Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: Long-term morphological and functional consequences

British Journal of Pharmacology

Volumn 133, Issue 8, 2001, Pages 1424-1430

  Liaudet, Lucas ^a,b   Szabó, Éva ^a   Timashpolsky, Leonid ^a   Virág, László ^a   Cziráki, Attila ^c   Szabó, Csaba ^a,b  

^a INOTEK CORPORATION   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PÉCS   (Hungary)

Author keywords

3 aminobenzamide; Heart; Ischaemia; Poly(ADP ribose) polymerase (PARP); Reperfusion

Indexed keywords

3 AMINOBENZAMIDE; CREATINE KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME LOCALIZATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE REPERFUSION; IMMUNOHISTOCHEMISTRY; MALE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 0034870585     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704185     Document Type: Article

References (20)

1. Inhibitors of the activity of poly (ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts
2. Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig
3. An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart
4. Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts in vitro
5. Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts
6. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
7. Surgical procedure affects physiological parameters in rat myocardial ischemia: Need for mechanical ventilation
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9. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase
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12. BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase
13. DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite
14. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-ribose) synthetase
15. Inhibition of the activity of poly(ADP ribose) synthase reduces ischemia-reperfusion injury in the heart and skeletal muscle
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18. Inhibition of poly (ADP ribose) synthetase protects against myocardial ischemia and reperfusion injury
19. Genetic disruption of poly (ADP ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia-reperfusion injury