Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells

Molecular Biology of the Cell

Volumn 12, Issue 10, 2001, Pages 3087-3094

  Flusberg, D A ^a   Numaguchi, Y ^a   Ingber, D E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOCHALASIN D; CYTOSKELETON PROTEIN; FIBRONECTIN; NOCODAZOLE; PROTEIN BCL 2; PROTEIN KINASE; TUBULIN;

ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CAPILLARY ENDOTHELIUM; CELL SHAPE; CELL SURVIVAL; CONTROLLED STUDY; CYTOSKELETON; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; MICROFILAMENT; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 0035163237     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.10.3087     Document Type: Article

References (63)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Matrix attachment regulates Fas-induced apoptosis in endothelial cells. A role for c-Flip and implications for anoikis
3. Integin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
4. Focal adhesions, contractility, and signaling
5. Regulation of cell death protease caspase-9 by phosphorylation
6. Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase
7. Geometric control of cell life and death
8. Micropatterned surfaces for control of cell shape, position, and function
9. Proteases to die for
10. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
11. Phosphoinositide-3-OH kinase-dependent integrin-linked kinase
12. Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis
13. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
14. Mechanisms and consequences of activation of protein kinase B/Akt
15. Toxin-induced activation of Rho GTP-binding protein increases bcl-2 expression and influences mitochondrial homeostasis
16. Disruption of epithelial cell-matrix interactions induces apoptosis
17. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
18. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
19. Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway
20. Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling
21. Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation, and subcellular localization
22. Bcl2 is the guardian of microtubule integrity
23. Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension
24. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis
25. Fibronectin controls capillary endothelial cell growth by modulating cell shape
26. Cellular tensegrity: Defining new rules of biological design that govern the cytoskeleton
27. Basement membrane as a spatial organizer of polarized epithelia
28. Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis
29. Cleavage of actin by interleukin 1beta-converting enzyme to reverse DNase I inhibition
30. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
31. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
32. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase B/Akt cellular survival pathway
33. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin domain
34. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
35. Degradation of focal adhesion proteins during nocodazole-induced apoptosis in rat-1 cells
36. F-actin as a functional target for retro-retinoids: A potential role in anhydroretinol-triggered cell death
37. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
38. The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process, and microfilament assembly
39. The extracellular matrix as a cell survival factor
40. Activation of a PP2A-like phosphatase and dephosphorylation of tau protein characterize onset of the execution phase of apoptosis
41. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
42. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
43. Vascular endothelial growth factor-stimulated actin reorganization, and migration of endothelial cells is regulated via the serine/threonine kinase Akt
44. NF-kappaB activation by tumor necrosis factor requires the Akt serine-threonine kinase
45. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
46. Endothelial cell apoptosis in capillary network remodeling
47. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein
48. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells
49. NF-kB is a target of AKT in anti-apoptotic PDGF signaling
50. Involvement of FADD and caspase-8 signaling in detachment-induced apoptosis
51. Cytochalasin D treatment triggers premature apoptosis of insect ovarian follicle and nurse cells
52. Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha5beta1, independent of cell shape
53. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
54. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis
55. P.T.E.N. modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,trisphosphate and Akt/protein kinase B. signaling pathway
56. Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism
57. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
58. The beta4 integrin subunit rescues A431 cells from apoptosis through a PI3K/Akt kinase signaling pathway
59. Mechanotransduction across the cell surface and through the cytoskeleton
60. Microfilament depletion and circumvention of multiple drug resistance by sphinxolides
61. The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression
62. Akt regulates cell survival, and apoptosis at a postmitochondrial level
63. Phosphorylation and regulation of Raf by Akt (protein kinase B)