Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo

Journal of Cell Biology

Volumn 154, Issue 5, 2001, Pages 1069-1079

  Xu, Jingsong ^a   Rodriguez, Dorothy ^a   Petitclerc, Eric ^a   Kim, Jenny J ^a   Hangai, Masanori ^b   Moon Yuen, S ^b   Davis, George E ^c   Brooks, Peter C ^a  

^a Kaplan Cancer Center   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Angiogenesis; Cryptic sites; ECM; Migration; Tumor

Indexed keywords

COLLAGEN TYPE 4; EPITOPE; INTEGRIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL; CELL INTERACTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; TUMOR GROWTH; UMBILICAL VEIN;

ANIMALS; ANTIBODIES, MONOCLONAL; BASEMENT MEMBRANE; BINDING SITES; CELL ADHESION; CELL MOVEMENT; CHICK EMBRYO; COLLAGEN; CORNEAL NEOVASCULARIZATION; DIABETIC RETINOPATHY; ENDOTHELIUM, VASCULAR; EPITOPES; HUMANS; MATRIX METALLOPROTEINASE 2; MELANOMA; MICE; MICROSCOPY, FLUORESCENCE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE HYDROLASES; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, VITRONECTIN; RETINAL VESSELS; SKIN; TUMOR CELLS, CULTURED;

EID: 0035802109     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200103111     Document Type: Article

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