Human APE/Ref-1 protein

International Journal of Biochemistry and Cell Biology

Volumn 32, Issue 9, 2000, Pages 925-929

  Fritz, Gerhard ^a  

^a Institute of Toxicology   (Germany)

Author keywords

DNA repair; Gene expression; Oxidative stress; Redox regulation

Indexed keywords

APURINIC ACID; DNA; ENDONUCLEASE; TRANSCRIPTION FACTOR;

APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; HUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; TRANSCRIPTION REGULATION;

CARBON-OXYGEN LYASES; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENDODEOXYRIBONUCLEASES; GENE EXPRESSION; HUMANS; OXIDATION-REDUCTION; OXIDATIVE STRESS;

ALOCASIA MACRORRHIZOS;

EID: 0033740986     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(00)00045-5     Document Type: Article

References (16)

1. Mutagenesis by apurinic/apyrimidinic sites
2. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA binding activity
3. Identification of redox/repair protein Ref-1 as a potent activator of p53
4. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo
5. Phosphorylation of the DNA repair protein APE/Ref-1 by CKII affects redox regulation of AP-1
6. Human apurinic endonuclease gene (APE): Structure and genomic mapping (chromosome 14q11.2-12)
7. cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III
8. Site-directed mutagenesis of the human DNA repair enzyme HAP1: Identification of residues important for AP endonuclease and RNase H activity
9. Deletion analysis of human AP-endonuclease: Minimum sequence required for the endonuclease activity
10. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains
11. Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding
12. Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: A basis for its role in human disease
13. Negative regulation of the major human AP-endonuclease, a multifunctional protein
14. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress
15. Apurinic endonuclease (APE/Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation