Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver

Journal of Hepatology

Volumn 32, Issue 6, 2000, Pages 900-910

  Järveläinen, Harri A ^d   Fang, Che ^a   Ingelman Sundberg, Magnus ^a   Lukkari, Tuomo A ^d   Sippel, Helmuth ^b   Lindros, Kai O ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

^c Kai O Lindros   (Finland)

^d NONE

Author keywords

Cytokine activation; Ethanol inducible CYP2E1; Gadolinium chloride; Inflammation; Kupffer cells; Steatosis

Indexed keywords

DIMETHYLNITROSAMINE DEMETHYLASE; GADOLINIUM CHLORIDE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CARBOHYDRATE INTAKE; CELL LYSATE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; INFLAMMATION; KUPFFER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STEATOSIS;

EID: 0342369372     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)80094-X     Document Type: Article

References (65)

1. Simpson KJ, Lukacs NW, Colletti L, Strieter RM, Kunkel SL. Cytokines and the liver. J Hepatol. 27:1997;1120-1132.
2. Bode C, Kugler V, Bode JC. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol. 4:1987;8-14.
3. Nanji AA, Khettry U, Sadrzadeh SMH. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease. Proc Soc Exp Biol Med. 205:1994;243-247.
4. Järveläinen HA, Fang C, Ingelman-Sundberg M, Lindros KO. Effect of chronic co-administration of endotoxin and ethanol on rat liver pathology and pro- and anti-inflammatory cytokines. Hepatology. 29:1999;1503-1510.
5. Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology. 108:1995;218-224.
6. Hansen J, Cherwitz DL, Allen JI. The role of tumor necrosis factor-α in acute endotoxin-induced hepatotoxicity in ethanol-fed rats. Hepatology. 20:1994;461-474.
7. Järveläinen HA, Oinonen T, Lindros KO. Alcohol-induced expression of the CD14 endotoxin receptor protein in rat Kupffer cells. Alcohol Clin Exp Res. 21:1997;1547-1551.
8. Morimoto M, Hagbjörk A-L, Nanji AA, Ingelman-Sundberg M, Lindros KO, Fu PC, et al. Role of cytochrome P4502E1 in alcohol liver disease pathogenesis. Alcohol. 10:1993;459-464.
9. Lindros KO. Alcoholic liver disease: pathobiological aspects. J Hepatol. (Suppl. 1):1995;7-15.
10. Morimoto M, Hagbjörk A-L, Wan Y-J Y, Fu PC, Clot P, Albano E, et al. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology. 21:1995;1610-1617.
11. Ekstöm G, Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P-450 IIE1). Biochem Pharmacol. 38:1989;1313-1319.
12. Ingelman-Sundberg M, Johansson I, Yin H, Terelius Y, Eliasson E, Clot P, et al. Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease. Alcohol. 10:1993;447-452.
13. Koop DR. Oxidative and reductive metabolism by cytochrome P-450 2E1. FASEB J. 6:1992;724-730.
14. Fang C, Lindros KO, Badger TM, Ronis MJ, Ingelman-Sundberg M. Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole. Hepatology. 27:1998;1304-1310.
15. Koop DR, Klopfenstein B, Iimuro Y, Thurman RG. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol Pharmacol. 51:1997;944-950.
16. Tsukamoto H, French SW, Benson N, Delgado G, Rao GA, Larkin EC, et al. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology. 5:1985;224-232.
17. Abril ER, Jones J, Jolley CS, Holubec H, Waite S, Sipes IG, et al. Binge-type alcohol intake recruits immune cells into rat liver and stimulates Kupffer cell release of cytokines and superoxide prior to any evidence of overt liver injury. Wisse E, Knook DL, Balabaud C. Cells of the Hepatic Sinusoid. 1997;303-305 Kupffer Cell Foundation.
18. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H, Brenner DA, et al. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology. 115:1998;443-451.
19. Abril ER, Earnest DL, Jolley CS, Chen G, Lantz RC. Enhanced Kupffer cell function characterizes the recovery period following binge type alcohol intake in rats. Wisse E, Knook DL, Balabaud C. Cells of the Hepatic Sinusoid. 1995;75-76 Kupffer Cell Foundation.
20. Zhong Z, Arteel GE, Connor HD, Schemmer P, Chou SC, Raleigh JA, et al. Binge drinking disturbs hepatic microcirculation after transplantation: prevention with free radical scavengers. J Pharmacol Exp Ther. 290:1999;611-620.
21. Lindros KO, Järveläinen HA. A new oral low-carbohydrate alcohol liquid diet producing liver lesions: a preliminary account. Alcohol Alcohol. 33:1998;347-353.
22. Laskin DL. Role of hepatic macrophages in inflammation and tissue injury. Vidal-Vanaclocha F. Functional Heterogeneity of Liver Tissue. 1997;161-176 R.G. Landes.
23. Saarinen J, Saarelainen R, Lindros KO. A rapid method to study heterogenous gene expression in liver by direct assay of messenger RNA from periportal and perivenous cell lysates. Hepatology. 17:1993;466-469.
24. Quistorff B, Grunnet N. Dual-digitonin perfusion. Concurrent sampling of periportal and perivenous cytosols of rat liver for determination of metabolites and enzyme activities. Biochem J. 243:1987;87-95.
25. Lindros KO, Penttilä KE. Digitonin-collagenase perfusion for efficient separation of periportal or perivenous hepatocytes. Biochem J. 228:1985;757-760.
26. Hu Y, Ingelman-Sundberg M, Lindros KO. Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation. Biochem Pharmacol. 50:1995;155-161.
27. Johansson I, Ekstrom G, Scholte B, Puzycki D, Jornvall H, Ingelman-Sundberg M. Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry. 27:1988;1925-1934.
28. Koop DR. The hydroxylation of p-nitrophenol by rabbit ethanol-inducible P450 isoenzyme 3a. Mol Pharmacol. 29:1986;399-404.
29. Habig WH, Papst MJ, Jakobyy WB. Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem. 249:1974;7130-7139.
30. Carmagnol F, Sinet PM, Jerome H. Selenium-dependent and non-selenium-dependent glutathione peroxidases in human tissue extracts. Biochim Biophys Acta. 759:1983;49-57.
31. Oinonen T, Lindros KO. Hormonal regulation of the zonated expression of cytochrome P450 3A in rat liver. Biochem J. 309:1995;55-61.
32. Katz ED, Dong MW. Rapid analysis and purification of polymerase chain reaction products by high-performance liquid chromatography. Biotechniques. 8:1990;546-555.
33. Lindros KO, Oinonen T, Johansson I, Ingelman-Sundberg M. Selective centrilobular expression of the aryl hydrocarbon receptor in rat liver. J Pharmacol Exp Ther. 280:1997;506-511.
34. Dijkstra CD, Dopp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology. 54:1985;589-599.
35. Hardonk MJ, Dikjhuis FWJ, Hulstaert CE, Koudstall J. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopoulation. J Leukoc Biol. 52:1992;296-302.
36. Kilty C, Doyle S, Hassett B, Manning F. Glutathione S-transferases as biomarkers of organ damage: applications of rodent and canine GST enzyme immunoassays. Chem Biol Interact. 24:1998;123-135.
37. Day CP, James OFW. Hepatic steatosis: innocent bystander or guilty party? Hepatology. 27:1998;1463-1466.
38. Bhagwandeen BS, Apte M, Manwarring L, Dickeson J. Endotoxin induced hepatic necrosis in rats on an alcohol diet. J Pathol. 152:1987;47-53.
39. Caraceni P, Ryu HS, Subbotin V, De Maria N, Colantoni A, Roberts L, et al. Rat hepatocytes isolated from alcohol-induced fatty liver have an increased sensitivity to anoxic injury. Hepatology. 25:1997;943-949.
40. Rai RM, Zhang JX, Clemens MG, Diehl AM. Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines. Shock. 6:1996;243-247.
41. 2 synthesis and septic mortality. Hepatology. 29:1999;756-765.
42. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ. Mathison JC: CD14, a receptor of lipopolysaccharide-binding protein. Science. 249:1990;1429-1433.
43. Tomita M, Yamamoto K, Kobashi H, Ohmoto M, Tsuji T. Immunohistochemical phenotyping of liver macrophages in normal and diseased human liver. Hepatology. 20:1994;317-325.
44. Matsuura K, Ishida T, Setoguchi M, Higuchi Y, Akizuki S, Yamamoto S. Upregulation of mouse CD14 expression in Kupffer cells by lipopolysaccharide. J Exp Med. 179:1994;1671-1676.
45. Su GL, Rahemtulla A, Thomas P, Klein RD, Wang SC, Nanji AA. CD14 and lipopolysaccharide binding protein expression in a rat model of alcoholic liver disease. Am J Pathol. 152:1998;841-849.
46. Liu S, Khemlani LS, Shapiro RA, Johnson ML, Liu K, Geller DA, et al. Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemia. Infect Immun. 66:1998;5089-5098.
47. Ahmad N, Gardner CR, Yurkow EJ, Laskin DL. Inhibition of macrophages with gadolinium chloride alters intercellular adhesion molecule-1 expression in the liver during acute endotoxemia in rats. Hepatology. 29:1999;728-736.
48. Rüttinger D, Vollmar B, Wanner GA, Messmer K. In vivo assessment of hepatic alterations following gadolinium chloride-induced Kupffer cell blockade. J Hepatol. 25:1996;960-967.
49. Armbrust T, Ramadori G. Functional characterization of two different Kupffer cell populations of normal rat liver. J Hepatol. 25:1996;518-528.
50. 2 is oxygen dependent in perfused rat liver. Am J Physiol. 275:1998;G542-G549.
51. Su GL, Simmons RL, Wang SC. Lipopolysaccharide binding protein participation in cellular activation by LPS. Crit Rev Immunol. 15:1995;201-214.
52. Wan Y, Freeswick PD, Khemlani LS, Kispert PH, Wang SC, Su GL, et al. Role of lipopolysaccharide (LPS), interleukin-1, interleukin-6, tumor necrosis factor, and dexamethasone in regulation of LPS-binding protein expression in normal hepatocytes and hepatocytes from LPS-treated rats. Infect Immun. 63:1995;2435-2442.
53. Schumann RR, Kirschning CJ, Unbehaun A, Aberle HP, Knope HP, Lamping N, et al. The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins. Mol Cell Biol. 16:1996;3490-3503.
54. Albano E, Clot P, Morimoto M, Tomasi A, Ingelman-Sundberg M, French SW. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology. 23:1996;155-163.
55. Ingelman-Sundberg M, Ekström G, Tindberg N. Lipid peroxidation dependent on ethanol-inducible cytochrome P-450 from rat liver. Adv Biosci. 71:1988;43-47.
56. Morimoto M, Hagbjork AL, Wan YJ, Fu PC, Clot P, Albano E, et al. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology. 21:1995a;1610-1617.
57. Koop DR, Chernosky A, Brass EP. Identification and induction of cytochrome P450 2E1 in rat Kupffer cells. J Pharmacol Exp Ther. 258:1991;1072-1076.
58. Morgan ET. Regulation of cytochromes P450 during inflammation and infection. Drug Metab Rev. 29:1997;1129-1188.
59. Badger DA, Kuester RK, Sauer JM, Sipes IG. Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity. Toxicology. 121:1997;143-153.
60. Ingelman-Sundberg M, Johansson I, Penttilä KE, Glaumann H, Lindros KO. Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver. Biochem Biophys Res Commun. 157:1988;55-60.
61. Kera Y, Sippel HW, Penttila KE, Lindros KO. Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes. Biochem Pharmacol. 36:1987;2003-2006.
62. Ishii H, Kurose I, Kato S. Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress. J Gastroenterol Hepatol. 12:1997;S272-S282.
63. Blum J, Fridovich I. Inactivation of glutathione peroxidase by superoxide radical. Arch Biochem Biophys. 240:1995;500-508.
64. Rouach H, Fataccioli V, Gentil M, French SW, Morimoto M, Nordmann R. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology. 25:1997;351-355.
65. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, et al. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Hepatology. 29:1999;1680-1689.