Nuclear protein import: Ran-GTP dissociates the karyopherin αβ heterodimer by displacing a from an overlapping binding site on β

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 14, 1996, Pages 7059-7062

  Moroianu, Junona ^a   Blobel, Günter ^a   Radu, Aurelian ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Digitonin permeabilized cells; Karyopherin mutant; Liquid phase binding assay; Synthetic peptides

Indexed keywords

RUMEX;

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MUTANT PROTEIN; NUCLEAR PROTEIN; SYNTHETIC PEPTIDE;

ALPHA CHAIN; ARTICLE; BETA CHAIN; BINDING COMPETITION; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TRANSPORT; STOICHIOMETRY;

ALPHA KARYOPHERINS; AMINO ACID SEQUENCE; ANIMALS; BETA KARYOPHERINS; BINDING SITES; CELL NUCLEUS; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMANS; KINETICS; LIVER; MACROMOLECULAR SUBSTANCES; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PROTEIN HYBRIDIZATION; PROTEIN STRUCTURE, SECONDARY; RAN GTP-BINDING PROTEIN; RATS; RATS, INBRED BUF; RECOMBINANT PROTEINS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0029982848     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.14.7059     Document Type: Article

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