Cyp2e1 is not involved in early alcohol-induced liver injury

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 277, Issue 6 40-6, 1999, Pages

  Kono, Hiroshi ^a   Bradford, Blair U ^a   Yin, Ming ^a   Sulik, Kathleen K ^b   Koop, Dennis R ^d   Peters, Jeffrey M ^e   Gonzalez, Frank J ^e   McDonald, Tasha ^d   Dikalova, Anna ^c   Kadiiska, Maria B ^c   Mason, Ronald P ^c   Thurman, Ronald G ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CYP2E1 knockout mouse; Intragastric feeding

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; REACTIVE OXYGEN METABOLITE;

ALCOHOL LIVER CIRRHOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME REGULATION; FEMALE; LIVER CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033370831     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.277.6.g1259     Document Type: Article

References (35)

1. Adachi, Y., B. U. Bradford, W. Gao, H. K. Bojes, and R. G. Thurman. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 20: 453-460, 1994.
2. Adachi, Y., L. E. Moore, B. U. Bradford, W. Gao, and R. G. Thurman. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108: 218-224, 1995.
3. Albano, E., P. Clot, M. Morimoto, A. Tomasi, M. Ingelman-Sundberg, and S. W. French. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology 23: 155-163, 1996.
4. Arteel, G. E., Y. Iimuro, M. Yin, J. A. Raleigh, and R. G. Thurman. Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo. Hepatology 25: 920-926, 1997.
5. Badger, T. M., J. Crouch, D. Irby, and M. Shahare. Episodic excretion of ethanol during chronic intragastric ethanol infusion in the male rat: continuous vs. cyclic ethanol and nutrient infusions. J. Pharmacol. Exp. Ther. 264: 938-943, 1993.
6. Badger, T. M., M. J. J. Ronis, M. Ingelman-Sundberg, and R. Hakkak. Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic ethanol infusions. Eur. J. Biochem. 230: 914-919, 1995.
7. Bergmeyer, H. U. Methods of Enzymatic Analysis. New York: Academic, 1988.
8. Brunner, L. J., W. M. Bennett, and D. R. Koop. Cyclosporine suppressess rat hepatic cytochrome P450 in a time-dependent manner. Kidney Int. 54: 216-223, 1998.
9. Duling, D. R. Simulation on multiple isotropic spin-trap EPR spectra. J. Magn. Reson. 104: 105-110, 1994.
10. French, S. W. Nutrition in the pathogenesis of alcoholic liver disease. Alcohol Alcohol. 28: 97-109, 1993.
11. French, S. W., K. Wong, L. Jui, E. Albano, A. L. Hagbjork, and M. Ingelman-Sundberg. Effect of ethanol on cytochrome-P450-2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis. Exp. Mol. Pathol. 58: 61-75, 1993.
12. Glassman, E. B., G. A. McLaughlin, D. T. Forman, M. R. Felder, and R. G. Thurman. Role of alcohol dehydrogenase in the swift increase in alcohol metabolism (SIAM): studies with deer mice deficient in alcohol dehydrogenase. Biochem. Pharmacol. 34: 3523-3526, 1989.
13. Iimuro, Y., M. v. Frankenberg, G. E. Arteel, B. U. Bradford, C. A. Wall, and R. G. Thurman. Female rats exhibit greater susceptibility to early alcohol-induced injury than males. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G1186-G1194, 1997.
14. Ioannides, C. Cytochrome P450: Metabolic and Toxicological Aspects. New York, CRC, 1996.
15. Ingelman-Sundberg, M., and I. Johansson. Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450. J. Biol. Chem. 259: 6447-6458, 1984.
16. Kennedy, S. W., and S. P. Jones. Simulataneous measurement of cytochrome P4501A catalytic cativity and total protein concentration with a fluorescence plate reader. Anal. Biochem. 222: 217-223, 1994.
17. Knecht, K. T., Y. Adachi, B. U. Bradford, Y. Iimuro, M. Kadiiska, X. Qun-hui, and R. G. Thurman. Free radical adducts in the bile of rats treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells. Mol. Pharmacol. 47: 1028-1034, 1995.
18. Kono, H., Yin, M., Bradford, B. U., Gonzalez, F. J., and Thurman, R. G. Development of a new enteral mouse model using knockout technology to study alcohol-induced liver injury: is CYP2E1 involved (Abstract). Hepatology 28: 330A, 1998.
19. Koop, D. R., B. Klopfenstein, Y. Iimuro, and R. G. Thurman. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol. Pharmacol. 51: 944-950, 1997.
20. Lee, S. S. T., J. T. M. Busters, T. Pineau, P. Fernandez-Salguero, and F. J. Gonzalez. Role of CYP2E1 in the hepatotoxicity of acetamonophen. J. Biol. Chem. 271: 12063-12067, 1996.
21. Lubet, R. A., J. L. Syi, J. O. Nelson, and R. W. Nims. Induction of hepatic cytochrome P-450 mediated alkkoxyresorfin O-dealkylase activities in different species by prototype P-450 inducer. Chem. Biol. Interact. 75: 325-339, 1990.
22. Lytton, S. D., A. Heland, Z.-Q. Zhang-Gouillon, K. Stokkeland, R. Bordone, S. Arico, E. Albano, S. W. French, and M. Ingelman-Sundberg. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Mol. Pharmacol. 55: 223-233, 1999.
23. Morimoto, M., M. A. Zern, A. L. Hagbjork, M. Ingelman-Sundberg, and S. W. French. Fish oil, alcohol, and liver pathology: role of cytochrome P4502E1. Proc. Soc. Exp. Biol. Med. 207: 197-205, 1994.
24. Nanji, A. A., U. Khettry, and S. M. H. Sadrzadeh. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease. Proc. Soc. Exp. Biol. Med. 205: 243-247, 1994.
25. Nanji, A. A., C. L. Mendenhall, and S. W. French. Beef fat prevents alcoholic liver disease in the rat. Alcohol. Clin. Exp. Res. 13: 15-19, 1989.
26. Ronis, M. J. J., J. Huang, J. Crouch, C. Mercado, D. Irby, C. R. Valentine, C. K. Lumpkin, M. Ingelman-Sundberg, and T. M. Badger. Cytochrome P450 CYP2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats. J. Pharmacol. Exp. Ther. 264: 944-950, 1993.
27. Schnier, G. G., C. L. Laethem, and D. R. Koop. Identification and induction of cytochromes P450, P450IIE1 and P450IA1 in rabbit bone marrow. J. Pharmacol. Exp. Ther. 251: 790-796, 1989.
28. Smithies, O. Animal models of human genetic diseases. Trends Genet. 9: 112-116, 1993.
29. Thompson, J. A., and R. C. Reitz. Effects of ethanol ingestion and dietary fat levels on mitochondrial lipids in male and female rats. Lipids 13: 540-550, 1978.
30. Tsukamoto, H., S. W. French, R. D. Reidelberger, and C. Largman. Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats. Alcohol. Clin. Exp. Res. 9: 31-37, 1985.
31. Tsukamoto, H., K. Gaal, and S. W. French. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12: 599-608, 1990.
32. Tsukamoto, H., R. D. Reiderberger, S. W. French, and C. Largman. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am. J. Physiol. 247 (Regulatory Integrative Comp. Physiol. 16): R595-R599, 1984.
33. Wong, F., W. Chan, and S. Lee. Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol. Appl. Pharmacol. 153: 109-118, 1998.
34. Yin, M., Wheeler, M. D., Kono, H., Bradford, B. U., Gallucci, R. M., Luster, M. I., and Thurman, R. G. Essential role of tumor necrosis factor α in alcohol-induced liver injury. Gastroenterology 117: 942-952, 1999.
35. Zhang-Gouillon, Z. Q., Q.-X. Yuan, B. Hu, N. Marceau, B. A. French, K. Gaal, Y. Nagao, Y.-J. Y. Wan, and S. W. French. Mallory body formation by ethanol feeding in drug-primed mice. Hepatology 27: 116-122, 1998.