Biophys. 187 (1978) 464-475
124. Mobarhan S., Bowen P., Andersen B., Evans M., Stacewicz-Sapuntzakis M., Sugerman S., Simms P., Lucchesi D., and Friedman H. Effects of β-carotene repletion of β- carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men. Nutr. Cancer 14 (1990) 195-206
125. Morgan E.T., Koop D.R., and Coon M.J. Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. J. Biol. Chem. 257 (1982) 13951-13957
126. Morgan E.T., Koop D.R., and Coon M.J. Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen. Biochem. Biophys. Res. Commun. 112 (1983) 8-13
127. Morton S., and Mitchell M.C. Effects of chronic ethanol feeding on glutathione turnover in the rat. Biochem. Pharmacol. 34 (1985) 1559-1563
128. Müller A., and Sies H. Role of alcohol dehydrogenase activity and of acetaldehyde in ethanol-induced ethane and pentane production by isolated perfused rat liver. Biochem. J. 206 (1982) 153-156
129. Müller A., and Sies H. Inhibition of ethanol- and aldehyde-induced release of ethane from isolated perfused rat liver by pargyline and disulfiram. Pharmacol. Biochem. Behav. 18 (1983) 429-432
130. Nakajima T., Okino T., and Sato A. Kinetic studies on benzene metabolism in rat liver: possible presence of three forms of benzene metabolizing enzymes in the liver. Biochem. Pharmacol. 36 (1987) 2799-2804
131. Navder K.P., Baraona E., and Lieber C.S. Effects of polyenylphosphatidylcholine (PPC) on alcohol-induced fatty liver and hyperlipemia in rats. Gastroenterology 110 (1996) 1275
132. Niki E. Interaction of ascorbate and α-tocopherol. Ann. N.Y. Acad. Sci. 493 (1987) 186-199
133. Nilsson A.K.E. Intestinal absorption of lecithin and lysolecithin by lymph fistula rats. Biochim. Biophys. Acta 152 (1968) 379-390
134. Nordmann R., Ribière C., and Rouach H. Implication of free radical mechanisms in ethanol-induced cellular injury. Free Rad. Biol. Med. 12 (1992) 219-240
135. Ohnishi K., and Lieber C.S. Reconstitution of the microsomal ethanol-oxidizing system: Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption. J. Biol. Chem. 252 (1977) 7124-7131
136. Oshino N., Chance B., Sies H., and Bücher T. The role of H2O, generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors. Arch. Biochem. Biophys. 154 (1973) 117-131
137. Palozza P., and Krinsky N.I. The inhibition of radical-initiated peroxidation of microsomal lipids by both α-tocopherol and β-carotene. Free Rad. Biol. Med. 11 (1991) 407-414
138. Parfitt V.J., Desomeaux K., Bolton C.H., and Hartog M. Effects of high monoun-saturated and polyunsaturated fat diets on plasma lipoproteins and lipid peroxidation in Type 2 diabetes mellitus. Diab. Med. 11 (1994) 85-91
139. Parthasarathy S., Subbaiah P.V., and Ganguly J. The mechanism of intestinal absorption of phosphatidylcholine in rats. Biochem. J. 140 (1974) 503-508
140. Patton G.M., Clark S.B., Fasulo J.M., and Robins S.I. Utilization of individual lecithins in intestinal lipoprotein formation in the rat. J. Clin. Invest. 73 (1984) 231-240
141. Porter T.D., Khani S.C., and Coon M.J. Induction and tissue-specific expression of rabbit cytochrome P450IIE1 and IIE2 genes. Mol. Pharmacol. 36 (1989) 61-65
142. Reinke L., Lai E.K., Dubose C.M., Mccay P.B., and Janzen E.G. Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: Correlation with radical formation in vitro. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 8223-8227
143. Reinke L.A., Kotake Y., Mccay P.B., and Janzen E.G. Spin trapping studies of hepatic free radicals formed following the acute administration of ethanol to rats: In vivo detection of I-hydroxyethyl radicals with PBN. Free Rad. Biol. Med. 11 (1991) 31-39
144. Rodgers J.B., O'Brien R.J., and Balint J.A. The absorption and subsequent utilization of lecithin by the rat jejunum. Am. J. Digest. Dis. 20 (1975) 208-211
145. Ronis M.J., Huang J., Crouch J., Mercado C., Irby D., Valentine Cr., Lumpkin C.K., Ingelman-Sundberg M., and Badger T.M. Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentration in rats. J. Pharmacol. Exp. Ther. 264 (1993) 944-950
146. Sato C., Matsuda Y., and Lieber C.S. Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat. Gastroenterology 80 (1981) 140-148
147. Sato M., and Lieber C.S. Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats. J. Nutr. 111 (1981) 2015-2023
148. Sato N., Kamada T., Kawano S., Hayashin N., Kishida Y., Meren H., Yoshihara H., and Abe H. Effect of acute and chronic ethanol consumption on hepatic tissue oxygen tension in rats. Pharmacol. Biochem. Beh. 18 (1983) 443-447
149. Seitz H.K., and Poschl G. Antioxidant drugs and colchicine in the treatment of alcoholic liver disease. In: Arroyo V., Bosch J., and Rodes J. (Eds). "Treatments in Hepatology" (1995), Masson, S. A., Barcelona 271-276
150. Seitz H.K., Czygan P., Waldherr K., Veith S., and Kommerell B. Ethanol and intestinal carcinogenesis in the rat. Alcohol 2 (1985) 491-494
151. Seitz H.K., Garro A.J., and Lieber C.S. Enhanced pulmonary and intestinal activation of procarcinogens and mutagens after chronic ethanol consumption in the rat. Eur. J. Clin. Invest. 11 (1981) 33-38
152. Shaw S., Heller E.A., Friedman H.S., Baraona E., and Lieber C.S. Increased hepatic oxygenation following ethanol administration in baboon. Proc. Soc. Exp. Biol. Med. 156 (1977) 509-513
153. Shaw S., Jayatilleke E., Ross W.A., Gordon E.R., and Lieber C.S. Ethanol induced lipid peroxidation: Potentiation by long-term alcohol feeding and attenuation by methionine. J. Lab. Clin. Med. 98 (1981) 4171-4425
154. Shaw S., and Lieber C.S. Increased hepatic production of alpha-amino-n-butyric acid after chronic alcohol consumption in rats and baboons. Gastroenterology 78 (1980) 108-113
155. Shaw S., Rubin K.P., and Lieber C.S. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease: Evidence of lipid peroxidation. Digest Dis. Sci. 28 (1983) 585-589
156. Shimizu M., Lasker J.M., Tsutsumi M., and Lieber C.S. Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract. Gastroenterology 99 (1990) 1044-1053
157. Siegers C.P., Heidbuchel K., and Younes M. Influence of alcohol, dithiocarb and ( + )-catechin on the hepatotoxicity and metabolism of vinylidene chloride in rats. J. Appl. Toxicol. 3 (1983) 90-95
158. Sies H., and Chance B. The steady state level of catalase compound I in isolated hemoglobin-free perfused rat liver. FEBS Lett. 11 (1970) 172-176
159. Smith T., Demaster E.G., Fume J.K., Springfield J., and Levitt M.D. First-pass gastric mucosal metabolism of ethanol is negligible in the rat. J. Clin. Invest. 89 (1992) 1801-1806
160. Song B.J., Gelboin H.V., Park S.S., Yang C.S., and Gonzalez F.I. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450j: Transcriptional and post-transcriptional regulation of the rat enzyme. J. Biol. Chem. 261 (1986) 16689-16697
161. Song B.J., Matsunaga T., Hardwick J., Park S.S., Veech R.I., Yang C.S., Gelboin H.V., and Gonzalez F.J. Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat. Mol. Endocrinol. 1 (1987) 542-547
162. Song B.J., Veech R.I., Park S.S., Gelboin H.V., and Gonzalez F.J. Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. J. Biol. Chem. 264 (1989) 3568-3572
163. Sosenko I.R.S., Innis S.M., and Frank L. Polyunsaturated fatty acids and protection of newborn rats from oxygen toxicity. J. Pediatr. 112 (1988) 630-637
164. Sosenko I.R.S., Innis S.M., and Frank I. Menhaden fish oil, n-3 polyunsaturated fatty acids and protection of newborn rats from oxygen toxicity. Pediatr. Res. 25 (1989) 399-404
165. Sosenko I.R.S., Innis S.M., and Frank L. Intralipid increases lung polyunsaturated fatty acids and protects newborn rats from oxygen toxicity. Pediatr. Res. 30 (1991) 413-417
166. Speisky H., Macdonald A., Giles G., Orrego H., and Israel Y. Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Biochm. J. 225 (1985) 565-572
167. Spitz D.R., Kinter M.T., Kehrer J.P., and Roberts R.J. The effect of monounsaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells. Pediatr. Res. 32 (1992) 366-372
168. Stein S.W., Lieber C.S., Cherrick G.R., Leevy C.M., and Ablemann W.H. The effect of ethanol upon systemic hepatic blood flow in man. Am. J. Clin. Nutr. 13 (1963) 68-74
169. Takagi T., Ishii H., Takahashi H., Kato S., Okuno F., Ebihara Y., Yamauchi H., Nagata Y., Tashiro M., and Tsuchiya M. Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: An animal model of halothane hepatitis. Pharmacol. Biochem. Behav. 18 Suppl. 1 (1983) 461-465
170. Takagi T., Alderman J., Geller J., and Lieber C.S. Assessment of the role of non-ADH ethanol oxidation in vivo and in hepatocytes from deer mice. Biochem. Pharmacol. 35 (1986) 3601-3606
171. Takahashi T., Lasker J.M., Roman A.S., and Lieber C.S. Induction of P450E1 in human liver by ethanol is due to a corresponding increase in encoding mRNA. Hepatology 17 (1993) 236-245
172. Teschke R., Hasumura Y., Joly J.G., Ishii H., and Lieber C.S. Microsomal ethanol-oxidizing system (MEOS): Purification and properties of a rat liver system free of catalase and alcohol dehydrogenase. Biochem. Biophys. Res. Commun. 49 (1972) 1187-1193
173. Teschke R., Hasumura Y., and Lieber C.S. Hepatic microsomal alcohol oxidizing system: Solubilization, isolation and characterization. Arch. Biochem. Biophys. 163 (1974) 404-415
174. Teschke R., Matsuzaki S., Ohnishi K., Decarli L.M., and Lieber C.S. Microsomal ethanol oxidizing system (MEOS): Current status of its characterization and its role. Alcoholism Clin. Exp. Res. 1 (1977) 7-15
175. Thurman R.G., and Brentzel H.J. The role of alcohol dehydrogenase in microsomal ethanol oxidation and the adaptive increase in ethanol metabolism due to chronic treatment with ethanol. Alcoholism Clin. Exp. Res. 1 (1977) 33-38
176. Tsukamoto H. Oxidative stress, antioxidants, and alcoholic liver fibrogenesis. Alcohol 10 (1993) 465-467
177. Tsutsumi M., Lasker J.M., Shimizu M., Roman A.S., and Lieber C.S. The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology 10 (1989) 437-446
178. Tsutsumi M., Lasker J.M., Takahashi T., and Lieber C.S. In vivo induction of hepatic P4502E1 by ethanol: Role of increased enzyme synthesis. Arch. Biochem. Biophys. 304 (1993) 209-218
179. Tsutsumi R., Leo M.A., Kim C., Tsutsumi M., Lasker J.M., Lowe N., and Lieber C.S. Interaction of ethanol with enflurane metabolism and toxicity: Role of P450IIE1. Alcoholism Clin. Exp. Res. 14 (1990) 174-179
180. Valenzuela A., Fernandez V., and Videla L.A. Hepatic and biliary levels of flutathione and lipid peroxides following iron overload in the rat: Effect of simultaneous ethanol administration. Toxicol. Appl. Pharmacol. 70 (1983) 87-95
181. Vendemiale G., Altomare E., Trizzio T., Le Grazzie C., Dipadova C., Salerno T., Carrieri V., and Albano O. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand. J. Gastroenterol. 24 (1989) 407-415
182. Von Herbay A., De Groot H., Hegi U., Stremmel W., Strohmeyer G., and Sies H. Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and Wilson's disease. J Hepatol. 20 (1994) 41-46
183. Williamson J.R., Scholz R., Browning E.T., Thurman R.G., and Fukami M.H. Metabolic effects of ethanol in perfused rat liver. J. Biol. Chem. 25 (1969) 5044-5054
184. Yamada S., Mak K.M., and Lieber C.S. Chronic ethanol consumption alters rat liver plasma membranes and potentiates release of alkaline phosphatase. Gastroenterology 88 (1985) 1799-1806
185. Yang C.S., Tu Y.Y., Koop D.R., and Coon M.J. Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes. Cancer Res. 45 (1985) 1140-1145
186. Zhang H., Loney L.A., and Potter B.J. Effect of chronic alcohol feeding on hepatic iron status and ferritin uptake by rat hepatocytes. Alcoholism Clin. Exp. Res. 17 (1993) 394-400
187. Zierenberg O., and Grundy S.M. Intestinal absorption of polyenylphosphatidylcholine in man. J. Lipid Res. 23 (1982) 1136-1142