Thymocyte contact or monoclonal antibody-mediated clustering of α3β1 or α2β4 integrins activate interleukin-6 (IL-6) transcription factors (NF- κB and NF-IL6) and IL-6 production in human thymic epithelial cells

Blood

Volumn 92, Issue 10, 1998, Pages 3745-3755

  Ramarli, Dunia ^a   Scupoli, Maria Teresa ^b   Fiorini, Emma ^b   Poffe, Ornella ^b   Brentegani, Monica ^b   Villa, Antonello ^b   Cecchini, Germana ^b   Tridente, Giuseppe ^b   Marchlsio, Pier Carlo ^b  

^a Ist di Immunol e Malat Infettive   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; INTERLEUKIN 6; MONOCLONAL ANTIBODY; SERINE;

ARTICLE; COCULTURE; CONTROLLED STUDY; CROSS LINKING; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; PHOSPHORYLATION; PRIORITY JOURNAL; THYMOCYTE;

EID: 0032533242     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.10.3745     Document Type: Article

References (46)

1. Boyd RL, Tucek CL, Godfrey DI, Izon DJ, Wilson TJ, Davidson NJ, Beam AGD, Ladyman HM, Ritter MA, Hugo P: The thymic microenvironment. Immunol Today 14:445, 1993
2. Crisa L, Cirulli V, Ellisman MH, Ishii JK, Elices MJ, Salomon DR: Cell adhesion and migration are regulated at distinct stages of thymic T cell development: The roles of fibronectine, VLA4, and VLA5. J Exp Med 184:215, 1996
3. Schluns KS, Cook JE, Le PT: TGF-beta differentially modulates epidermal growth factor-mediated increases in leukemia-inhibitory factor, IL-6, IL-1 alpha, and IL-1 beta in human thymic epithelial cells. J Immunoll 58:2704, 1997
4. Meilin A, Shoham J, Schreiber L, Sharaby Y: The role of thymocytes in reulating thymic epithelial cell growth and function. Scand J Immunol 42:185, 1995
5. Couture C, Amarante-Mendes G, Potworowsky E: Tyrosin kinase activation in thymic epithelial cells: Necessity of thymocyte contact through the gp23/45/90 adhesion complex. Eur J Immunol 22:2579, 1992
6. Cohen-Kaminski S, Devergne O, Delattre RM, Klingel-Schmitt I, Emilie D, Galanaud P, Berrih-Aknin S: Interleukin 6 overproduction by cultured thymic epithelial cells from patients with myasthenia Gravis is potentially involved in thymic iperplasia. Eur Cytokine Netw 4:121, 1993
7. Henttinen T, Levy DE, Silvennoinen O, Hurme M: Activation of the signal trasducer and transcription (STAT) signaling pathway in a primary T cell response. J Immunol 155:4582, 1995
8. Quentmeier H, Klaucke J, Muhlradt PF, Drexler HG: Role of IL-6, IL-2, and IL-4 in the in vitro induction of cytotoxic T cells. J Immunol 149:3316, 1992
9. Adkins B, Chun K, Hamilton K, Nassiri M: Naive murine neonatal T cells undergo apoptosis in response to primary stimulation. J Immunol 157:1343, 1996
10. Borsellino N, Belldegrun A, Bonavida B: Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Cancer Res 55:4633, 1995
11. Akira S, Kishimoto T: NF-IL6 and NF-κB in cytokine gene regulation. Adv Immunol 65:25, 1997
12. Rola-Pleszczynsky M, Stankova J: Leukotriene B4 enhances interIeukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: Transcriptional and post-transcriptional mechanism. Blood 80:1004, 1992
13. Matsusaka T, Fujikawa K, Nishio T, Mukaida N, Matsushima K, Kishimoto T, Akira S: Transcription factors NF-EL6 and NF-κB sinergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90:10193, 1993
14. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T: Nuclear factor for IL-6 (NF-IL6) expression is a member of C/EBP family. EMBO J 9:1897, 1990
15. Descombes P, Schibler U: A liver enriched transcriptional activator protein, LAP and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569, 1991
16. Ossipow V, Descombes P, Schibler U: CCAAT/enhancer binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc Natl Acad Sci USA 90:8219, 1993
17. Wegner M, Cao Z, Rosenfeld MG: Calcium-regulated phosphorylation within the leucin zipper of C/EBPβ. Science 256:370, 1992
18. Williams SC, Baer M, Dillner AJ, Johnson PF: CRP2 (C/EBPβ) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J 14:3170, 1995
19. Baldwin AS: The NF-κB and IκB proteins: New discoveries and insights. Annu Rev Immunol 14:649, 1996
20. Palombella VJ, Rando OJ, Godberg AL, Maniatis T: The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78:773, 1994
21. Imbert V, Rupee RA, Livolsi A, Pahl HL, Traenckner BM, Muelle-Dieckmann C, Farahifar D, Rossi B, Auberger P, Bauerle P, Peyron JF: Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α. Cell 86:787, 1996
22. Ramarli D, Reina S, Merola M, Scupoli MT, Poffe O, Riviera AP, Brentegani M, Fiorini E, Vella A, Varnier O, Tridente G: HTLV-IIIB Infection of human thymic epithelial cells: Viral replication correlates with the induction of NF-κB binding activity in cells activated by cell adhesion. AIDS Res Hum Retrovirus 12:1217, 1996
23. Patel D, Wee SW, Whichard LP, Bowen MA, Pesando JM, Aruffo A, Haynes BF: Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cell. J Exp Med 181:1563, 1995
24. Baum LG, Pang M, Perillo NL, Wu T, Deleagene A, Uittenbogaart CH, Fukudu M, and Seilhamer JJ: Human thymic epithelial cells express and endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J Exp Med 181:877, 1995
25. Lee MG, Sharrow SO, Fair AG, Singer S, Udey MC: Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells. J Immunol 152:5653, 1994
26. Juliano RL, Haskill S: Signal transduction from the extracellular matrix. J Cell Biol 120:577, 1993
27. Green H, Kehinde O, Thomas J: Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci USA 76:5665, 1979
28. vβ5) and their relationship with the cytoskeleton and the basement membrane matrix in cultured human keratinocytes. J Cell Biol 112:761, 1991
29. Giunta M, Favre A, Ramarli D, Grossi C, Corte G: A novel integrin is involved in thymocyte-thymic epithelial cell interaction. J Exp Med 173:1537, 1991
30. Schreiber E, Matthias P, Muller MM, Schaffner W: Rapid detection of octamer binding proteins with "mini extracts" prepared from a small number of cells. Nucleic Acids Res 17:6419, 1989
31. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440, 1985
32. Salomon D, Crisa L, Mojcik CF, Ishii JK, Klier G, Shevach EM: Vascular adhesion molecule-1 is expressed by cortical thymic epithelial cells and mediate thymocyte adhesion. Implications for the function of α4β1 (VLA4) integrin in T-cell development. Blood 89:2461, 1997
33. Singer HK, Wolf LS, Lobach DF, Denning SM, Tuck DT, Robertson AL, Haynes BF: Human thymocyte bind to autologous and allogeneic thymic epithelial cells in vitro. Proc Natl Acad Sci USA 83:6588, 1986
34. Clark EA, Brugge S: Integrini and signal transduction pathways: The road taken. Science 268:233, 1995
35. LeClear KP, Blanar MA, Sharp PA: The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc Natl Acad Sci USA 89:8145, 1992
36. Carter WG, Ryan MC, Gahr PJ: Epiligrin: A new adhesion ligand for integrin a3b1 in epithelial basement membranes. Cell 65:599, 1991
37. Branderberger R, Kammerer RA, Engel J, Criquet M: Native chick laminin-4 containing the b2 chain (s-laminin) promotes motor axon growth. J Cell Biol 135:1583, 1996
38. Delwel GO, de Melkerl AA, Hogervorst F, Jaspals LH, Fies DL, Kuikman I, Lindblom A, Paulsson M, Timpl R, Sonnemberg A: Distinct and overlapping ligand specificities of the a3b1 and a6b1 integrins: Recognition of laminin isoforms. Mol Biol Cell 5:203, 1994
39. Brown E: Adhesive interaction in the immune system. Trends Cell Biol 7:289, 1997
40. Symington BE, Takada Y, Carter WC: Interaction of integrins α3β1 and α2β1: Potential role in keratinocyte intercellular adhesion. J Cell Biol 120:523, 1993
41. Salomon DR, Mojcik CF, Chang AC, Wadsworth S, Adams DH, Coligan JE, Shevach EM: Constitutive activation of integrin α4β1 defines a unique stage of human thymocyte development. J Exp Med 179:1573, 1994
42. Sànchez-Aparicio P, Martinez de Velasco AM, Niessen CM, Borradori L, Kuikman I, Huisman EHM, Fässler R, Owaribe K, Sonnenberg A: The subcellular distribution of the high molecular mass, HD1, is determined by the cytoplasmic domain of the integrin b4 subunit. J Cell Sci 110:169, 1997
43. Mainiero F, Pepe A, Wari KK, Spinardi L, Mohammad M, Schlessinger J, Giancotti FG: Signal transduction by the α6β4 integrin: Distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J 14:4470, 1995
44. Lin TH, Rosales C, Mondal K, Bolen JB, Haskill S, Juliano RL: Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. J Biol Chem 270:16189, 1995
45. Wolf SS, Cohen A: Expression of cytokines and their receptors by human thymocytes and thymic stromal cells. Immunology 77:362, 1992
46. Screpanti J, Scarpa S, Meco D, Bellavia D, Stuppia L, Frati L, Modesti A, Gulino A: Epidermal growth factor promotes a neural phenotype in thymic epithelial cells and enhances neuropoietic cytokine expression. J Cell Biol 130:183, 1995