Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats

Journal of Neurotrauma

Volumn 18, Issue 4, 2001, Pages 369-376

  LaPlaca, M C ^a   Zhang, J ^b   Raghupathi, R ^a   Li, J H ^b   Smith, F ^c   Bareyre, F M ^a   Snyder, S H ^c   Graham, D I ^d   McIntosh, T K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Guilford Pharmaceuticals   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SOUTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; DNA damage; DNA repair; Experimental brain injury; NAD; PARP

Indexed keywords

1,11B DIHYDROBENZOPYRANO[4,3,2 DE]ISOQUINOLIN 3 ONE; DNA FRAGMENT; ENZYME INHIBITOR; GPI 6150; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CELL DAMAGE; CONTROLLED STUDY; DISEASE SEVERITY; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME INHIBITION; HISTOPATHOLOGY; MALE; MORPHOLOGY; NEUROPROTECTION; NICK END LABELING; NISSL STAINING; NONHUMAN; RAT;

EID: 0035063766     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771501750170912     Document Type: Article

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