Regulation of nuclear import and export by the GTPase ran

International Review of Cytology

Volumn 217, Issue , 2002, Pages 41-91

  Steggerda, Susanne M ^a,b   Paschal, Bryce M ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Exportin; Importin; Karyopherin; Nuclear export signal; Nuclear localization signal; Nuclear pore complex; Nuclear transport

Indexed keywords

GUANOSINE TRIPHOSPHATASE;

CELL COMPARTMENTALIZATION; DNA REPLICATION; ENDOPLASMIC RETICULUM; ENZYME REGULATION; MACROMOLECULE; NONHUMAN; NUCLEAR IMPORT; NUCLEAR PORE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN RNA BINDING; RECEPTOR BINDING; REVIEW; RNA SYNTHESIS;

EID: 0036264236     PISSN: 00747696     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0074-7696(02)17012-4     Document Type: Review

References (269)

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189. Molecular dissection of the nuclear pore complex
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191. CRM1-mediated recycling of snurportin 1 to the cytoplasm
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194. High levels of the GTPase Ran/TC4 relieve the requirement for nuclear protein transport factor 2
195. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62
196. Transport routes through the nuclear pore complex
197. A distinct and parallel pathway for the nuclear import of an mRNA-binding protein
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199. The HIV-1 Rev protein
200. A novel receptor-mediated nuclear protein import pathway
201. The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport
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209. The 1.7 A crystal structure of the regulator of chromosome condensation (RCC 1) reveals a seven-bladed propeller
210. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport, factors, and nucleoporins
211. The translocation of transportincargo complexes through nuclear pores is independent of both Ran and energy
212. NTF2 mediates nuclear import of Ran
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214. A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1
215. The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1
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219. The nuclear pore complex: A protein machine bridging the nucleus and cytoplasm
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221. The RCC1 protein interacts with Ran, RanBP1, hsc70, and a 340-kDa protein in Xenopus extracts
222. Ubc9p and the Conjugation of Sumo-1 to Rangap1 and Ranbp2
223. Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2
224. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
225. A fission yeast RCC1-related protein is required for the mitosis to interphase transition
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227. Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form
228. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Np13p
229. The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases
230. A nuclear localization domain in the hnRNP A1 protein
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233. Monoclonal antibodies identify a group of nuclear pore complex glycoproteins
234. Cse1p is involved in export of yeast importin alpha from the nucleus
235. Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha
236. Invasion of the nucleotide snatchers: Structural insights into the mechanism of G protein GEFs
237. Exportin 1 (Crm1p) is an essential nuclear export factor
238. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase ran
239. The mammalian Mog1 protein is a guanine nucleotide release factor for Ran
240. Identification of a conserved loop in Mog1 that releases GTP from Ran
241. O-linked glycoproteins of the nuclear pore complex interact with a cytosolic factor required for nuclear protein import
242. 1.9 A resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p
243. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran
244. The nuclear pore complex: From molecular architecture to functional dynamics
245. Loss of RCC1 leads to suppression of nuclear protein import in living cells
246. RAS2 of Saccharomyces cerevisiae is required for gluconeogenic growth and proper response to nutrient limitation
247. Fission yeast Moglp homologue, which interacts with the small GTPase Ran, is required for mitosis-to-interphase transition and poly(A)(+) RNA metabolism
248. A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export
249. Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue
250. Nucleus-associated pools of Rna1p, the Saccharomyces cerevisiae Ran/TC4 GTPse activating protein involved in nucleus/cytosol transit
251. Structural view of the Ran-Importin beta interaction at 2.3 A resolution
252. Structure of a Ranbinding domain complexed with Ran bound to a GTP analogue: Implications for nuclear transport
253. Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta
254. The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+RNA export
255. Nucleo-cytoplasmic distribution of human hnRNP proteins: A search for the targeting domains in hnRNP A1
256. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences
257. RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3
258. Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal
259. Identification of a signal for rapid export of proteins from the nucleus
260. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
261. Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport
262. Nup358, a cytoplasmically exposed nucleoporin with peptide repeats Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region
263. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae
264. Cloning and characterization of SRP1, a suppressor of temperature-sensitive RNA polymerase I mutations, in Saccharomyces cerevisiae
265. GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin Nup358
266. Two distinct classes of Ran-binding sites on the nucleoporin Nup-358
267. A giant nucleopore protein that binds Ran/TC4
268. tRNA transport from the nucleus in a eukaryotic cell: Carrier-mediated translocation process
269. Nuclear export of mRNA