Inhibition of O6-Alkylguanine DNA-Alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide

Molecular Pharmacology

Volumn 52, Issue 2, 1997, Pages 249-258

  Tentori, Lucio ^a   Orlando, Laura ^a   Lacal, Pedro Miguel ^b   Benincasa, Elena ^a,b   Faraoni, Isabella ^a   Bonmassar, Enzo ^a,c   D'Atri, Stefania ^b   Graziani, Grazia ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; BENZAMIDE DERIVATIVE; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; ETOPOSIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TEMOZOLOMIDE; TRIAZENE DERIVATIVE; ALKYLATING AGENT; DACARBAZINE; DNA; DRUG DERIVATIVE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE;

ACUTE LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN 3T3; CONTROLLED STUDY; DNA METHYLATION; DNA REPAIR; DRUG CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ETIOLOGY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; LEUKEMIA; METABOLISM; PATHOLOGY;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; DACARBAZINE; DNA FRAGMENTATION; DNA METHYLATION; DNA REPAIR; DNA, NEOPLASM; HUMANS; LEUKEMIA; METHYLTRANSFERASES; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POLY(ADP-RIBOSE) POLYMERASES; TUMOR CELLS, CULTURED;

EID: 0030611436     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.2.249     Document Type: Article

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