Analysis of the transcriptional program induced by Raf in epithelial cells

Genes and Development

Volumn 15, Issue 8, 2001, Pages 981-994

  Schulze, Almut ^a   Lehmann, Kerstin ^a   Jefferies, Harold B J ^a   McMahon, Martin ^b   Downward, Julian ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Matrix; Microarray; Raf; Ras; Transcription

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CELL SURFACE PROTEIN; CYTOKINE; CYTOSKELETON PROTEIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR; VIRUS VECTOR;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL ADHESION; CELL PROLIFERATION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; RETROVIRUS; UNINDEXED SEQUENCE;

APOPTOSIS; BLOTTING, NORTHERN; CELL DIVISION; CYTOCHROME C GROUP; DOWN-REGULATION; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; IMMUNOBLOTTING; MITOGEN-ACTIVATED PROTEIN KINASE 1; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UP-REGULATION;

UNIDENTIFIED RETROVIRUS;

EID: 0035871383     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.191101     Document Type: Article

References (47)

1. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
2. Extrinsic regulators of epithelial tumor progression: Metalloproteinases
3. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
4. Ras oncogenes in human cancer: A review
5. Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1
6. The hemostatic system as a regulator of angiogenesis
7. Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis
8. Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation
9. The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation
10. Cellular survival: A play in three Akts
11. Growth factors from murine sarcoma virus-transformed cells
12. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
13. Ras signalling and apoptosis
14. How BAD phosphorylation is good for survival
15. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
16. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
17. Disruption of epithelial cell-matrix interactions induces apoptosis
18. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
19. Induction of putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted complex hybridization
20. Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo
21. Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F
22. The transcriptional program in the response of human fibroblasts to serum
23. Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase
24. Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway
25. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
26. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
27. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal
28. High density synthetic oligonucleotide arrays
29. Expression monitoring by hybridization to high-density oligonucleotide arrays
30. Ras effectors
31. Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1
32. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes
33. Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells
34. The integrin alpha 6 beta 4 and the biology of carcinoma
35. Growth factor activation of MAP kinase requires cell adhesion
36. Regulation of Bcl-xL expression in human keratinocytes by cell- substratum adhesion and the epidermal growth factor receptor
37. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
38. Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis
39. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
40. Understanding ras: "It ain't over 'til it's over."
41. Rsk1 mediates a MEK-MAP kinase cell survival signal
42. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
43. p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway
44. Regulation of transcription by MAP kinase cascades
45. Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase
46. Genome-wide expression monitoring in Saccharomyces cerevisiae
47. A genome-wide survey of RAS transformation targets