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Volumn 98, Issue 2, 1996, Pages 426-433

Suppression of p53 activity and p21(WAF1/CIP1) expression by vascular cell integrin αvβ3 during angiogenesis

Author keywords

apoptosis; bcl 2; cell cycle; endothelial cells; gene expression

Indexed keywords

DNA; INTEGRIN; MESSENGER RNA; PROTEIN P21; PROTEIN P53;

EID: 0030038229     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118808     Document Type: Article
Times cited : (353)

References (42)
  • 1
  • 2
    • 0028670833 scopus 로고
    • Integrin αvβ3 antagonists promote further tumor regression by inducing apoptosis of angiogenic bloodvessels
    • Brooks, P.C., A.M.P. Montgomery, M. Rosenfeld, R.A. Reisfeld, T. Hu, G. Klier, and D.A. Cheresh. 1994. Integrin αvβ3 antagonists promote further tumor regression by inducing apoptosis of angiogenic bloodvessels. Cell. 79: 1157-1164.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1    Montgomery, A.M.P.2    Rosenfeld, M.3    Reisfeld, R.A.4    Hu, T.5    Klier, G.6    Cheresh, D.A.7
  • 3
    • 0028362876 scopus 로고
    • Requirement of vascular integrin αvβ3 for angiogenesis
    • Brooks, P.C., R.A.F. Clark, and D.A. Cheresh. 1994. Requirement of vascular integrin αvβ3 for angiogenesis. Science (Wash. DC). 264:569-571.
    • (1994) Science (Wash. DC) , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.F.2    Cheresh, D.A.3
  • 5
    • 0028335948 scopus 로고
    • Anchorage dependence, integrins, and apoptosis
    • Ruoslahti, E., and J.C. Reed. 1994. Anchorage dependence, integrins, and apoptosis. Cell. 77:477-478.
    • (1994) Cell , vol.77 , pp. 477-478
    • Ruoslahti, E.1    Reed, J.C.2
  • 6
    • 0027752979 scopus 로고
    • A link between cyclin A expression and adhesion-dependent cell cycle progression
    • Guadagno, T.M., M. Ohtsubo, J.M. Roberts, and R.K. Assoian. 1993. A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (Wash. DC). 262:1572-1575.
    • (1993) Science (Wash. DC) , vol.262 , pp. 1572-1575
    • Guadagno, T.M.1    Ohtsubo, M.2    Roberts, J.M.3    Assoian, R.K.4
  • 7
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X., and A.J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA. 91:3602-3606.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 8
    • 0029050533 scopus 로고
    • Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
    • Almasan, A., Y. Yin, R.E. Kelly, E.Y.-H.P. Lee, A. Bradley, W. Li, J.R. Bertino, and G.M. Wahl. 1995. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA. 92:5436-5440.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3    Lee, E.Y.-H.P.4    Bradley, A.5    Li, W.6    Bertino, J.R.7    Wahl, G.M.8
  • 12
    • 0029916820 scopus 로고    scopus 로고
    • Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle
    • Boudreau, N., Z. Werb, and M.J. Bissell. 1996. Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc. Natl. Acad. Sci. USA. 93:3509-3513.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3509-3513
    • Boudreau, N.1    Werb, Z.2    Bissell, M.J.3
  • 15
    • 0028292480 scopus 로고
    • Identification of a p53-dependent negative response element in the bcl-2 gene
    • Miyashita, T.S., M. Harigari, M. Kanada, and J.C. Reed. 1994. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res. 54:3131-3135.
    • (1994) Cancer Res. , vol.54 , pp. 3131-3135
    • Miyashita, T.S.1    Harigari, M.2    Kanada, M.3    Reed, J.C.4
  • 16
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T.S., and J.C. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.S.1    Reed, J.C.2
  • 17
    • 0020773108 scopus 로고
    • A practical approach for quantitating specific mRNA by solution hybridization
    • Durnam, D.M., and R.P. Palmiter. 1983. A practical approach for quantitating specific mRNA by solution hybridization. Anal. Biochem. 131:385-393.
    • (1983) Anal. Biochem. , vol.131 , pp. 385-393
    • Durnam, D.M.1    Palmiter, R.P.2
  • 18
    • 0027324739 scopus 로고
    • The coupling between the transforming growth factor a and the epidermal growth factor receptor during rat liver regeneration
    • Strömblad, S., and G. Andersson. 1993. The coupling between the transforming growth factor a and the epidermal growth factor receptor during rat liver regeneration. Exp. Cell Res. 204:321-328.
    • (1993) Exp. Cell Res. , vol.204 , pp. 321-328
    • Strömblad, S.1    Andersson, G.2
  • 19
    • 0026793958 scopus 로고
    • Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the bcl-2 oncoprotein
    • Cazals-Hatem, D.L. D.C. Louise, S. Tanaka, and J.C. Reed. 1992. Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the bcl-2 oncoprotein. Biochim. Biophys. Acta. 1132:109-113.
    • (1992) Biochim. Biophys. Acta , vol.1132 , pp. 109-113
    • Cazals-Hatem, D.L.1    Louise, D.C.2    Tanaka, S.3    Reed, J.C.4
  • 20
    • 0001851858 scopus 로고
    • Number and evolutionary conservation of α and β-tubulin and cytoplasmatic β- and γ-actin genes using specific cloned cDNA
    • Cleveland, D.W., M.A. Lobata, R.J. McDonald, N.J. Cowan, W.J. Rutter, and M.W. Kischner. 1980. Number and evolutionary conservation of α and β-tubulin and cytoplasmatic β- and γ-actin genes using specific cloned cDNA. Cell. 20:97-105.
    • (1980) Cell , vol.20 , pp. 97-105
    • Cleveland, D.W.1    Lobata, M.A.2    McDonald, R.J.3    Cowan, N.J.4    Rutter, W.J.5    Kischner, M.W.6
  • 21
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with mini extracts, prepared from a small number of cells
    • Schreiber, E., P. Matthias, M.M. Müller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with mini extracts, prepared from a small number of cells. Nucl. Acids Res. 17:6419.
    • (1989) Nucl. Acids Res. , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Müller, M.M.3    Schaffner, W.4
  • 22
    • 0027496935 scopus 로고
    • The p21 cdk interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21 cdk interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 24
    • 0029063745 scopus 로고
    • Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
    • Luo, Y., J. Hurwitz, and J. Massague. 1995. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature (Lond.). 375: 159-161.
    • (1995) Nature (Lond.) , vol.375 , pp. 159-161
    • Luo, Y.1    Hurwitz, J.2    Massague, J.3
  • 25
    • 0027513593 scopus 로고
    • Integrin β1- and β3-mediated endothelial cell migration is triggered through distinct signal mechanisms
    • Leavesley, D.I., M.A. Schwartz, M. Rosenfeld, and D.A. Cheresh. 1993. Integrin β1- and β3-mediated endothelial cell migration is triggered through distinct signal mechanisms. J. Cell Biol. 121:163-170.
    • (1993) J. Cell Biol. , vol.121 , pp. 163-170
    • Leavesley, D.I.1    Schwartz, M.A.2    Rosenfeld, M.3    Cheresh, D.A.4
  • 26
    • 0027451706 scopus 로고
    • The extracellular matrix as a cell survival factor
    • Meredith, J.E., B. Fazeli, and M.A. Schwartz. 1993. The extracellular matrix as a cell survival factor. Mol. Biol. Cell. 4:953-961.
    • (1993) Mol. Biol. Cell. , vol.4 , pp. 953-961
    • Meredith, J.E.1    Fazeli, B.2    Schwartz, M.A.3
  • 27
    • 0028670298 scopus 로고
    • Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
    • Montgomery, A.M.P., R.A. Reisfeld, and D.A. Cheresh. 1994. Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc. Natl. Acad. Sci. USA. 91:8856-8860.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8856-8860
    • Montgomery, A.M.P.1    Reisfeld, R.A.2    Cheresh, D.A.3
  • 28
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S.M., and H. Francis. 1994. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124:619-626.
    • (1994) J. Cell Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 29
    • 0028927484 scopus 로고
    • Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
    • Boudreau, N., C.J. Sympson, Z. Werb, and M.J. Bissel. 1995. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science (Wash. DC). 267:891-893.
    • (1995) Science (Wash. DC) , vol.267 , pp. 891-893
    • Boudreau, N.1    Sympson, C.J.2    Werb, Z.3    Bissel, M.J.4
  • 30
    • 0028983407 scopus 로고
    • The α5β1 integrin supports survival of cells on fibronectin and up-regulates bcl-2 expression
    • Zhang, Z., K. Vouri, J.C. Reed, and E. Rouslahti. 1995. The α5β1 integrin supports survival of cells on fibronectin and up-regulates bcl-2 expression. Proc. Natl. Acad. Sci. USA. 92:6161-6165.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6161-6165
    • Zhang, Z.1    Vouri, K.2    Reed, J.C.3    Rouslahti, E.4
  • 31
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death
    • Oltvai, Z.N., C.L. Millman, and S.J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell. 74:609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Millman, C.L.2    Korsmeyer, S.J.3
  • 32
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax
    • Yin, X.-M., Z.N. Oltvai, S.J. Korsmeyer. 1994. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature (Lond.). 369:321-323.
    • (1994) Nature (Lond.) , vol.369 , pp. 321-323
    • Yin, X.-M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 34
    • 0028981497 scopus 로고
    • An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization
    • Drake, C.J., D.A. Cheresh, C.D. Little. 1995. An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization. J. Cell Sci. 108:2655-2661.
    • (1995) J. Cell Sci. , vol.108 , pp. 2655-2661
    • Drake, C.J.1    Cheresh, D.A.2    Little, C.D.3
  • 36
    • 0005306564 scopus 로고
    • Human endothelial cells synthesize and express an Arg-Gly-Asp-directed receptor involved in attachment to fibrinogen and von Willebrand factor
    • Cheresh, D.A. 1987. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed receptor involved in attachment to fibrinogen and von Willebrand factor. Proc. Natl. Acad. Sci. USA. 84:6471-6475.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 6471-6475
    • Cheresh, D.A.1
  • 40
    • 0028072225 scopus 로고
    • Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells
    • Re, F., A. Zanetti, M. Sironi, N. Polentarutti, L. Lanfrancone, E. Dejana, and F. Colotta. 1994. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J. Cell Biol. 127:537-546.
    • (1994) J. Cell Biol. , vol.127 , pp. 537-546
    • Re, F.1    Zanetti, A.2    Sironi, M.3    Polentarutti, N.4    Lanfrancone, L.5    Dejana, E.6    Colotta, F.7
  • 41
    • 0028179351 scopus 로고
    • αv integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion
    • Schwartz, M.A., and K. Denninghoff. 1994. αv integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion. J. Biol. Chem. 269:11133-11137.
    • (1994) J. Biol. Chem. , vol.269 , pp. 11133-11137
    • Schwartz, M.A.1    Denninghoff, K.2
  • 42
    • 0028954797 scopus 로고
    • Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
    • Miyamoto, S., S.K. Akiyama, and K.M. Yamada. 1995. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science (Wash. DC). 267:883-885.
    • (1995) Science (Wash. DC) , vol.267 , pp. 883-885
    • Miyamoto, S.1    Akiyama, S.K.2    Yamada, K.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.