Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice

EMBO Journal

Volumn 20, Issue 13, 2001, Pages 3535-3543

  Conde, Carmen ^a   Mark, Manuel ^b   Oliver, F Javier ^c   Huber, Aline ^a   De Murcia, Gilbert ^a   Ménissier De Murcia, Josiane ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

irradiation; Cell cycle; iNOS expression; Knockout mice; Nude mice

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; NITRITE; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; EXCISION REPAIR; GAMMA IRRADIATION; INFLAMMATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; SURVIVAL;

ANIMALS; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CROSSES, GENETIC; DISEASE-FREE SURVIVAL; DNA REPAIR; FEMALE; FIBROBLASTS; GAMMA RAYS; GENES, P53; GENES, RAS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, NUDE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; NEOPLASMS, EXPERIMENTAL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035796476     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.13.3535     Document Type: Article

References (57)

1. p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells
2. Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice
3. 2BP)
4. DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53
5. Poly(ADP-ribose) in the cellular response to DNA damage
6. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic β-cell destruction and diabetes development induced by streptozocin
7. Nitric oxide-induced deamination of cytosine and guanine in deoxynucleosides and oligonucleotides
8. Expression of nitric oxide synthase in human central nervous system tumors
9. Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose) polymerase-1
10. Poly(ADP-ribose) polymerase: A molecular nick-sensor
11. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
12. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
13. Measurement of micronuclei in lymphocytes
14. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53
15. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
16. Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: Evidence for increased tumor cell apoptosis in vivo
17. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
18. A role of poly(ADP-ribose) polymerase in NF-κB transcriptional activation
19. Tumor spectrum analysis in p53-mutant mice
20. Roles of nitric oxide in tumor growth
21. Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis
22. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
23. Inducible nitric oxide synthase is expressed in tumor-associated vasculature: Inhibition retards tumor growth in vivo
24. Regulation of p53 in response to DNA damage
25. Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice
26. p53, the cellular gatekeeper for growth and division
27. Inducible nitric oxide synthase, nitrotyrosine and apoptosis in Helicobacter pylori gastritis: Effect of antibiotics and antioxidants
28. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
29. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
30. The response of Parp knockout mice against DNA damaging agents
31. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
32. shc adaptor protein controls oxidative stress response and life span in mammals
33. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells
34. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
35. Induction of nitric oxide synthase in human mesangial cells
36. Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly(ADP-ribose) polymerase-1 deficient mice
37. Regulation of the p53 tumor suppressor protein
38. Poly(ADP-ribose) polymerase, nitric oxide and cell death
39. Myocardial postischemic injury is reduced by polyADPribose polymerase-1 gene disruption
40. Role of the INK4a locus in tumor suppression and cell mortality
41. INK4a
42. Chromosomal aberrations in PARP(-/-) mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA
43. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
44. The cellular response to p53: The decision between life and death
45. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
46. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
47. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase
48. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase
49. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
50. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle
51. Nitric oxide synthase activity in human gynecological cancer
52. Nitric oxide synthase activity in human breast cancer
53. DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines
54. Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase
55. Rapid up-regulation of IκBβ and abrogation of NF-κB activity in peritoneal macrophages stimulated with lipopolysaccharide
56. PARP is important for genomic stability but dispensable in apoptosis
57. Genetic disruption of poly(ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury