Integrins and cell proliferation: Regulation of cyclin-dependent kinases via cytoplasmic signaling pathways

Journal of Cell Science

Volumn 114, Issue 14, 2001, Pages 2553-2560

  Schwartz, M A ^a   Assoian, R K ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cell adhesion; Growth control; Signal transduction; Tyrosine kinase

Indexed keywords

CYCLIN DEPENDENT KINASE; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; INTEGRIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; EXTRACELLULAR MATRIX; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION; CELL DIVISION; CYCLIN-DEPENDENT KINASES; CYTOPLASM; HUMANS; INTEGRINS; MAMMALS; SIGNAL TRANSDUCTION;

EID: 0034902905     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (92)

1. Regulation of development and differentiation by the extracellular matrix
2. p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: Involvement of the small GTPase rhoA
3. Cell adhesion regulates ubiquitin-mediated degradation of the platelet derived growth factor β
4. Distinct roles for the adapter protein Shc and focal adhesion kinase in integrin signaling to Erk
5. Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1
6. Platelet derived growth factor receptor β and vascular endothelial growth factor receptor 2 bind to the β3 integrin through its extracellular domain
7. 1 phase
8. Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression
9. Integrin-mediated signal transduction pathways
10. Geometric control of cell life and death
11. Cellular control lies in the balance of forces
12. Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions
13. Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells
14. Reduced expression of (alpha)5(beta)1 integrin prevents spreading-dependent cell proliferation
15. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin linked kinase
16. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector Pak
17. Integrins enhance platelet-derived growth factor (PDGF) dependent responses by altering the signal relay enzymes that are recruited to the PDGF β receptor
18. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
19. Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
20. Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of CHO cells
21. Integrin signaling
22. Multiple ras effector pathways contribute to G(1) cell cycle progression
23. Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth
24. Cardiovascular anomaly, impaired actin bundling and resistance to src-induced transformation in mice lacking p130cas
25. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
26. The structural and mechanical complexity of cell-growth control
27. Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension
28. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
29. Integrin α2β1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the α2 cytoplasmic tail
30. Regulation of tenascin C, a vascular smooth muscle cell survival factor that interacts with the αvβ3 integrin to promote epidermal growth factor receptor phosphorylation and growth
31. Growth-factor-dependent mitogenesis requires two distinct phases of signalling
32. 1
33. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
34. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
35. Signal transduction by integrins: Increased protein tyrosine phosphorylation caused by integrin clustering
36. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors
37. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)
38. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
39. An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression
40. Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression
41. Cell anchorage permits efficient signal transduction between ras and its downstream kinases
42. Malignant astrocytoma cell attachment and migration to various matrix proteins is differentially sensitive to phosphoinositide inhibitors
43. Alternatively spliced EDA segment regulates fibronectin-dependent cell cycle progression and mitogenic signal transduction
44. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown
45. Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: Correlation between late phase activation and mitogenicity
46. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
47. Integrins induce activation of the EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival
48. 1 phase of the cell cycle
49. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
50. Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells
51. INK4a: Induction of anoikis via upregulation of the α5β1 fibronectin receptor
52. Integrin α1β1 mediates a unique collagen-dependent proliferation pathway in vivo
53. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression
54. The extracellular matrix dynamically regulates smooth muscle cell responsiveness to PDGF
55. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
56. Activation of the MAP kinase pathway by growth factors requires integrin-mediated cell adhesion
57. Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase
58. 1 phase cell cycle machinery
59. α5β1 integrin controls cyclin D1 expression by sustaining mitogen activated protein kinase activity in growth factor treated cells
60. Fibroblast quiescence and the disruption of ERK signaling in mechanically unloaded collagen matrices
61. Fibronectin and its receptors
62. Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal
63. NF-κB mediates αvβ3 integrin-induced cell survival
64. αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF
65. Bidirectional signaling between the cytoskeleton and integrins
66. Integrins, oncogenes and anchorage independence
67. αv integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion
68. Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin α5β1, independent of cell shape
69. Integrins: Emerging paradigms of signal transduction
70. Control of cell cycle progression by fibronectin matrix architecture
71. Integrin receptor mediated mobilization of intranuclear calcium in rat osteoclasts
72. 1 phase progression
73. Integrin-mediated signaling events in human endothelial cells
74. Role of integrins in cellular responses to mechanical stress and adhesion
75. Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
76. Signal regulated activation of serum response factor is mediated by changes in actin dynamics
77. Anchorage and growth regulation in normal and virus-transformed cells
78. Fibronectin receptor modulates cyclin-dependent kinase activity
79. Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts
80. Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle
81. The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate
82. Integrins and cancer
83. Integrin alpha 5 beta 1 expression negatively regulates cell growth: Reversal by attachment to fibronectin
84. Association of insulin receptor substrate-1 with integrins
85. The adapter protein Shc couples a class of integrins to the control of cell cycle progression
86. A requirement for caveolin-1 and associated kinase fyn in integrin-dependent signaling and anchorage-dependent cell growth
87. 1 progression through the independent regulation of cyclin D1 and p27
88. The retinoblastoma protein and cell cycle control
89. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain
90. Regulation of the cell cycle by focal adhesion kinase
91. The effect of extracellular matrix proteins on porcine smooth muscle cell insulin like growth factor (IGF) binding protein-5 synthesis and responsiveness to IGF-I
92. Collagen receptor control of epithelial morphogenesis and cell cycle progression