RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro

Molecular and Cellular Biology

Volumn 20, Issue 13, 2000, Pages 4562-4571

  Ossareh Nazari, Batool ^a   Maison, Christèle ^a   Black, Ben E ^b   Lévesque, Lyne ^b   Paschal, Bryce M ^b   Dargemont, Catherine ^a,c  

^a INSTITUT CURIE   (France)

^b UNIVERSITY OF VIRGINIA   (United States)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; RNA; SMALL NUCLEAR RNA; TRANSFER RNA;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; XENOPUS;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; FEMALE; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; KARYOPHERINS; METHYLATION; MOLECULAR BIOLOGY; MUTATION; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; RAN GTP-BINDING PROTEIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA; RNA CAPS; RNA, MESSENGER; RNA, SMALL NUCLEAR; RNA, TRANSFER, MET;

EID: 0034121073     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.13.4562-4571.2000     Document Type: Article

References (53)

1. Adam, S. A., R. S. Marr, and L. Gerace. 1990. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111:807-816.
2. Agutter, P. S., H. J. McArdle, and B. McCaldin. 1976. Evidence for involvement of nuclear envelope nucleoside triphosphatase in nucleocytoplasmic translocation of ribonucleoprotein. Nature 263:165-167.
3. Arts, G. J., L. Englmeier, and I. W. Mattaj. 1997. Energy- and temperature-dependent in vitro export of RNA from synthetic nuclei. Biol. Chem. 378: 641-649.
4. Arts, G. J., M. Fornerod, and I. W. Mattaj. 1998. Identification of a nuclear export receptor for tRNA. Curr. Biol. 8:305-314.
5. Black, B. E., L. Lévesque, J. M. Holaska, T. C. Wood, and B. M. Paschal. 1999. Identification of an NTF2-related factor that binds Ran-GTP and regulated nuclear protein export. Mol. Cell. Biol. 19:8616-8624.
6. Coverley, D., C. S. Downes, P. Romanowski, and R. A. Laskey. 1993. Reversible effects of nuclear membrane permeabilization on DNA replication: evidence for a positive licensing factor. J. Cell Biol. 122:985-992.
7. Dargemont, C., and L. C. Kuhn. 1992. Export of mRNA from microinjected nuclei of Xenopus laevis oocytes. J. Cell Biol. 118:1-9.
8. Dasso, M., T. Seki, Y. Azuma, T. Ohba, and T. Nishimoto. 1994. A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation. EMBO J. 13:5732-5744.
9. Fischer, U., J. Huber, W. C. Boelens, I. W. Mattaj, and R. Luhrmann. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82:475-483.
10. Fischer, U., S. Meyer, M. Teufel, C. Heckel, R. Luhrmann, and G. Rautmann. 1994. Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA. EMBO J. 13:4105-4112.
11. Fornerod, M., M. Ohno, M. Yoshida, and I. W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90:1051-1060.
12. Fukuda, M., S. Asano, T. Nakamura, M. Adachi, M. Yoshida, M. Yanagida, and E. Nishida. 1997. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390:308-311.
13. Gorlich, D., S. Prehn, R. A. Laskey, and E. Hartmann. 1994. Isolation of a protein that is essential for the first step of nuclear protein import. Cell 79: 767-778.
14. Gruter, P., C. Tabernero, C. von Kobbe, C. Schmitt, C. Saavedra, A. Bachi, M. Wilm, B. K. Felber, and E. Izaurralde. 1998. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell 1:649-659.
15. Hamm, J., and I. W. Mattaj. 1990. Monomethylated cap structures facilitate RNA export from the nucleus. Cell 63:109-118.
16. Hellmuth, K., D. M. Lau, F. R. Bischoff, M. Kunzler, E. Hurt, and G. Simos. 1998. Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA. Mol. Cell. Biol. 18:6374-6386.
17. Hopper, A. K., H. M. Traglia, and R. W. Dunst. 1990. The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus. J. Cell Biol. 111:309-321.
18. Izaurralde, E., A. Jarmolowski, C. Beisel, I. W. Mattaj, G. Dreyfuss, and U. Fischer. 1997. A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J. Cell Biol. 137:27-35.
19. Izaurralde, E., U. Kutay, C. von Kobbe, I. W. Mattaj, and D. Gorlich. 1997. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J. 16:6535-6547.
20. Izaurralde, E., J. Lewis, C. Gamberi, A. Jarmolowski, C. McGuigan, and I. W. Mattaj. 1995. A cap-binding protein complex mediating U snRNA export. Nature 376:709-712.
21. Izaurralde, E., J. Stepinski, E. Darzynkiewicz, and I. W. Mattaj. 1992. A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs. J. Cell Biol. 118:1287-1295.
22. Jarmolowski, A., W. C. Boelens, E. Izaurralde, and I. W. Mattaj. 1994. Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol. 124:627-635.
23. Jenkins, Y., M. McEntee, K. Weis, and W. C. Greene. 1998. Characterization of HIV-1 vpr nuclear import: analysis of signals and pathways. J. Cell Biol. 143:875-885.
24. Kadowaki, T., M. Hitomi, S. Chen, and A. M. Tartakoff. 1994. Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant. Mol. Biol. Cell 5:1253-1263.
25. Katahira, J., K. Strasser, A. Podtelejnikov, M. Mann, J. U. Jung, and E. Hurt. 1999. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J. 18:2593-2609.
26. Kehlenbach, R. H., A. Dickmanns, A. Kehlenbach, T. Guan, and L. Gerace. 1999. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. J. Cell Biol. 145:645-657.
27. Klebe, C., F. R. Bischoff, H. Ponstingl, and A. Wittinghofer. 1995. Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1. Biochemistry 34:639-647.
28. Kutay, U., G. Lipowsky, E. Izaurralde, F. K. Bischoff, P. Schwarzmaier, E. Hartmann, and D. Gorlich. 1998. Identification of a tRNA-specific nuclear export receptor. Mol. Cell 1:359-369.
29. Lee, M. S., M. Henry, and P. A. Silver. 1996. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export. Genes Dev. 10:1233-1246.
30. Leno, G. H., C. S. Downes, and R. A. Laskey. 1992. The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract. Cell 69:151-158.
31. Lund, E., and J. E. Dahlberg. 1998. Proofreading and aminoacylation of tRNAs before export from the nucleus. Science 282:2082-2085.
32. Malim, M. H., J. Hauber, S. Y. Le, J. V. Maizel, and B. R. Cullen. 1989. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature 338:254-257.
33. Mattaj, I. W., and L. Englmeier. 1998. Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem. 67:265-306.
34. Melchior, F., and L. Gerace. 1998. Two-way trafficking with Ran. Trends Cell Biol. 8:175-179.
35. Melchior, F., B. Paschal, J. Evans, and L. Gerace. 1993. Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol. 123: 1649-1659. (Erratum, 124:217, 1994.)
36. Michael, W. M., M. Choi, and G. Dreyfuss. 1995. A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83:415-422.
37. Moore, M. S., and G. Blobel. 1993. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365:661-663.
38. Moroianu, J., M. Hijikata, G. Blobel, and A. Radu. 1995. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc. Natl. Acad. Sci. USA 92: 6532-6536.
39. Ohtsubo, M., H. Okazaki, and T. Nishimoto. 1989. The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA. J. Cell Biol. 109:1389-1397.
40. Ossareh-Nazari, B., F. Bachelerie, and C. Dargemont. 1997. Evidence for a srole of CRM1 in signal-mediated nuclear protein export. Science 278:141-144.
41. Pasquinelli, A. E., R. K. Ernst, E. Lund, C. Grimm, M. L. Zapp, D. Rekosh, M. L. Hammarskjold, and J. E. Dahlberg. 1997. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. EMBO J. 16:7500-7510.
42. Pollard, V. W., W. M. Michael, S. Nakielny, M. C. Siomi, F. Wang, and G. Dreyfuss. 1996. A novel receptor-mediated nuclear protein import pathway. Cell 86:985-994.
43. Ribbeck, K., G. Lipowsky, H. M. Kent, M. Stewart, and D. Gorlich. 1998. NTF2 mediates nuclear import of Ran. EMBO J. 17:6587-6598.
44. Richards, S. A., K. L. Carey, and I. G. Macara. 1997. Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export. Science 276:1842-1844.
45. Santos-Rosa, H., H. Moreno, G. Simos, A. Segref, B. Fahrenkrog, N. Pante, and E. Hurt. 1998. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores. Mol. Cell. Biol. 18:6826-6838.
46. Schroder, H. C., U. Friese, M. Bachmann, T. Zaubitzer, and W. E. Muller. 1989. Energy requirement and kinetics of transport of poly(A)-free histone mRNA compared to poly(A)-rich mRNA from isolated L-cell nuclei. Eur. J. Biochem. 181:149-158.
47. Segref, A., K. Sharma, V. Doye, A. Hellwig, J. Huber, R. Luhrmann, and E. Hurt. 1997. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J. 16:3256-3271.
48. Smith, A., A. Brownawell, and I. G. Macara. 1998. Nuclear import of Ran is mediated by the transport factor NTF2. Curr. Biol. 8:1403-1406.
49. Stade, K., C. S. Ford, C. Guthrie, and K. Weis. 1997. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90:1041-1050.
50. Steggerda, S. M. S., B. E. Black, and B. M. Paschal. 2000. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. Mol. Biol. Cell 11:703-719.
51. Terns, M. P., and J. E. Dahlberg. 1994. Retention and 5́ cap trimethylation of U3 snRNA in the nucleus. Science 264:959-961.
52. Terns, M. P., J. E. Dahlberg, and E. Lund. 1993. Multiple cis-acting signals for export of pre-U1 snRNA from the nucleus. Genes Dev. 7:1898-1908.
53. Wozniak, R. W., M. P. Rout, and J. D. Aitchison. 1998. Karyopherins and kissing cousins. Trends Cell Biol. 8:184-188.