Get a ligand, get a life: Integrins, signaling and cell survival

Journal of Cell Science

Volumn 115, Issue 19, 2002, Pages 3729-3738

  Stupack, Dwayne G ^a   Cheresh, David A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; Caspase; Cell adhesion; Integrin; Survival

Indexed keywords

CELL ADHESION MOLECULE; GROWTH FACTOR; INTEGRIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN INHIBITOR;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL COMMUNICATION; CELL INTERACTION; CELL SURVIVAL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; APOPTOSIS; CELL MEMBRANE; CELL SURVIVAL; EUKARYOTIC CELLS; EXTRACELLULAR MATRIX PROTEINS; HUMANS; INTEGRINS; LIGANDS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STRESS;

EID: 0036796781     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00071     Document Type: Article

References (140)

1. Abreu, M. T., Arnold, E. T., Chow, J. Y. and Barrett, K. E. (2001). Phosphatidylinositol 3-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells. Implications for inflammatory diarrheal states. J. Biol. Chem. 276, 47563-47574.
2. Algeciras-Schimnich, A., Shen, L., Barnhart, B. C., Murmann, A. E., Burkhardt, J. K. and Peter, M. E. (2002). Molecular ordering of the initial signaling events of CD95. Mol. Cell. Biol. 22, 207-220.
3. Almeida, E. A., Ilic, D., Han, Q., Hauck, C. R., Jin, F., Kawakatsu, H., Schlaepfer, D. D. and Damsky, C. H. (2000). Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J. Cell Biol. 149, 741-754.
4. Aoki, K., Kurooka, M., Chen, J. J., Petryniak, J., Nabel, E. G. and Nabel, G. J. (2001). Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Nat. Immunol. 2, 333-337.
5. Aoudjit, F. and Vuori, K. (2000). Engagement of the alpha2beta1 integrin inhibits Fas ligand expression and activation-induced cell death in T cells in a focal adhesion kinase-dependent manner. Blood 95, 2044-2051.
6. Aoudjit, F. and Vuori, K. (2001). Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J. Cell. Biol. 152, 633-643.
7. Araujo, H., Danziger, N., Cordier, J., Glowinski, J. and Chneiweiss, H. (1993). Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. J. Biol. Chem. 268, 5911-5920.
8. Arora, P. D., Ma, J., Min, W., Cruz, T. and McCulloch, C. A. (1995). Interleukin-1-induced calcium flux in human fibroblasts is mediated through focal adhesions. J. Biol. Chem. 270, 6042-6049.
9. Ashkenazi, A. and Dixit, V. M. (1999). Apoptosis control by death and decoy receptors. Curr. Opin. Cell Biol. 11, 255-260.
10. Avdi, N. J., Nick, J. A., Whitlock, B. B., Billstrom, M. A., Henson, P. M., Johnson, G. L. and Worthen, G. S. (2001). Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis. J. Biol. Chem. 276, 2189-2199.
11. Barazi, H. O., Zhou, L., Templeton, N. S., Krutzsch, H. C. and Roberts, D. D. (2002). Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 62, 1541-1548.
12. Bearz, A., Tell, G., Colombatti, A., Formisano, S. and Pucillo. C. (1998). Fibronectin binding promotes a PKC-dependent modulation of NF-kappa B in human T cells. Biochem. Biophys. Res. Commun. 243, 732-737.
13. Bonfoco, E., Chen, W., Paul, R., Cheresh, D. A. and Cooper, N. R. (2000). Beta1 integrin antagonism on adherent, differentiated human neuroblastoma cells triggers an apoptotic signaling pathway. Neuroscience 101, 1145-1152.
14. Borges, E., Jan, Y. and Ruoslahti, E. (2000). Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. J. Biol. Chem. 275, 39867-39873.
15. Boudreau, N. J. and Jones, P. L. (1999). Extracellular matrix and integrin signalling: the shape of things to come. Biochem. J. 339, 481-488.
16. Brassard, D. L., Maxwell, E., Malkowski, M., Nagabhushan, T. L., Kumar, C. C. and Armstrong, L. (1999). Integrin alpha(v)beta(3)-mediated activation of apoptosis. Exp. Cell Res. 251, 33-45.
17. Breitschopf, K., Haendeler, J., Malchow, P., Zeiher, A. M. and Dimmeler, S. (2000). Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation; molecular characterization of the involved signaling pathway. Mol. Cell Biol. 20, 1886-1896.
18. Brooks, P. C., Montgomery, A. M., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G. and Cheresh, D. A. (1994). Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
19. Brown, L. F., Dubin, D., Lavigne, L., Logan, B., Dvorak, H. F. and van de Water, L. (1993). Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing. Am. J. Pathol. 142, 793-801.
20. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J. and Greenberg, M. E. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868.
21. Buck, M., Poli, V., Hunter, T. and Chojkier, M. (2001). C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol. Cell 8, 807-816.
22. Byzova, T. V., Kim, W., Midura, R. J. and Plow, E. F. (2000). Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein. Exp. Cell Res. 254, 299-308.
23. Carragher, N. O., Fincham, V. J., Riley, D. and Frame, M. C. (2001). Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases. J. Biol. Chem. 276, 4270-4275.
24. Condorelli, G., Vigliotta, G., Iavarone, C., Caruso, M., Tocchetti, C. G., Andreozzi, F., Cafieri, A., Tecce, M. F., Formisano, P., Beguinot, L. et al. (1998). PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. EMBO J. 17, 3858-3866.
25. Condorelli, G., Vigliotta, G., Trencia, A., Maitan, M. A., Caruso, M., Miele, C., Oriente, F., Santopietro, S., Formisano, P. and Beguinot, F. (2001). Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells. Diabetes 50, 1244-1252.
26. Davis, G. E. (1992). Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites. Biochem. Biophys. Res. Commun. 182, 1025-1031.
27. de Fougerolles, A. R., Chi-Rosso, G., Bajardi, A., Gotwals, P., Green, C. D. and Koteliansky, V. E. (2000). Global expression analysis of extracellular matrix-integrin interactions in monocytes. Immunity 13, 749-758.
28. Deng, X., Xiao, L., Lang, W., Gao, F., Ruvolo, P. and May, W. S., Jr (2001). Novel role for JNK as a stress-activated Bcl2 kinase. J. Biol. Chem. 276, 23681-23688.
29. Duriez, F. J., Wong, F., Dorovini-Zis, K., Shahidi, R. and Karsan, A. (2000). A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. J. Biol. Chem. 275, 18099-18107.
30. Dvorak, H. E., Detmar, M., Claffey, K. P., Nagy, J. A., van de Water, L. and Senger, D. R. (1995). Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. Int. Arch. Allergy Immunol. 107, 233-235.
31. Eguchi, K. (2001). Apoptosis in autoimmune diseases. Intern. Med. 40, 275-284.
32. Eliceiri, B. P. (2001). Integrin and growth factor receptor crosstalk. Circ. Res. 89, 1104-1110.
33. Eliceiri, B. P., Klemke, R., Stromblad, S. and Cheresh, D. A. (1998). Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J. Cell Biol. 140, 1255-1263.
34. Falcioni, R., Antonini, A., Nistico, P., di Stefano, S., Crescenzi, M., Natali, P. G. and Sacchi, A. (1997). Alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines. Exp. Cell Res. 236, 76-85.
35. Fang, X., Yu, S., Eder, A., Mao, M., Bast, R. C., Jr, Boyd, D. and Mills, G. B. (1999). Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen- activated protein kinase pathway. Oncogene 18, 6635-6640.
36. Fenczik, C. A., Sethi, T., Ramos, J. W., Hughes, P. E. and Ginsberg, M. H. (1997). Complementation of dominant suppression implicates CD98 in integrin activation. Nature 390, 81-85.
37. Finbloom, D. S. and Wahl, L. M. (1989). Characterization of a novel low affinity receptor for IFN-gamma on adherent human monocytes by radioligand binding studies and chemical cross-linking. J. Immunol. 142, 2314-2320.
38. Flusberg, D. A., Numaguchi, Y. and Ingber, D. E. (2001). Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. Mol. Biol. Cell 12, 3087-3094.
39. Formstecher, E., Ramos, J. W., Fauquet, M., Calderwood, D. A., Hsieh, J. C., Canton, B,, Nguyen, X. T., Barnier, J. V., Camonis, J., Ginsberg, M. H. et al. (2001). PEA-15 mediates cytoplasmic sequesuation of ERK MAP kinase. Dev. Cell 1, 239-250.
40. Frisch, S. M. (1999). Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis. Curr. Biol. 9, 1047-1049.
41. Frisch, S. M. and Francis, H. (1994). Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626.
42. Frisch, S. M. and Ruoslahti, E. (1997). Integrins and anoikis. Curr. Opin. Cell Biol. 9, 701-706.
43. Frisch, S. M. and Screaton, R. A. (2001). Anoikis mechanisms. Curr. Opin. Cell Biol. 13, 555-562.
44. Frisch, S. M., Vuori, K., Kelaita, D. and Sicks, S. (1996). A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J. Cell Biol. 135, 1377-1382.
45. Fujita, E., Jinbo, A., Matuzaki, H., Konishi, H., Kikkawa, U. and Momoi, T. (1999). Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9. Biochem. Biophys. Res. Commun. 264, 550-555.
46. Gauthier, R., Harnois, C., Drolet, J. F., Reed, J. C., Vezina, A. and Vachon, P. H. (2001). Human intestinal epithelial cell survival: differentiation states-pecific control mechanisms. Am. J. Physiol. Cell Physiol. 280, C1540-C1554.
47. Gear, A. R., Simon, C. G. and Polanowska-Grabowska, R. (1997). Platelet adhesion to collagen activates a phosphoprotein complex of heat-shock proteins and protein phosphatase 1. J. Neural. Transm. 104, 1037-1047.
48. Geiger, B., Bershadsky, A., Pankov, R. and Yamada, K. M. (2001). Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat. Rev. Mol. Cell Biol. 2, 793-805.
49. Gervais, F. G., Singaraja, R., Xanthoudakis, S., Gutekunst, C. A., Leavitt, B. R., Metzler, M., Hackam, A. S., Tam, J., Vaillancourt, J. P., Houtzager, V. et al. (2002). Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat. Cell Biol. 4, 95-105.
50. Giancotti, F. G. and Ruoslahti, E. (1999). Integrin signaling. Science 285, 1028-1032.
51. Gilmore, A. P., Metcalfe, A. D., Romer, L. H. and Streuli, C. H. (2000). Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization. J. Cell Biol. 149, 431-446.
52. Gingras, A. C., Kennedy, S. G., O'Leary, M. A., Sonenberg, N. and Hay, N. (1998). 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 12, 502-513.
53. Gomez-Angelats, M. and Cidlowski, J. A. (2001). Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis. J. Biol. Chem. 276, 44944-44952.
54. Grabovsky, V, Feigelson, S., Chen, C., Bleijs, D. A., Peled, A., Cinamon, G., Baleux, E, Arenzana-Seisdedos, E, Lapidot, T., van Kooyk, Y. et al. (2000). Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulate, leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions. J. Exp. Med. 192, 495-506.
55. Grad, J. M., Zeng, X. R. and Boise, L. H. (2000). Regulation of Bcl-xL: a little bit of this and a little bit of STAT. Curr. Opin. Oncol. 12, 543-549.
56. Green, D. R. and Reed, J. C. (1998). Mitochondria and apoptosis. Science 281, 1309-1312.
57. Han, D. C., Rodriguez, L. G. and Guan, J. L. (2001). Identification of a novel interaction between integrin beta1 and 14-3-3beta. Oncogene 20, 346-357.
58. Hayakawa, J., Ohmichi, M., Kurachi, H., Kanda, Y., Hisamoto, K., Nishio, Y., Adachi, K., Tasaka, K., Kanzaki, T. and Murata, Y. (2000). Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res. 60, 5988-5994.
59. Herbert, T. P., Tee, A. R. and Proud, C. G. (2002). The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. J. Biol. Chem. 277, 11591-11596.
60. Hostein, I., Robertson, D., DiStefano, E, Workman, P. and Clarke, P. A. (2001). Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino- 17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 61, 4003-4009.
61. Howe, A. K. and Juliano, R. L. (2000). Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat. Cell Biol. 2, 593-600.
62. Ingber, D. E. (1992). Extracellular matrix as a solid-state regulator in angiogenesis: identification of new targets for anti-cancer therapy. Semin. Cancer Biol. 3, 57-63.
63. Keely, P. J., Rusyn, E. V., Cox, A. D. and Parise, L. V. (1999). R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells. J. Cell Biol. 145, 1077-1088.
64. Klinowska, T. C., Soriano, J. V., Edwards, G. M., Oliver, J. M., Valentijn, A. J., Montesano, R. and Streuli, C. H. (1999). Laminin and beta1 integrins are crucial for normal mammary gland development in the mouse. Dev. Biol. 215, 13-32.
65. Koo, L. Y., Irvine, D. J., Mayes, A. M., Lauffenburger, D. A. and Griffith, L. G. (2002). Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. J. Cell Sci. 115, 1423-1433.
66. Kozlova, N. L, Morozevich, G. E., Chubukina, A. N. and Berman, A. E. (2001). Integrin alphavbeta3 promotes anchorage-dependent apoptosis in human intestinal carcinoma cells. Oncogene 20, 4710-4717.
67. Krzyzowska, M., Sabri, F., de Milito, A., Missallidis, C., Schollenberger, A., Niemialtowski, M. G. and Chiodi, F. (2001). Cross-linking of LFA-1 molecule enhances Fas mediated apoptosis of Jurkat and Burkitt lymphoma cell lines. Cell Death Differ. 8, 1123-1124.
68. Kulms, D., Dussmann, H., Poppelmann, B., Slander, S., Schwarz, A. and Schwarz, T. (2002). Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1). Cell Death Differ. 9, 598-608.
69. Kuzuya, M., Satake, S., Ramos, M. A., Kanda, S., Koike, T., Yoshino, K., Ikeda, S. and Iguchi, A. (1999). Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice. Exp. Cell Res. 248, 498-508.
70. Law, S. E, O'Neill, G. M., Fashena, S. J., Einarson, M. B. and Golemis, E. A. (2000). The docking protein HEF1 is an apoptotic mediator at focal adhesion sites. Mol. Cell. Biol. 20, 5184-5195.
71. Lee, J. M. and Bernstein, A. (1995). Apoptosis, cancer and the p53 tumour suppressor gene. Cancer Metastasis Rev. 14, 149-161.
72. Lee, J. W. and Juliano, R. L. (2000). alpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway. Mol. Biol. Cell 11, 1973-1987.
73. Lesay, A., Hickman, J. A. and Gibson, R. M. (2001). Disruption of focal adhesions mediates detachment during neuronal apoptosis. Neuroreport 12, 2111-2115.
74. Leverrier, Y., Thomas, J., Mathieu, A. L., Low, W., Blanquier, B. and Marvel, J. (1999). Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells. Cell Death Differ. 6, 290-296.
75. Li, E., Stupack, D. G., Brown, S. L., Klemke, R., Schlaepfer, D. D. and Nemerow, G. R. (2000). Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J. Biol. Chem. 275, 14729-14735.
76. Li, L., Okura, M. and Imamoto, A. (2002). Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion. Mol. Cell Biol. 22, 1203-1217.
77. Lin, T. H., Chen, Q., Howe, A. and Juliano, R. L. (1997). Cell anchorage permits efficient signal transduction between ras and its downstream kinases. J. Biol. Chem. 272, 8849-8852.
78. Lin, T. H., Rosales, C., Mondal, K., Bolen, J. B., Haskill, S. and Juliano, R. L. (1995). Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase. J. Biol. Chem. 270, 16189-16197.
79. Lu, Y., Lin, Y. Z., LaPushin, R., Cuevas, B., Fang, X., Yu, S. X., Davies, M. A., Khan, H., Furui, T., Mao, M. et al. (1999). The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene 18, 7034-7045.
80. Maeshima, Y., Sudhakar, A., Lively, J. C., Ueki, K., Kharbanda, S., Kahn, C. R., Sonenberg, N., Hynes, R. O. and Kalluri, R. (2002). Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science 295, 140-143.
81. Mandlekar, S., Yu, R., Tan, T. H. and Kong, A. N. (2000). Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells. Cancer Res. 60, 5995-6000.
82. Maslyar, D. J., Aoki, M. and Vogt, P. K. (2001). The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3. Oncogene 20, 5087-5092.
83. Matter, M. L. and Ruoslahti, E. (2001). A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription. J. Biol. Chem. 276, 27757-27763.
84. Meng, X. W., Heldebrant, M. P. and Kaufmann, S. H. (2002). Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain. J. Biol. Chem. 277, 3776-3783.
85. Meredith, J. E., Jr, Fazeli, B. and Schwartz, M. A. (1993). The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
86. Miranti, C. K., Ohno, S. and Brugge, J. S. (1999). Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc. J. Biol. Chem. 274, 10571-10581.
87. Miyamoto, S., Teramoto, H., Gutkind, J. S. and Yamada, K. M. (1996). Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135, 1633-1642.
88. Moreno-Manzano, V., Lucio-Cazana, J., Konta, T., Nakayama, K. and Kitamura, M. (2000). Enhancement of TNF-alpha-induced apoptosis by immobilized arginine- glycine-aspartate: involvement of a tyrosine kinase-dependent, MAP kinase-independent mechanism. Biochem. Biophys. Res. Commun. 277, 293-298.
89. Moulian, N. and Berrih-Aknin, S. (1998). Fas/APO-1/CD95 in health and autoimmune disease: thymic and peripheral aspects. Semin. Immunol. 10, 449-456.
90. Muzio, M., Stockwell, B. R., Stennicke, H. R., Salvesen, G. S. and Dixit, V. M. (1998). An induced proximity model for caspase-8 activation. J. Biol. Chem. 273, 2926-2930.
91. Narasimhan, C. and Lai, C. S. (1989). Conformational changes of plasma fibronectin detected upon adsorption to solid substrates: a spin-label study. Biochemistry 28, 5041-5046.
92. Nemerow, G. R. and Cheresh, D. A. (2002). Herpesvirus hijacks an integrin. Nat. Cell Biol. 4, E69-E71.
93. Parise, L. V., Lee, J. and Juliano, R. L. (2000). New aspects of integrin signaling in cancer. Semin. Cancer Biol. 10, 407-414.
94. Paul, C., Manero, E, Gonin, S., Kretz-Remy, C., Virot, S. and Arrigo, A. P. (2002). Hsp27 as a negative regulator of cytochrome C release. Mol. Cell. Biol. 22, 816-834.
95. Persad, S., Attwell, S., Gray, V., Mawji, N., Deng, J. T., Leung, D., Yan, J., Sanghera, J., Walsh, M. P. and Dedhar, S. (2001). Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J. Biol. Chem. 276, 27462-27469.
96. Petersen, O. W., Ronnov-Jessen, L., Weaver, V. M. and Bissell, M. J. (1998). Differentiation and cancer in the mammary gland: shedding light on an old dichotomy. Adv. Cancer Res. 75, 135-161.
97. Petitclerc, E., Stromblad, S., von Schalscha, T. L., Mitjans, F., Piulats, J., Montgomery, A. M., Cheresh, D. A. and Brooks, P. C. (1999). Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. Cancer Res. 59, 2724-2730.
98. Petosa, C., Masters, S. C., Bankston, L. A., Pohl, J., Wang, B., Fu, H. and Liddington, R. C. (1998). 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J. Biol. Chem. 273, 16305-16310.
99. Polanowska-Grabowska, R. and Gear, A. R. (2000). Heat-shock proteins and platelet function. Platelets 11, 6-22.
100. Polunovsky, V. A., Rosenwald, I. B., Tan, A. T., White, J., Chiang, L., Sonenberg, N. and Bitterman, P. B. (1996). Translational control of programmed cell death: eukaryotic translation initiation factor 4F blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc. Mol. Cell. Biol. 16, 6573-6581.
101. Ramarli, D., Scupoli, M. T., Fiorini, E., Poffe, O., Brentegani, M., Villa, A., Cecchini, G., Tridente, G. and Marchisio, P. C. (1998). Thymocyte contact or monoclonal antibody-mediated clustering of 3beta1 or 6beta4 integrins activate interleukin-6 (IL-6) transcription factors (NF-kappaB and NF-IL6) and IL-6 production in human thymic epithelial cells. Blood 92, 3745-3755.
102. Ramos, J. W., Kojima, T. K., Hughes, P. E., Fenczik, C. A. and Ginsberg, M. H. (1998). The death effector domain of PEA-15 is involved in its regulation of integrin activation. J. Biol. Chem. 273, 33897-33900.
103. Ranger, A. M., Malynn, B. A. and Korsmeyer, S. J. (2001). Mouse models of cell death. Nat. Genet. 28, 113-118.
104. Reed, J. C. (1999). Dysregulation of apoptosis in cancer. J. Clin. Oncol. 7, 2941-2953.
105. Rupp, P. A. and Little, C. D. (2001). Integrins in vascular development. Circ. Res. 89, 566-572.
106. Sadek, C. M. and Allen-Hoffmann, B. L. (1994). Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway. J. Biol. Chem. 269, 31505-31509.
107. Salvesen, G. S. and Duckett, C. S. (2002). IAP proteins: blocking the road to death's door. Nat. Rev. Mol. Cell. Biol. 3, 401-410.
108. Scatena, M., Almeida, M., Chaisson, M. L., Fausto, N., Nicosia, R. F. and Giachelli, C. M. (1998). NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival. J. Cell Biol. 141, 1083-1093.
109. Schlaepfer, D. D., Hauck, C. R. and Sieg, D. J. (1999). Signaling through focal adhesion kinase. Prog. Biophys. Mol. Biol. 71, 435-478.
110. Schleiffenbaum, B. and Fehr, J. (1990). The tumor necrosis factor receptor and human neutrophil function. Deactivation and cross-deactivation of tumor necrosis factor-induced neutrophil responses by receptor downregulation. J. Clin. Invest. 86, 184-195.
111. Schulze, A., Lehmann, K., Jefferies, H. B., McMahon, M. and Downward, J. (2001). Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev. 15, 981-994.
112. Schwartz, M. A. (2001). Integrin signaling revisited. Trends Cell Biol. 11, 466-470.
113. Schwartz, M. A. and Assoian, R. K. (2001). Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. J. Cell Sci. 114, 2553-2560.
114. Schwartz, M. A. and Shattil, S. J. (2000). Signaling networks linking integrins and rho family GTPases. Trends Biochem. Sci. 25, 388-391.
115. Scott, P. H., Brunn, G. J., Kohn, A. D., Roth, R. A. and Lawrence, J. C., Jr (1998). Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 95, 7772-7777.
116. Segaert, S., Garmyn, M., Degreef, H. and Bouillon, R. (1998). Anchorage-dependent expression of the vitamin D receptor in normal human keratinocytes. J. Invest. Dermatol. 111, 551-558.
117. Shain, K. H., Landowski, T. H. and Dalton, W. S. (2002). Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IIL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines. J. Immunol. 168, 2544-2553.
118. Shim, S. R., Kook, S., Kim, J. I. and Song, W. K. (2001). Degradation of focal adhesion proteins paxillin and p130cas by caspases or calpains; in apoptotic rat-1 and L929 cells. Biochem. Biophys. Res. Commun. 286, 601-608.
119. Sonoda, Y., Matsumoto, Y., Funakoshi, M., Yamamoto, D., Hanks, S. K. and Kasahara, T. (2000). Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J. Biol. Chem. 275, 16309-16315.
120. Srivastava, R. K., Mi, Q. S., Hardwick, J. M. and Longo, D. L. (1999). Deletion of the loop region of Bcl-2 completely blocks pactitaxel- induced apoptosis. Proc. Natl. Acad. Sci. USA 96, 3775-3780.
121. Storgard, C. M., Stupack, D. G., Jonczyk, A., Goodman, S. L., Fox, R. I. and Cheresh, D. A. (1999). Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. J. Clin. Invest. 103, 47-54.
122. Strasser, A., O'Connor, L. and Dixit, V. M. (2000). Apoptosis signaling. Annu. Rev. Biochem. 69, 217-245.
123. Stromblad, S., Becker, J. C., Yebra, M., Brooks, P. C. and Cheresh, D. A. (1996). Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J. Clin. Invest. 98, 426-433.
124. Stupack, D. G., Li, E., Silletti, S. A., Kehler, J. A., Geahlen, R. L., Hahn, K., Nemerow, G. R. and Cheresh, D. A. (1999). Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J. Cell Biol. 144, 777-788.
125. Stupack, D. G., Puente, X. S., Boutsaboualoy, S., Storgard, C. M. and Cheresh, D. A. (2001). Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J. Cell Biol. 155, 459-470.
126. Tamura, M., Gu, J., Tran, H. and Yamada, K. M. (1999). PTEN gene and integrin signaling in cancer. J. Natl. Cancer Inst. 91, 1820-1828.
127. Thakkar, H., Chen, X., Tyan, E, Gim, S., Robinson, H., Lee, C., Pandey, S. K., Nwokorie, C., Onwudiwe, N. and Srivastava, R. K. (2001). Prosurvival function of Akt/protein kinase B in prostate cancer cells: relationship with trail resistance. J. Biol. Chem. 276, 38361-38369.
128. Tomasini, B. R. and Mosher, D. F. (1988). Conformational states of vitronectin: preferential expression of an antigenic epitope when vitronectin is covalently and noncovalently complexed with thrombin-antithrombin III or treated with urea. Blood 72, 903-912.
129. Uhm, J. H., Dooley, N. P., Kyritsis, A. P., Rao, J. S. and Gladson, C. L. (1999). Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clin. Cancer Res. 5, 1587-1594.
130. van Hemert, M. J., Steensma, H. Y. and van Heusden, G. P. (2001). 14-3-proteins: key regulators of cell division, signalling and apoptosis. Bioessays 23, 936-946.
131. van Kooyk, Y. and Figdor, C. G. (2000). Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr. Opin. Cell Biol. 12, 542-547.
132. Vitale, M., di Matola, T., Bifulco, M., Casamassima, A., Fenzi, G. and Rossi, G. (1999). Apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression. FEBS Lett. 462, 57-60.
133. Vogel, V., Thomas, W. E., Craig, D. W., Krammer, A. and Baneyx, G. (2001). Structural insights into the mechanical regulation of molecular recognition sites. Trends Biotechnol. 19, 416-423.
134. Wahl, G. M. and Carr, A. M. (2001). The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat. Cell Biol. 3, E277-E286.
135. Wolf, B. B. and Green, D. R. (1999). Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 274, 20049-20052.
136. Xu, J., Rodriguez, D., Petitclerc, E., Kim, J. J., Hangai, M., Yuen, S. M., Davis, G. E. and Brooks, P. C. (2001). Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. J. Cell Biol. 154, 1069-1079.
137. Yamada, K. M. and Araki, M. (2001). Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci. 114, 2375-2382.
138. Zamarron, C., Ginsberg, M. H. and Plow, E. F. (1990). Monoclonal antibodies specific for a conformationally altered state of fibrinogen. Thromb. Haemost. 64, 41-46.
139. Zhou, H., Li, X. M., Meinkoth, J. and Pittman, R. N. (2000). Akt regulates cell survival and apoptosis at a postmitochondrial level. J. Cell Biol. 151, 483-494.
140. Zhuang, S., Demirs, J. T. and Kochevar, I. E. (2001). Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation. Oncogene 20, 6764-6776.