Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase

Journal of Medicinal Chemistry

Volumn 43, Issue 22, 2000, Pages 4084-4097

  White, A W ^a   Almassy, R ^a   Calvert, A H ^b   Curtin, N J ^b   Griffin, R J ^a   Hostomsky, Z ^c   Maegley, K ^c   Newell, D R ^b   Srinivasan, S ^a   Golding, B T ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 METHOXYPHENYL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE; 2 (4 HYDROXYMETHYLPHENYL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE; 2 (4 HYDROXYPHENYL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE; 2 PHENYL 1H BENZIMIDAZOLE 4 CARBOXAMIDE; BENZIMIDAZOLE DERIVATIVE; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TEMOZOLOMIDE; TOPOTECAN; UNCLASSIFIED DRUG;

ARTICLE; DNA REPAIR; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; OVARY CARCINOMA; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CRYSTALLOGRAPHY, X-RAY; DACARBAZINE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; POLY(ADP-RIBOSE) POLYMERASES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOTECAN; TUMOR CELLS, CULTURED;

EID: 0034597569     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000950v     Document Type: Article

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