메뉴 건너뛰기




Volumn 45, Issue 2, 2002, Pages 73-85

Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors

Author keywords

Cell death; DNA damage repair; PARP inhibitors; Poly(ADP ribose) polymerase (PARP)

Indexed keywords

ALKYLATING AGENT; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OXYGEN RADICAL;

EID: 0036447366     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2001.0935     Document Type: Article
Times cited : (145)

References (160)
  • 1
    • 0035281786 scopus 로고    scopus 로고
    • The world according to PARP
    • Smith S. The world according to PARP. Trends Biochem Sci 2001; 26: 174-9.
    • (2001) Trends Biochem Sci , vol.26 , pp. 174-179
    • Smith, S.1
  • 2
    • 0035796025 scopus 로고    scopus 로고
    • Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death
    • Herceg Z, Wang ZQ. Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res 2001; 477: 97-110.
    • (2001) Mutat Res , vol.477 , pp. 97-110
    • Herceg, Z.1    Wang, Z.Q.2
  • 3
    • 0034985121 scopus 로고    scopus 로고
    • A cellular survival switch: Poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription
    • Ziegler M, Oei SL. A cellular survival switch: Poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription. Bioessays 2001; 23: 543-8.
    • (2001) Bioessays , vol.23 , pp. 543-548
    • Ziegler, M.1    Oei, S.L.2
  • 5
    • 0034733928 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1: What have we learned from the deficient mouse model?
    • Shall S, de Murcia G. Poly(ADP-ribose) polymerase-1: What have we learned from the deficient mouse model? Mutat Res 2000; 460: 1-15.
    • (2000) Mutat Res , vol.460 , pp. 1-15
    • Shall, S.1    De Murcia, G.2
  • 6
    • 0033198919 scopus 로고    scopus 로고
    • Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
    • D'Amours D, Desnoyers S, D'Silva I, Poirier GG. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 1999; 342: 249-68.
    • (1999) Biochem J , vol.342 , pp. 249-268
    • D'Amours, D.1    Desnoyers, S.2    D'Silva, I.3    Poirier, G.G.4
  • 7
    • 0032553473 scopus 로고    scopus 로고
    • Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
    • Smith S, Giriat I, Schmitt A, de Lange T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 1998; 282: 1484-7.
    • (1998) Science , vol.282 , pp. 1484-1487
    • Smith, S.1    Giriat, I.2    Schmitt, A.3    De Lange, T.4
  • 9
    • 0034731455 scopus 로고    scopus 로고
    • Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins
    • Pleschke JM, Kleczkowska HE, Strohm M, Althaus FR. Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J Biol Chem 2000; 275: 40974-80.
    • (2000) J Biol Chem , vol.275 , pp. 40974-40980
    • Pleschke, J.M.1    Kleczkowska, H.E.2    Strohm, M.3    Althaus, F.R.4
  • 11
    • 0035815662 scopus 로고    scopus 로고
    • A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA structure and expression of the mouse PARP-2 gene
    • Ame JC, Schreiber V, Fraulob V, Dolle P, de Murcia G, Niedergang CP. A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA structure and expression of the mouse PARP-2 gene. J Biol Chem 2001; 276: 11092-9.
    • (2001) J Biol Chem , vol.276 , pp. 11092-11099
    • Ame, J.C.1    Schreiber, V.2    Fraulob, V.3    Dolle, P.4    De Murcia, G.5    Niedergang, C.P.6
  • 12
    • 0033135769 scopus 로고    scopus 로고
    • A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues
    • Johansson M. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. Genomics 1999; 57: 442-5.
    • (1999) Genomics , vol.57 , pp. 442-445
    • Johansson, M.1
  • 13
    • 0033230709 scopus 로고    scopus 로고
    • Discovering new ADP-ribose polymer cycles: Protecting the genome and more
    • Jacobson MK, Jacobson EL. Discovering new ADP-ribose polymer cycles: Protecting the genome and more. Trends Biochem Sci 1999; 24: 415-7.
    • (1999) Trends Biochem Sci , vol.24 , pp. 415-417
    • Jacobson, M.K.1    Jacobson, E.L.2
  • 15
    • 0021997074 scopus 로고
    • Poly(ADP-ribose) in the cellular response to DNA damage
    • Berger NA. Poly(ADP-ribose) in the cellular response to DNA damage. Radiat Res 1985; 101: 4-15.
    • (1985) Radiat Res , vol.101 , pp. 4-15
    • Berger, N.A.1
  • 16
    • 0033003004 scopus 로고    scopus 로고
    • Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis
    • Herceg Z, Wang ZQ. Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Mol Cell Biol 1999; 19: 5124-33.
    • (1999) Mol Cell Biol , vol.19 , pp. 5124-5133
    • Herceg, Z.1    Wang, Z.Q.2
  • 17
    • 0034685885 scopus 로고    scopus 로고
    • Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks
    • Sallmann FR, Vodenicharov MD, Wang ZQ, Poirier GG. Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks. J Biol Chem 2000; 275: 15504-11.
    • (2000) J Biol Chem , vol.275 , pp. 15504-15511
    • Sallmann, F.R.1    Vodenicharov, M.D.2    Wang, Z.Q.3    Poirier, G.G.4
  • 18
    • 0034651242 scopus 로고    scopus 로고
    • The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines
    • Schroeijers AB et al. The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines. Cancer Res 2000; 60: 1104-10.
    • (2000) Cancer Res , vol.60 , pp. 1104-1110
    • Schroeijers, A.B.1
  • 19
    • 0034687248 scopus 로고    scopus 로고
    • Tankyrase promotes telomere elongation in human cells
    • Smith S, de Lange T. Tankyrase promotes telomere elongation in human cells. Curr Biol 2000; 10: 1299-302.
    • (2000) Curr Biol , vol.10 , pp. 1299-1302
    • Smith, S.1    De Lange, T.2
  • 20
    • 0029080684 scopus 로고
    • The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy
    • Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH. The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy. Biochimie 1995; 77: 408-22.
    • (1995) Biochimie , vol.77 , pp. 408-422
    • Griffin, R.J.1    Curtin, N.J.2    Newell, D.R.3    Golding, B.T.4    Durkacz, B.W.5    Calvert, A.H.6
  • 21
    • 0022499703 scopus 로고
    • Disturbances in DNA precursor metabolism associated with exposure to an inhibitor of poly(ADP-ribose) synthetase
    • Milam KM, Thomas GH, Cleaver JE. Disturbances in DNA precursor metabolism associated with exposure to an inhibitor of poly(ADP-ribose) synthetase. Exp Cell Res 1986; 165: 260-8.
    • (1986) Exp Cell Res , vol.165 , pp. 260-268
    • Milam, K.M.1    Thomas, G.H.2    Cleaver, J.E.3
  • 22
    • 0022352457 scopus 로고
    • Specificity of inhibitors of poly(ADP-ribose) synthesis. Effects on nucleotide metabolism in cultured cells
    • Hunting DJ, Gowans BJ, Henderson JF. Specificity of inhibitors of poly(ADP-ribose) synthesis. Effects on nucleotide metabolism in cultured cells. Mol Pharmacol 1985; 28: 200-6.
    • (1985) Mol Pharmacol , vol.28 , pp. 200-206
    • Hunting, D.J.1    Gowans, B.J.2    Henderson, J.F.3
  • 23
    • 0028793846 scopus 로고
    • Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)
    • Griffin RJ et al. Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). Anticancer Drug Des 1995; 10: 507-14.
    • (1995) Anticancer Drug Des , vol.10 , pp. 507-514
    • Griffin, R.J.1
  • 26
    • 0028572388 scopus 로고
    • Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells
    • Weltin D, Marchal J, Dufour P, Potworowski E, Oth D, Bischoff P. Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. Oncol Res 1994; 6: 399-403.
    • (1994) Oncol Res , vol.6 , pp. 399-403
    • Weltin, D.1    Marchal, J.2    Dufour, P.3    Potworowski, E.4    Oth, D.5    Bischoff, P.6
  • 27
    • 0000102949 scopus 로고
    • Poly(ADP-ribose) polymerase: A molecular nick-sensor
    • De Murcia G, Menissier de Murcia J. Poly(ADP-ribose) polymerase: A molecular nick-sensor. Trends Biochem Sci 1994; 19: 172-6.
    • (1994) Trends Biochem Sci , vol.19 , pp. 172-176
    • De Murcia, G.1    Menissier De Murcia, J.2
  • 28
    • 0028826231 scopus 로고
    • Potentiation of temozolomide-induced cytotoxicity: A comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors
    • Boulton S, Pemberton LC, Porteous JK, Curtin NJ, Griffin RJ, Golding BT, Durkacz BW. Potentiation of temozolomide-induced cytotoxicity: A comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors. Br J Cancer 1995; 72: 849-56.
    • (1995) Br J Cancer , vol.72 , pp. 849-856
    • Boulton, S.1    Pemberton, L.C.2    Porteous, J.K.3    Curtin, N.J.4    Griffin, R.J.5    Golding, B.T.6    Durkacz, B.W.7
  • 30
    • 0029662166 scopus 로고    scopus 로고
    • 3-Aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity
    • Wedge SR, Porteous JK, Newlands ES. 3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity. Br J Cancer 1996; 74: 1030-6.
    • (1996) Br J Cancer , vol.74 , pp. 1030-1036
    • Wedge, S.R.1    Porteous, J.K.2    Newlands, E.S.3
  • 31
    • 0040984333 scopus 로고    scopus 로고
    • Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
    • De Murcia JM et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA 1997; 94: 7303-7.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7303-7307
    • De Murcia, J.M.1
  • 32
    • 0030611436 scopus 로고    scopus 로고
    • 6-alkylguanine DNA-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide
    • 6-alkylguanine DNA-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide. Mol Pharmacol 1997; 52: 249-58.
    • (1997) Mol Pharmacol , vol.52 , pp. 249-258
    • Tentori, L.1    Orlando, L.2    Lacal, P.M.3
  • 33
    • 0031863682 scopus 로고    scopus 로고
    • Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with an inhibitor of poly(ADP-ribose) polymerase
    • Tentori L, Lacal PM, Benincasa E, Franco D, Faraoni I, Bonmassar E, Graziani G. Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with an inhibitor of poly(ADP-ribose) polymerase. J Pharmacol Exp Ther 1998; 285: 884-93.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 884-893
    • Tentori, L.1    Lacal, P.M.2    Benincasa, E.3    Franco, D.4    Faraoni, I.5    Bonmassar, E.6    Graziani, G.7
  • 34
    • 0032587580 scopus 로고    scopus 로고
    • Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds
    • Tentori L, Turriziani M, Franco D, Serafino A, Levati L, Roy R, Bonmassar E, Graziani G. Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds. Leukemia 1999; 13: 901-9.
    • (1999) Leukemia , vol.13 , pp. 901-909
    • Tentori, L.1    Turriziani, M.2    Franco, D.3    Serafino, A.4    Levati, L.5    Roy, R.6    Bonmassar, E.7    Graziani, G.8
  • 35
    • 0032938458 scopus 로고    scopus 로고
    • Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage
    • Boulton S, Kyle S, Durkacz BW. Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage. Carcinogenesis 1999; 20: 199-203.
    • (1999) Carcinogenesis , vol.20 , pp. 199-203
    • Boulton, S.1    Kyle, S.2    Durkacz, B.W.3
  • 36
    • 0032694518 scopus 로고    scopus 로고
    • Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents
    • Liu L, Taverna P, Whitacre CM, Chatterjee S, Gerson SL. Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents. Clin Cancer Res 1999; 5: 2908-17.
    • (1999) Clin Cancer Res , vol.5 , pp. 2908-2917
    • Liu, L.1    Taverna, P.2    Whitacre, C.M.3    Chatterjee, S.4    Gerson, S.L.5
  • 38
    • 0034743378 scopus 로고    scopus 로고
    • Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components
    • Tentori L, Portarena I, Vernole P, De Fabritiis P, Madaio R, Balduzzi A, Roy R, Bonmassar E, Graziani G. Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components. Cancer Chemother Pharmacol 2001; 47: 361-9.
    • (2001) Cancer Chemother Pharmacol , vol.47 , pp. 361-369
    • Tentori, L.1    Portarena, I.2    Vernole, P.3    De Fabritiis, P.4    Madaio, R.5    Balduzzi, A.6    Roy, R.7    Bonmassar, E.8    Graziani, G.9
  • 39
    • 0035009692 scopus 로고    scopus 로고
    • Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells
    • Tentori L, Portarena I, Bonmassar E, Graziani G. Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells. Cell Death Differ 2001; 8: 457-69.
    • (2001) Cell Death Differ , vol.8 , pp. 457-469
    • Tentori, L.1    Portarena, I.2    Bonmassar, E.3    Graziani, G.4
  • 40
    • 0027412686 scopus 로고
    • NAD(+)-dependent repair of damaged DNA by human cell extracts
    • Satoh MS, Poirier GG, Lindahl T. NAD(+)-dependent repair of damaged DNA by human cell extracts. J Biol Chem 1993; 268: 5480-7.
    • (1993) J Biol Chem , vol.268 , pp. 5480-5487
    • Satoh, M.S.1    Poirier, G.G.2    Lindahl, T.3
  • 41
    • 0029842307 scopus 로고    scopus 로고
    • Reconstitution of DNA base excision-repair with purified human proteins: Interaction between DNA polymerase beta and the XRCC1 protein
    • Kubota Y, Nash RA, Klungland A, Schar P, Barnes DE, Lindahl T. Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. EMBO J 1996; 15: 6662-70.
    • (1996) EMBO J , vol.15 , pp. 6662-6670
    • Kubota, Y.1    Nash, R.A.2    Klungland, A.3    Schar, P.4    Barnes, D.E.5    Lindahl, T.6
  • 42
    • 0031844311 scopus 로고    scopus 로고
    • XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
    • Masson M, Niedergang C, Schreiber V, Muller S, Menissier-de Murcia J, de Murcia G. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol 1998; 18: 3563-71.
    • (1998) Mol Cell Biol , vol.18 , pp. 3563-3571
    • Masson, M.1    Niedergang, C.2    Schreiber, V.3    Muller, S.4    Menissierde Murcia, J.5    De Murcia, G.6
  • 44
    • 0034667921 scopus 로고    scopus 로고
    • Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1
    • Vodenicharov MD, Sallmann FR, Satoh MS, Poirier GG. Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1. Nucleic Acids Res 2000; 28: 3887-96.
    • (2000) Nucleic Acids Res , vol.28 , pp. 3887-3896
    • Vodenicharov, M.D.1    Sallmann, F.R.2    Satoh, M.S.3    Poirier, G.G.4
  • 45
    • 0031762817 scopus 로고    scopus 로고
    • Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064
    • Bowman KJ, White A, Golding BT, Griffin RJ, Curtin NJ. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br J Cancer 1998; 78: 1269-77.
    • (1998) Br J Cancer , vol.78 , pp. 1269-1277
    • Bowman, K.J.1    White, A.2    Golding, B.T.3    Griffin, R.J.4    Curtin, N.J.5
  • 46
    • 0033941729 scopus 로고    scopus 로고
    • Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly (adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines
    • Delaney CA, Wang LZ, Kyle S, White AW, Calvert AH, Curtin NJ, Durkacz BW, Hostomsky Z, Newell DR. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly (adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res 2000; 6: 2860-7.
    • (2000) Clin Cancer Res , vol.6 , pp. 2860-2867
    • Delaney, C.A.1    Wang, L.Z.2    Kyle, S.3    White, A.W.4    Calvert, A.H.5    Curtin, N.J.6    Durkacz, B.W.7    Hostomsky, Z.8    Newell, D.R.9
  • 47
    • 0032855728 scopus 로고    scopus 로고
    • Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal brain tumor group
    • Yung WK, Prados MD, Yaya-Tur R et al. Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal brain tumor group. J Clin Oncol 1999; 17: 2762-71.
    • (1999) J Clin Oncol , vol.17 , pp. 2762-2771
    • Yung, W.K.1    Prados, M.D.2    Yaya-Tur, R.3
  • 48
    • 0033989205 scopus 로고    scopus 로고
    • Randomized phase III study of temozolomide versus decarbazine in the treatment of patients with advanced metastatic malignant melanoma
    • Middleton MR, Grob JJ, Aaronson N et al. Randomized phase III study of temozolomide versus decarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol 2000; 18: 158-66.
    • (2000) J Clin Oncol , vol.18 , pp. 158-166
    • Middleton, M.R.1    Grob, J.J.2    Aaronson, N.3
  • 49
    • 0034034511 scopus 로고    scopus 로고
    • Health-related quality of life in patients treated with temozolomide versus procarbazine for recurrent glioblastoma multiforme
    • Osoba D, Brada M, Yung WK, Prados M. Health-related quality of life in patients treated with temozolomide versus procarbazine for recurrent glioblastoma multiforme. J Clin Oncol 2000; 18: 1481-91.
    • (2000) J Clin Oncol , vol.18 , pp. 1481-1491
    • Osoba, D.1    Brada, M.2    Yung, W.K.3    Prados, M.4
  • 50
    • 0034607260 scopus 로고    scopus 로고
    • Salvage therapy with temozolomide in an immunocompetent patient with primary brain lymphoma
    • Reni M, Ferreri AJM, Landoni C, Villa E. Salvage therapy with temozolomide in an immunocompetent patient with primary brain lymphoma. J Natl Cancer Inst 2000; 92: 575-6.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 575-576
    • Reni, M.1    Ferreri, A.J.M.2    Landoni, C.3    Villa, E.4
  • 54
    • 0027363208 scopus 로고
    • Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer
    • Han HJ, Yanagisawa A, Kato Y, Park JG, Nakamura Y. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 1993; 53: 5087-9.
    • (1993) Cancer Res , vol.53 , pp. 5087-5089
    • Han, H.J.1    Yanagisawa, A.2    Kato, Y.3    Park, J.G.4    Nakamura, Y.5
  • 56
    • 0028284887 scopus 로고
    • Genetic instability of microsatellite sequences in many non-small cell lung carcinomas
    • Shridhar V, Siegfried J, Hunt J, del Mar Alonso M, Smith DI. Genetic instability of microsatellite sequences in many non-small cell lung carcinomas. Cancer Res 1994; 54: 2084-7.
    • (1994) Cancer Res , vol.54 , pp. 2084-2087
    • Shridhar, V.1    Siegfried, J.2    Hunt, J.3    Del Mar Alonso, M.4    Smith, D.I.5
  • 57
    • 0028362315 scopus 로고
    • Instability of short tandem repeats (microsatellites) in human cancers
    • Wooster R et al. Instability of short tandem repeats (microsatellites) in human cancers. Nat Genet 1994; 6: 152-6.
    • (1994) Nat Genet , vol.6 , pp. 152-156
    • Wooster, R.1
  • 58
    • 10544255085 scopus 로고    scopus 로고
    • Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype
    • Ben-Yehuda D et al. Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood 1996; 88: 4296-303.
    • (1996) Blood , vol.88 , pp. 4296-4303
    • Ben-Yehuda, D.1
  • 59
    • 0033215386 scopus 로고    scopus 로고
    • Mutator phenotype in human hematopoietic neoplasms and its association with deletions disabling DNA repair genes and bcl-2 rearrangements
    • Indraccolo S et al. Mutator phenotype in human hematopoietic neoplasms and its association with deletions disabling DNA repair genes and bcl-2 rearrangements. Blood 1999; 94: 2424-32.
    • (1999) Blood , vol.94 , pp. 2424-2432
    • Indraccolo, S.1
  • 60
    • 0031906084 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in drug resistance
    • Fink D, Aebi S, Howell SB. The role of DNA mismatch repair in drug resistance. Clin Cancer Res 1998; 4: 1-6.
    • (1998) Clin Cancer Res , vol.4 , pp. 1-6
    • Fink, D.1    Aebi, S.2    Howell, S.B.3
  • 61
    • 0037085761 scopus 로고    scopus 로고
    • Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematological malignancy at the CNS site
    • in press
    • Tentori L, Leonetti C, Scarsella M, D'Amati G, Portarena I, Zupi G, Bonmassar E, Graziani G. Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematological malignancy at the CNS site. Blood 2002, in press.
    • (2002) Blood
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3    D'Amati, G.4    Portarena, I.5    Zupi, G.6    Bonmassar, E.7    Graziani, G.8
  • 62
    • 0029868460 scopus 로고    scopus 로고
    • The in vitro methylation of DNA by a minor groove binding methyl sulfonate ester
    • Encell L, Shuker DE, Foiles PG, Gold B. The in vitro methylation of DNA by a minor groove binding methyl sulfonate ester. Chem Res Toxicol 1996; 9: 563-7.
    • (1996) Chem Res Toxicol , vol.9 , pp. 563-567
    • Encell, L.1    Shuker, D.E.2    Foiles, P.G.3    Gold, B.4
  • 63
    • 0033603438 scopus 로고    scopus 로고
    • Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent
    • Kelly JD et al. Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent. J Biol Chem 1999; 274: 18327-34.
    • (1999) J Biol Chem , vol.274 , pp. 18327-18334
    • Kelly, J.D.1
  • 64
    • 0033880685 scopus 로고    scopus 로고
    • Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells
    • Tentori L et al. Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells. Leukemia 2000; 14: 1451-9.
    • (2000) Leukemia , vol.14 , pp. 1451-1459
    • Tentori, L.1
  • 65
    • 0034897316 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester
    • Tentori L, Balduzzi A, Portarena I, Levati L, Vernole P, Gold B, Bonmassar E, Graziani G. Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester. Cell Death Differ 2001; 8: 817-28.
    • (2001) Cell Death Differ , vol.8 , pp. 817-828
    • Tentori, L.1    Balduzzi, A.2    Portarena, I.3    Levati, L.4    Vernole, P.5    Gold, B.6    Bonmassar, E.7    Graziani, G.8
  • 66
    • 0035137364 scopus 로고    scopus 로고
    • Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro
    • Bowman KJ, Newell DR, Calvert AH, Curtin NJ. Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro. Br J Cancer 2001; 84: 106-12.
    • (2001) Br J Cancer , vol.84 , pp. 106-112
    • Bowman, K.J.1    Newell, D.R.2    Calvert, A.H.3    Curtin, N.J.4
  • 67
    • 0031474597 scopus 로고    scopus 로고
    • Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose) polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells
    • Weltin D, Holl V, Hyun JW, Dufour P, Marchal J, Bischoff P. Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose) polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells. Int J Radiat Biol 1997; 72: 685-92.
    • (1997) Int J Radiat Biol , vol.72 , pp. 685-692
    • Weltin, D.1    Holl, V.2    Hyun, J.W.3    Dufour, P.4    Marchal, J.5    Bischoff, P.6
  • 69
    • 0035174362 scopus 로고    scopus 로고
    • Regulation of bleomycin-induced DNA breakage and chromatin structure in lung endothelial cells by integrins and poly(ADP-ribose) polymerase
    • Jones CB, McIntosh J, Huang H, Graytock A, Hoyt DG. Regulation of bleomycin-induced DNA breakage and chromatin structure in lung endothelial cells by integrins and poly(ADP-ribose) polymerase. Mol Pharmacol 2001; 59: 69-75.
    • (2001) Mol Pharmacol , vol.59 , pp. 69-75
    • Jones, C.B.1    McIntosh, J.2    Huang, H.3    Graytock, A.4    Hoyt, D.G.5
  • 72
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33: 787-91.
    • (1997) Eur J Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 73
    • 0033852802 scopus 로고    scopus 로고
    • Clinical applications of telomerase in cancer treatment
    • Faraoni I, Bonmassar E, Graziani G. Clinical applications of telomerase in cancer treatment. Drug Resist Update 2000; 3: 161-70.
    • (2000) Drug Resist Update , vol.3 , pp. 161-170
    • Faraoni, I.1    Bonmassar, E.2    Graziani, G.3
  • 74
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • Van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997; 385: 740-3.
    • (1997) Nature , vol.385 , pp. 740-743
    • Van Steensel, B.1    De Lange, T.2
  • 75
    • 0030842946 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
    • Eliasson MJ et al. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 1997; 3: 1089-95.
    • (1997) Nat Med , vol.3 , pp. 1089-1095
    • Eliasson, M.J.1
  • 77
    • 17544364526 scopus 로고    scopus 로고
    • Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase
    • Whalen MJ et al. Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 1999; 19: 835-42.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 835-842
    • Whalen, M.J.1
  • 78
    • 0032514225 scopus 로고    scopus 로고
    • Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury
    • Zingarelli B, Salzman AL, Szabo C. Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res 1998; 83: 85-94.
    • (1998) Circ Res , vol.83 , pp. 85-94
    • Zingarelli, B.1    Salzman, A.L.2    Szabo, C.3
  • 79
    • 13044270976 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
    • Masutani M et al. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. Proc Natl Acad Sci USA 1999; 96: 2301-4.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2301-2304
    • Masutani, M.1
  • 80
    • 0033011114 scopus 로고    scopus 로고
    • Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin
    • Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, Wagner EF, Kolb H. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin. Nat Med 1999; 5: 314-9.
    • (1999) Nat Med , vol.5 , pp. 314-319
    • Burkart, V.1    Wang, Z.Q.2    Radons, J.3    Heller, B.4    Herceg, Z.5    Stingl, L.6    Wagner, E.F.7    Kolb, H.8
  • 83
    • 0025063609 scopus 로고
    • Excitatory amino acid neurotoxicity and neurodegenerative disease
    • Meldrum B, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 1990; 11: 379-87.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 379-387
    • Meldrum, B.1    Garthwaite, J.2
  • 84
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994; 330: 613-22.
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 86
    • 0028294246 scopus 로고
    • Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity
    • Zhang J, Dawson VL, Dawson TM, Snyder SH. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 1994; 263: 687-9.
    • (1994) Science , vol.263 , pp. 687-689
    • Zhang, J.1    Dawson, V.L.2    Dawson, T.M.3    Snyder, S.H.4
  • 87
    • 0029100217 scopus 로고
    • Poly(ADP-ribose) synthetase activation: An early indicator of neurotoxic DNA damage
    • Zhang J, Pieper A, Snyder SH. Poly(ADP-ribose) synthetase activation: An early indicator of neurotoxic DNA damage. J Neurochem 1995; 65: 1411-4.
    • (1995) J Neurochem , vol.65 , pp. 1411-1414
    • Zhang, J.1    Pieper, A.2    Snyder, S.H.3
  • 88
    • 12944332086 scopus 로고    scopus 로고
    • Poly (ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission
    • Pieper AA et al. Poly (ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission. Proc Natl Acad Sci USA 2000; 97: 1845-50.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1845-1850
    • Pieper, A.A.1
  • 90
    • 0031946532 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase: Reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation
    • Lo EH, Bosque-Hamilton P, Meng W. Inhibition of poly(ADP-ribose) polymerase: Reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation. Stroke 1998; 29: 830-6.
    • (1998) Stroke , vol.29 , pp. 830-836
    • Lo, E.H.1    Bosque-Hamilton, P.2    Meng, W.3
  • 93
    • 0033594743 scopus 로고    scopus 로고
    • Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia
    • Takahashi K, Pieper AA, Croul SE, Zhang J, Snyder SH, Greenberg JH. Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. Brain Res 1999; 829: 46-54.
    • (1999) Brain Res , vol.829 , pp. 46-54
    • Takahashi, K.1    Pieper, A.A.2    Croul, S.E.3    Zhang, J.4    Snyder, S.H.5    Greenberg, J.H.6
  • 94
    • 0033551597 scopus 로고    scopus 로고
    • The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase
    • Takahashi K, Greenberg JH. The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase. Neuroreport 1999; 10: 2017-22.
    • (1999) Neuroreport , vol.10 , pp. 2017-2022
    • Takahashi, K.1    Greenberg, J.H.2
  • 95
    • 0035850884 scopus 로고    scopus 로고
    • Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment
    • Ding Y, Zhou Y, Lai Q, Li J, Gordon V, Diaz FG. Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment. Brain Res 2001; 915: 210-7.
    • (2001) Brain Res , vol.915 , pp. 210-217
    • Ding, Y.1    Zhou, Y.2    Lai, Q.3    Li, J.4    Gordon, V.5    Diaz, F.G.6
  • 99
    • 0034575192 scopus 로고    scopus 로고
    • Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: A preliminary report
    • Whalen MJ et al. Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: A preliminary report. Acta Neurochir Suppl 2000; 76: 61-4.
    • (2000) Acta Neurochir Suppl , vol.76 , pp. 61-64
    • Whalen, M.J.1
  • 101
    • 0034903405 scopus 로고    scopus 로고
    • Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection
    • Weise J, Isenmann S, Bahr M. Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection. Cell Death Differ 2001; 8: 801-7.
    • (2001) Cell Death Differ , vol.8 , pp. 801-807
    • Weise, J.1    Isenmann, S.2    Bahr, M.3
  • 102
    • 0027343340 scopus 로고
    • Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease. Neuropathologic considerations
    • Forno LS, DeLanney LE, Irwin I, Langston JW. Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease. Neuropathologic considerations. Adv Neurol 1993; 60: 600-8.
    • (1993) Adv Neurol , vol.60 , pp. 600-608
    • Forno, L.S.1    DeLanney, L.E.2    Irwin, I.3    Langston, J.W.4
  • 104
    • 0028091176 scopus 로고
    • Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
    • Dexter DT et al.. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann Neurol 1994; 35: 38-44.
    • (1994) Ann Neurol , vol.35 , pp. 38-44
    • Dexter, D.T.1
  • 105
    • 0029687772 scopus 로고    scopus 로고
    • Neurotoxicity and the mechanisms of cell death in Parkinson's disease
    • Schapira AH. Neurotoxicity and the mechanisms of cell death in Parkinson's disease. Adv Neurol 1996; 69: 161-5.
    • (1996) Adv Neurol , vol.69 , pp. 161-165
    • Schapira, A.H.1
  • 106
    • 0029751103 scopus 로고    scopus 로고
    • The etiology of Parkinson's disease with emphasis on the MPTP story
    • Langston JW. The etiology of Parkinson's disease with emphasis on the MPTP story. Neurology 1996; 47 (Suppl. 3): S153-60.
    • (1996) Neurology , vol.47 , Issue.SUPPL. 3
    • Langston, J.W.1
  • 107
    • 0030878073 scopus 로고    scopus 로고
    • Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra
    • Alam ZI, Jenner A, Daniel SE, Lees AJ, Cairns N, Marsden CD, Jenner P, Halliwell B. Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 1997; 69: 1196-203.
    • (1997) J Neurochem , vol.69 , pp. 1196-1203
    • Alam, Z.I.1    Jenner, A.2    Daniel, S.E.3    Lees, A.J.4    Cairns, N.5    Marsden, C.D.6    Jenner, P.7    Halliwell, B.8
  • 108
    • 0028908516 scopus 로고
    • Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons
    • Harris ME, Hensley K, Butterfield DA, Leedle RA, Carney JM. Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons. Exp Neurol 1995; 131: 193-202.
    • (1995) Exp Neurol , vol.131 , pp. 193-202
    • Harris, M.E.1    Hensley, K.2    Butterfield, D.A.3    Leedle, R.A.4    Carney, J.M.5
  • 110
    • 0030155860 scopus 로고    scopus 로고
    • Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease
    • Mark RJ, Blanc EM, Mattson MP. Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease. Mol Neurobiol 1996; 12: 211-24.
    • (1996) Mol Neurobiol , vol.12 , pp. 211-224
    • Mark, R.J.1    Blanc, E.M.2    Mattson, M.P.3
  • 111
    • 0030966546 scopus 로고    scopus 로고
    • Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: Role of the lipid peroxidation product 4-hydroxynonenal
    • Keller JN, Pang Z, Geddes JW, Begley JG, Germeyer A, Waeg G, Mattson MP. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: Role of the lipid peroxidation product 4-hydroxynonenal. J Neurochem 1997; 69: 273-84.
    • (1997) J Neurochem , vol.69 , pp. 273-284
    • Keller, J.N.1    Pang, Z.2    Geddes, J.W.3    Begley, J.G.4    Germeyer, A.5    Waeg, G.6    Mattson, M.P.7
  • 112
    • 0028023944 scopus 로고
    • Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress
    • Yan SD et al. Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress. Proc Natl Acad Sci USA 1994; 91: 7787-91.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7787-7791
    • Yan, S.D.1
  • 113
    • 0032901904 scopus 로고    scopus 로고
    • Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease
    • Love S, Barber R, Wilcock GK. Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease. Brain 1999; 122: 247-53.
    • (1999) Brain , vol.122 , pp. 247-253
    • Love, S.1    Barber, R.2    Wilcock, G.K.3
  • 114
    • 0034666267 scopus 로고    scopus 로고
    • Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
    • Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson SP. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 2000; 20: 6920-6.
    • (2000) J Neurosci , vol.20 , pp. 6920-6926
    • Kruman, I.I.1    Culmsee, C.2    Chan, S.L.3    Kruman, Y.4    Guo, Z.5    Penix, L.6    Mattson, S.P.7
  • 115
    • 0030053864 scopus 로고    scopus 로고
    • Coenzyme nicotinamide adenine dinucleotide: New therapeutic approach for improving dementia of the Alzheimer type
    • Birkmayer JG. Coenzyme nicotinamide adenine dinucleotide: New therapeutic approach for improving dementia of the Alzheimer type. Ann Clin Lab Sci 1996; 26: 1-9.
    • (1996) Ann Clin Lab Sci , vol.26 , pp. 1-9
    • Birkmayer, J.G.1
  • 116
    • 0030903968 scopus 로고    scopus 로고
    • The effect of 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, on ischemia/reperfusion damage in rat retina
    • Lam TT. The effect of 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, on ischemia/reperfusion damage in rat retina. Res Commun Mol Pathol Pharmacol 1997; 95: 241-52.
    • (1997) Res Commun Mol Pathol Pharmacol , vol.95 , pp. 241-252
    • Lam, T.T.1
  • 117
    • 0033823742 scopus 로고    scopus 로고
    • Post-treatment at 12 or 18 hours with 3-aminobenzamide ameliorates retinal ischemia-reperfusion damage
    • Chiang SK, Lam TT. Post-treatment at 12 or 18 hours with 3-aminobenzamide ameliorates retinal ischemia-reperfusion damage. Invest Ophthalmol Vis Sci 2000; 41: 3210-4.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3210-3214
    • Chiang, S.K.1    Lam, T.T.2
  • 118
    • 0031239152 scopus 로고    scopus 로고
    • Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts in vitro
    • Gilad E, Zingarelli B, Salzman AL, Szabo C. Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts in vitro. J Mol Cell Cardiol 1997; 29: 2585-97.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 2585-2597
    • Gilad, E.1    Zingarelli, B.2    Salzman, A.L.3    Szabo, C.4
  • 119
    • 0031020434 scopus 로고    scopus 로고
    • Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle
    • Thiemermann C, Bowes J, Myint FP, Vane JR. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci USA 1997; 94: 679-83.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 679-683
    • Thiemermann, C.1    Bowes, J.2    Myint, F.P.3    Vane, J.R.4
  • 120
    • 0031281259 scopus 로고    scopus 로고
    • Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
    • Zingarelli B, Cuzzocrea S, Zsengeller Z, Salzman AL, Szabo C. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovasc Res 1997; 36: 205-15.
    • (1997) Cardiovasc Res , vol.36 , pp. 205-215
    • Zingarelli, B.1    Cuzzocrea, S.2    Zsengeller, Z.3    Salzman, A.L.4    Szabo, C.5
  • 121
    • 16744367820 scopus 로고    scopus 로고
    • Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig
    • Bowes J, Ruetten H, Martorana PA, Stockhausen H, Thiemermann C. Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig. Eur J Pharmacol 1998; 359: 143-50.
    • (1998) Eur J Pharmacol , vol.359 , pp. 143-150
    • Bowes, J.1    Ruetten, H.2    Martorana, P.A.3    Stockhausen, H.4    Thiemermann, C.5
  • 122
    • 0031874002 scopus 로고    scopus 로고
    • Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: A comparison with radical scavengers
    • Bowes J, Thiemermann C. Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: A comparison with radical scavengers. Br J Pharmacol 1998; 124: 1254-60.
    • (1998) Br J Pharmacol , vol.124 , pp. 1254-1260
    • Bowes, J.1    Thiemermann, C.2
  • 123
    • 0032796943 scopus 로고    scopus 로고
    • An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart
    • Docherty JC, Kuzio B, Silvester JA, Bowes J, Thiemermann C. An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart. Br J Pharmacol 1999; 127: 1518-24.
    • (1999) Br J Pharmacol , vol.127 , pp. 1518-1524
    • Docherty, J.C.1    Kuzio, B.2    Silvester, J.A.3    Bowes, J.4    Thiemermann, C.5
  • 124
    • 0032990891 scopus 로고    scopus 로고
    • Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts
    • Grupp IL, Jackson TM, Hake P, Grupp G, Szabo C. Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts. J Mol Cell Cardiol 1999; 31: 297-303.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 297-303
    • Grupp, I.L.1    Jackson, T.M.2    Hake, P.3    Grupp, G.4    Szabo, C.5
  • 126
    • 0033627868 scopus 로고    scopus 로고
    • Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion of injury
    • Yang Z, Zingarelli B, Szabo C. Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion of injury. Shock 2000; 13: 60-6.
    • (2000) Shock , vol.13 , pp. 60-66
    • Yang, Z.1    Zingarelli, B.2    Szabo, C.3
  • 127
    • 0034987156 scopus 로고    scopus 로고
    • Effect of poly(ADP-ribose) polymers inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system
    • Halmosi R, Berente Z, Osz E, Toth K, Literati-Nagy P, Sumegi B. Effect of poly(ADP-ribose) polymers inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol Pharmacol 2001; 59: 1497-505.
    • (2001) Mol Pharmacol , vol.59 , pp. 1497-1505
    • Halmosi, R.1    Berente, Z.2    Osz, E.3    Toth, K.4    Literati-Nagy, P.5    Sumegi, B.6
  • 128
    • 0034870585 scopus 로고    scopus 로고
    • Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: Long-term morphological and functional consequences
    • Liaudet L, Szabo E, Timashpolsky L, Virag L, Cziraki A, Szabo C. Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: Long-term morphological and functional consequences. Br J Pharmacol 2001; 133: 1424-30.
    • (2001) Br J Pharmacol , vol.133 , pp. 1424-1430
    • Liaudet, L.1    Szabo, E.2    Timashpolsky, L.3    Virag, L.4    Cziraki, A.5    Szabo, C.6
  • 129
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16: 225-60.
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 130
    • 0030000690 scopus 로고    scopus 로고
    • DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
    • Szabo C, Zingarelli B, O'Connor M, Salzman AL. DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA 1996; 93: 1753-8.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1753-1758
    • Szabo, C.1    Zingarelli, B.2    O'Connor, M.3    Salzman, A.L.4
  • 133
    • 0029257151 scopus 로고
    • Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotocin contributes to islet cell DNA damage
    • Kroncke KD, Fehsel K, Sommer A, Rodriguez ML, Kolb-Bachofen V. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotocin contributes to islet cell DNA damage. Biol Chem 1995; 376: 179-85.
    • (1995) Biol Chem , vol.376 , pp. 179-185
    • Kroncke, K.D.1    Fehsel, K.2    Sommer, A.3    Rodriguez, M.L.4    Kolb-Bachofen, V.5
  • 134
    • 0014183930 scopus 로고
    • The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity
    • Schein PS, Cooney DA, Vernon ML. The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity. Cancer Res 1967; 27: 2324-32.
    • (1967) Cancer Res , vol.27 , pp. 2324-2332
    • Schein, P.S.1    Cooney, D.A.2    Vernon, M.L.3
  • 135
    • 0019310901 scopus 로고
    • Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets
    • Yamamoto H, Okamoto H. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun 1980; 95: 474-81.
    • (1980) Biochem Biophys Res Commun , vol.95 , pp. 474-481
    • Yamamoto, H.1    Okamoto, H.2
  • 136
    • 0020315923 scopus 로고
    • Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis
    • Uchigata Y, Yamamoto H, Kawamura A, Okamoto H. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem 1982; 257: 6084-8.
    • (1982) J Biol Chem , vol.257 , pp. 6084-6088
    • Uchigata, Y.1    Yamamoto, H.2    Kawamura, A.3    Okamoto, H.4
  • 137
    • 0021922023 scopus 로고
    • The role of poly(ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet B-cell regeneration
    • Okamoto H. The role of poly(ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet B-cell regeneration. Biomed Biochim Acta 1985; 44: 15-20.
    • (1985) Biomed Biochim Acta , vol.44 , pp. 15-20
    • Okamoto, H.1
  • 138
    • 0029017038 scopus 로고
    • Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
    • Heller B, Wang ZQ, Wanger EF, Radons J, Burkle A, Fehsel K, Burkart V, Kolb H. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem 1995; 270: 11176-80.
    • (1995) J Biol Chem , vol.270 , pp. 11176-11180
    • Heller, B.1    Wang, Z.Q.2    Wanger, E.F.3    Radons, J.4    Burkle, A.5    Fehsel, K.6    Burkart, V.7    Kolb, H.8
  • 139
    • 0035851210 scopus 로고    scopus 로고
    • Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase
    • Soriano FG, Pacher P, Mabley J, Liaudet L, Szabo C. Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 2001; 89: 684-91.
    • (2001) Circ Res , vol.89 , pp. 684-691
    • Soriano, F.G.1    Pacher, P.2    Mabley, J.3    Liaudet, L.4    Szabo, C.5
  • 140
    • 0035136240 scopus 로고    scopus 로고
    • Diabetic endothelial dysfunction: The role of poly(ADP-ribose) polymerase activation
    • Garcia Soriano F et al.. Diabetic endothelial dysfunction: The role of poly(ADP-ribose) polymerase activation. Nat Med 2001; 7: 108-13.
    • (2001) Nat Med , vol.7 , pp. 108-113
    • Garcia Soriano, F.1
  • 143
    • 0035148308 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits
    • Satoh M, Date I, Nakajima M, Takahashi K, Iseda K, Tamiya T, Ohmoto T, Ninomiya Y, Asari S. Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits. Stroke 2001; 32: 225-31.
    • (2001) Stroke , vol.32 , pp. 225-231
    • Satoh, M.1    Date, I.2    Nakajima, M.3    Takahashi, K.4    Iseda, K.5    Tamiya, T.6    Ohmoto, T.7    Ninomiya, Y.8    Asari, S.9
  • 146
    • 0034657984 scopus 로고    scopus 로고
    • The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death
    • Ying W, Swanson RA. The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death. Neuroreport 2000; 11: 1385-8.
    • (2000) Neuroreport , vol.11 , pp. 1385-1388
    • Ying, W.1    Swanson, R.A.2
  • 147
    • 0035834146 scopus 로고    scopus 로고
    • Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death
    • Ying W, Sevigny MB, Chen Y, Swanson RA. Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. Proc Natl Acad Sci USA 2001; 98: 12227-32.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12227-12232
    • Ying, W.1    Sevigny, M.B.2    Chen, Y.3    Swanson, R.A.4
  • 148
    • 0019996840 scopus 로고
    • 3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light
    • Morgan WF, Cleaver JE. 3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light. Mutat Res 1982; 104: 361-6.
    • (1982) Mutat Res , vol.104 , pp. 361-366
    • Morgan, W.F.1    Cleaver, J.E.2
  • 149
    • 0025089237 scopus 로고
    • Potentiation of carcinogen-induced methotrexate resistance and dihydrofolate reductase gene amplification by inhibitors of poly(adenosine diphosphate-ribose) polymerase
    • Burkle A, Heilbronn R, zur Hausen H. Potentiation of carcinogen-induced methotrexate resistance and dihydrofolate reductase gene amplification by inhibitors of poly(adenosine diphosphate-ribose) polymerase. Cancer Res 1990; 50: 5756-60.
    • (1990) Cancer Res , vol.50 , pp. 5756-5760
    • Burkle, A.1    Heilbronn, R.2    Zur Hausen, H.3
  • 150
    • 0026046440 scopus 로고
    • Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation)
    • Waldman AS, Waldman BC. Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation). Nucleic Acids Res 1991; 19: 5943-7.
    • (1991) Nucleic Acids Res , vol.19 , pp. 5943-5947
    • Waldman, A.S.1    Waldman, B.C.2
  • 151
    • 0029000890 scopus 로고
    • A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage
    • Schreiber V, Hunting D, Trucco C, Gowans B, Grunwald D, De Murcia G, De Murcia JM. A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage. Proc Natl Acad Sci USA 1995; 92: 4753-7.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4753-4757
    • Schreiber, V.1    Hunting, D.2    Trucco, C.3    Gowans, B.4    Grunwald, D.5    De Murcia, G.6    De Murcia, J.M.7
  • 152
    • 0029929225 scopus 로고    scopus 로고
    • Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen induced gene amplification in SV40-transformed Chinese hamster cells
    • Kupper JH, Muller M, Burkle A. Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen induced gene amplification in SV40-transformed Chinese hamster cells. Cancer Res 1996; 56: 2715-7.
    • (1996) Cancer Res , vol.56 , pp. 2715-2717
    • Kupper, J.H.1    Muller, M.2    Burkle, A.3
  • 153
    • 0026642041 scopus 로고
    • Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining
    • Ding R, Pommier Y, Kang VH, Smulson M. Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining. J Biol Chem 1992; 267: 12804-12.
    • (1992) J Biol Chem , vol.267 , pp. 12804-12812
    • Ding, R.1    Pommier, Y.2    Kang, V.H.3    Smulson, M.4
  • 154
    • 0028145365 scopus 로고
    • Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: Influences on genomic stability, chromatin organization, and carcinogen cytotoxicity
    • Ding R, Smulson M. Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: Influences on genomic stability, chromatin organization, and carcinogen cytotoxicity. Cancer Res 1994; 54: 4627-34.
    • (1994) Cancer Res , vol.54 , pp. 4627-4634
    • Ding, R.1    Smulson, M.2
  • 155
    • 0036189995 scopus 로고    scopus 로고
    • Apoptotic and cytotoxic effects of a methyl sulfonate ester that selectively generates N-3-methyladenine and poly (ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes
    • in press
    • Tentori L, Portarena I, Vernole P, Gold B, Graziani G. Apoptotic and cytotoxic effects of a methyl sulfonate ester that selectively generates N-3-methyladenine and poly (ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes. Cancer Chemother Pharmacol 2002; in press
    • (2002) Cancer Chemother Pharmacol
    • Tentori, L.1    Portarena, I.2    Vernole, P.3    Gold, B.4    Graziani, G.5
  • 159
    • 0035012606 scopus 로고    scopus 로고
    • DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression
    • Tong WM, Hande MP, Lansdorp PM, Wang ZQ. DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. Mol Cell Biol 2001; 21: 4046-54.
    • (2001) Mol Cell Biol , vol.21 , pp. 4046-4054
    • Tong, W.M.1    Hande, M.P.2    Lansdorp, P.M.3    Wang, Z.Q.4
  • 160
    • 0035796476 scopus 로고    scopus 로고
    • Loss of poly(ADP-ribose) polymerase-1 cause increased tumor latency in p53-deficient mice
    • Conde C, Mark M, Oliver FJ, Huber A, de Murcia G, Menissierde Murcia J. Loss of poly(ADP-ribose) polymerase-1 cause increased tumor latency in p53-deficient mice. EMBO J 2001; 20: 3535-43.
    • (2001) EMBO J , vol.20 , pp. 3535-3543
    • Conde, C.1    Mark, M.2    Oliver, F.J.3    Huber, A.4    De Murcia, G.5    Menissierde Murcia, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.