Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment

Brain Research

Volumn 915, Issue 2, 2001, Pages 210-217

  Ding, Yuchuan ^a   Zhou, Yandong ^a   Lai, Qin ^b   Li, Jie ^a   Gordon, Vickie ^a   Diaz, Fernando G ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

3 Aminobenzamide; Infarct; Ischemic stroke; Motor behavior; Neurological deficit; PARP

Indexed keywords

3 AMINOBENZAMIDE; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEAR PROTEIN;

ACCURACY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN SURGERY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; FUNCTIONAL DISEASE; HISTOPATHOLOGY; MEASUREMENT; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; REPERFUSION INJURY; REPRODUCIBILITY; STROKE; TASK PERFORMANCE; TREATMENT OUTCOME;

ANIMALS; BENZAMIDES; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; ENZYME INHIBITORS; FEMALE; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MOTOR ACTIVITY; NEUROLOGIC EXAMINATION; NEUROPROTECTIVE AGENTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035850884     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02852-9     Document Type: Article

References (45)

1. Inflammatory mediators and stroke: New opportunities for novel therapeutics
2. Functional subdivisions of the rat somatic sensorimotor cortex
3. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats
4. Correlation between behavioral status and cerebral glucose utilization in rats following freezing lesion
5. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
6. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
7. The role of inflammation after acute stroke: Utility of pursuing anti-adhesion molecule therapy
8. Impaired motor learning and deffuse axonal damage in motor and visual systems of the rat following traumatic brain injury
9. Pathobiology of ischaemic stroke: An integrated view
10. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase
11. Cellular inflammation in experimental ischemic stroke
12. Free radicals in stroke
13. Reperfusion injury after focal cerebral ischemia: The role of inflammation and the therapeutic horizon
14. Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats
15. Synaptogenesis and Fos expression in the motor cortex of the adult rat after motor skill learning
16. Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats. I. Behavioral results
17. Reperfusable brain infarction model in rat
18. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
19. Inhibition of poly(ADP-ribose) polymerase: Reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation
20. Reversible middle cerebral artery occlusion without craniectomy in rats
21. Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats
22. Alterations in gait following ethanol exposure during the brain growth spurt in rats
23. Free radical scavengers and spin traps
24. Poly (ADP-ribose) polymerase, nitric oxide and cell death
25. Novel inhibitors of poly(ADP-ribose) synthetase
26. Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat
27. Nitric oxide synthase in models of focal ischemia
28. Free radicals in central nervous system ischemia
29. Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: Influence on genomic stability, chromatin organization, DNA repair, and DNA replication
30. Inflammation and glial responses in ischemic brain lesions
31. Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats
32. Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with D-amphetamine therapy after neocortical infarction in rats
33. A semiautomated method for measuring brain infarct volume
34. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
35. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects
36. The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase
37. Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats
38. Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia
39. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle
40. Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain
41. Usual and unusual methods for detection of lipid peroxides as indicators of tissue injury in cerebral ischemia: What is appropriate and useful?
42. Brain ischemia and reperfusion: Molecular mechanisms of neuronal injury
43. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity
44. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat
45. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase