Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents

Clinical Cancer Research

Volumn 5, Issue 10, 1999, Pages 2908-2917

  Liu, Lili ^a   Taverna, Pietro ^a   Whitacre, Cecilia M ^a   Chatterjee, Satadal ^a   Gerson, Stanton L ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BASE MISPAIRING; COLON CARCINOGENESIS; COLON CARCINOMA; DNA REPLICATION; DNA STRAND BREAKAGE; DOSE RESPONSE; EXCISION REPAIR; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, ALKYLATING; CARMUSTINE; CELL CYCLE; COLONIC NEOPLASMS; DACARBAZINE; DNA REPAIR; DRUG SYNERGISM; HUMANS; HYDROXYLAMINES; ISOQUINOLINES; POLY(ADP-RIBOSE) POLYMERASES;

EID: 0032694518     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. 6-alkylguanine-DNA AGT. Prog. Nucleic Acid Res. Mol. Biol., 51: 167-233, 1995.
2. Fink, D., Aebi, S., and Howell, S. B. The role of DNA mismatch repair in drug resistance. Clin. Cancer Res., 4: 1-6, 1998.
3. Branch, P., Aquilina, G., Bignami, M., and Karran, P. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature (Lond.), 362: 652-654, 1993.
4. Kat, A., Thilly, W. C., Fang, W-H., Longley, M. J., Li, G-M., and Modrich, P. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl. Acad. Sci. USA, 90: 6424-6428, 1993.
5. Karran, P., and Bignami, M. DNA damage tolerance, mismatch repair and genome instability. BioEssays, 16: 833-839, 1994.
6. Griffin, S., Branch, P., Xu, Y-Z., and Karran, P. DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage. Biochemistry, 33: 4787-4793, 1994.
7. Liu, L., Markowitz, S., and Gerson, S. L. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide by not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Res., 56: 5375-5379, 1996.
8. O'Connor, T. R., and Laval, F. Isolation and structure of a cDNA expressing a mammalian 3-methyladenine-DNA glycosylase. EMBO J., 9: 3337-3342, 1990.
9. Samson, L., Derfkerm B., Boosalis, M., and Call, K. Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16. Proc. Natl. Acad. Sci. USA. 88: 9127-9131, 1991.
10. Neddermann, P., Gallinari, P., Lettieri, T., Schmid, D., Truong, O., Hsuan, J. J., Wiebauer, K., and Jiricny, J. Functional expression of soluble human interleukin-11 (IL-11) receptor α and stoichiometry of in vitro IL-11 receptor complexes with gp130. J. Biol. Chem., 271: 12767-12774, 1996.
11. Vollberg, T. M., Siegler, K. M., Cool, B. L., and Sirover, M. A. Isolation and characterization of the human uracil DNA glycosylase gene. Proc. Natl. Acad. Sci. USA, 86: 8693-8697, 1989.
12. Olsen, L. C., Aasland, R., Wittwer, C. U., Krokan, H. E., and Helland, D. E. Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme. EMBO J., 8: 3121-3125, 1989.
13. Radicella, J. P., Dherin, C., Desmaze, C., Fox, M. S., and Boiteux, S. Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA, 94: 8010-8015, 1997.
14. Rosenquist, T. A., Zharkov, D. O., and Grollman, A. P. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc. Natl. Acad. Sci. USA, 94: 7429-7434, 1997.
15. Willson, S. H. Mammalian base excision repair and DNA polymerase β. Mutation Res., 407: 203-215, 1998.
16. Molinete, M., Vermeulen, W., Burkle, A., Menissier-de Murcia, J., Kupper, J. H., Hoeijmakers, J. H. J., and de Murcia, G. Overproduction of the poly (ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells. EMBO J., 12: 2109-2117, 1993.
17. Caldecott, K. W., Aoufouchi, S., Johnson, P., and Shall, S. XRCC1 polypeptide interacts with DNA polymerase β and possibly poly(ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. Nucleic Acids Res., 24: 4387-4394, 1996.
18. Sobol, R. W., Horton, J. K., Kuhn, R., Gu, H. Singhal, R. K., Prasad, R., Rajewsky, K., and Wilson, S. H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature (Lond.), 379: 183-186, 1996.
19. Walker, L. J., Craig, R. B., Harris, A. L., and Hickson, I. D. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res., 22: 4884-4889, 1994.
20. Engelward, B. P., Dreslin, A., Christensen, J., Huszar, D., Kurahara, C., and Samson, L. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing. EMBO J., 15: 945-952, 1996.
21. Coquerelle, T., Dosch, J., and Kaina, B. Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents - a case of unbalanced DNA repair. Mutat. Res., 336: 9-17, 1995.
22. Menissier-de Murcia, J., Niedergang, C., Trucco, C., Ricoul, M., Dutrillaux, B., Mark, M., Oliver, F. J., Masson, M., Dierich, A., Le-Meur, M., Walztinger, C., Chambon, P., and de Murcia, G. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. USA, 94: 7303-7304, 1997.
23. Boulton, S., Pemberton, L. C., Porteous, J. K., Curtin, N. J., Griffin, R. J., Golding, B. T., and Durkacz, B. W. Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors. Br. J. Cancer, 72: 849-856, 1995.
24. Fortini, P., Calcagnile, A., Vrieling, H., van Zeeland, A. A., Bignami, M., and Dogliotti, E. Mutagenic processing of ethylation damage in mammalian cells: the use of methoxyamine to study apurinic/apyrimidinic site-induced mutagenesis. Cancer Res., 53: 1149-1155, 1993.
25. Chou, T. C., and Talalay, P. Quantitative analysis of dose-effect relationship: the combined effects of multiple drugs on enzyme inhibitors. In: G. Weber (ed.), Advances in Enzyme Regulation, pp. 27-55. New York: Pergamon Press, 1983.
26. Liuzzi, M., and Talpeart-Borle, M. A new approach to the study of the base-excision repair pathway using methoxyamine. J. Biol. Chem., 260: 5252-5258, 1985.
27. Rosa, S., Fortini, P., Bignami, M., and Dogliotti, E. Processing in vitro of an abasic site reacted with methoxyamine: a new assay for the detection of abasic sites formed in vivo. Nucleic Acids Res., 19: 5569-5574, 1991.
28. Fortini, P., Rosa, S., Zijno, A., Calcagnile, A., Bignami, M., and Dogliotti, E. Methoxyamine modification of abasic sites protects CHO cells from the cytotoxic and mutagenic effects of oxygen alkylation. Carcinogenesis (Lond.), 13: 87-93, 1992.
29. Kingma, P. S., and Osheroff, N. Apurinic sites are position-specific topoisomerase II poisons. J. Biol. Chem., 272: 1148-1155, 1997.
30. Robertson, K. A., Hill, D. P., Xu, Y., Liu, L., Epps, S. V., Hockenbery, D. M., Park, J. R., Wilson, T. M., and Kalley, M. R. Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells. Cell Growth & Differ., 8: 443-449, 1997.
31. Buschfort, C., Muller, M. R., Seeber, S., Rajewsky, M. F., and Thomale, J. DNA excision repair profiles of normal and leukemic human lymphocytes: functional analysis at the single-cell level. Cancer Res., 57: 651-658, 1997.
32. Althaus, F. R., Hofferer, L., Kleczkowska, H. E., Malanga, M., Naegeli, H., Panzeter, P., and Realini, C. Histone shuttle driven by the automodification cycle of poly(ADP-ribose) polymerase. Environ. Mol. Mutagen., 22: 278-282, 1993.
33. 6-alkylguanine-DNA alkyltransferase activity. Br. J. Cancer, 74: 1030-1036, 1996.
34. Wilson, D. M., III, and Thompson, L. H. Life without DNA repair. Proc. Natl. Acad. Sci. USA, 94: 7303-7304, 1997.
35. 6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA. Cancer Res., 52: 6052-6058, 1992.
36. Prakash, A. S., and Gibson, N. W. Sequence-selective depurination, DNA interstrand cross-linking and DNA strand break formation associated with alkylated DNA. Carcinogenesis (Lond.)., 13: 425-431, 1992.
37. Malapetsa, A., Noe, A. J., Poirier, G. G., Desnoyers, S., Berger, N. A., and Panasci, L. C. Identification of a 116 kDa protein able to bind 1,3-bis (2-chloroethyl)-1-nitrosourea-damaged DNA as poly(ADP-ribose) polymerase. Mutat. Res., 362: 41-50, 1996.
38. Matijasevic, Z., Boosalis, M., Mackay, W., Samson, L., and Ludlum, D. B. Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase. Proc. Natl. Acad. Sci. USA, 90: 11855-11859, 1993.
39. 6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models. Mutat. Res., 381: 227-241, 1997.
40. Lindahl, T., Satoh M. S., Poirier, G. G., and Klungland A. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci., 20: 405-411, 1995.
41. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (Lond.), 371: 346-347, 1994.
42. Moms, S. M., Domon, O. E., McGarrity, L. J., Kodell, R. L., and Casciano, D. A. Flow cytometric evaluation of cell-cycle progression in ethylmethanesulfonate and methylmethonesulfonate exposed P3 cells: relationship to the induction of sister-chromatid exchanges and cellular toxicity. Environ. Mol. Mutagen., 18: 139-149, 1991.
43. Engelward, B. P., Allan, J. M., Dreslin, A. J., Kelly, J. D., Wu, M. M., Gold, B., and Samson, L. D. A chemical and genetic approach together define the biological consequences of 3-methyladenine lesion in the mammalian genome. J. Biol. Chem., 273: 5412-5418, 1998.