Calreticulin is a receptor for nuclear export

Journal of Cell Biology

Volumn 152, Issue 1, 2001, Pages 127-140

  Holaska, James M ^a,b   Black, Ben E ^a,b   Love, Dona C ^c   Hanover, John A ^c   Leszyk, John ^d   Paschal, Bryce M ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

GTPase; Hormone receptor; Nuclear pore complex; Nucleocytoplasmic transport; Protein export; Ran

Indexed keywords

CALRETICULIN; GLUCOCORTICOID RECEPTOR; GREEN FLUORESCENT PROTEIN; HORMONE RECEPTOR; RECEPTOR PROTEIN;

ARTICLE; CELL NUCLEUS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; CALCIUM-BINDING PROTEINS; CALRETICULIN; CARRIER PROTEINS; CELL NUCLEUS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSOL; FATTY ACIDS, UNSATURATED; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; RAN GTP-BINDING PROTEIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GLUCOCORTICOID; RIBONUCLEOPROTEINS;

NES;

EID: 0035825129     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.1.127     Document Type: Article

References (59)

1. Identification of a nuclear export receptor for tRNA
2. The role of exportin-t in selective nuclear export of mature tRNAs
3. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP
4. RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase
5. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export
6. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus
7. Modulation of gene expression by calreticulin binding to the glucocorticoid receptor
8. 2+ waves
9. Evidence using a green fluorescent protein - Glucocorticoid receptor chimera that the Ran/TC4 GTPase mediates an essential function independent of nuclear protein import
10. Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen
11. Heat shock-sensitive expression of calreticulin. In vitro and in vivo up-regulation
12. Connections between the processing and nuclear export of mRNA: Evidence for an export license?
13. Inhibition of nuclear hormone receptor activity by calreticulin
14. From nucleoporins to nuclear pore complexes
15. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
16. CRM1 is an export receptor for leucine-rich nuclear export signals
17. Transport between the cell nucleus and the cytoplasm
18. A novel class of RanGTP binding proteins
19. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
20. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Glelp and suppresses the mRNA export defect of xpo1-1 cells
21. A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells
22. Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae
23. A cap-binding protein complex mediating U snRNA export
24. Intracellular distribution of heat-induced stress glycoproteins
25. The translocon: A dynamic gateway at the ER membrane
26. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
27. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export
28. Evidence for distinct substrate specificities of importin β family members in nuclear protein import
29. Calreticulin
30. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
31. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
32. Identification of a tRNA-specific nuclear export receptor
33. Protracted nuclear export of the glucocorticoid receptor limits its turnover and does not require the exportin1/CRM1-directed nuclear export pathway
34. Reconstitution of HIV-1 rev nuclear export: Independent requirements for nuclear import and export
35. Protein translocation: Tunnel vision
36. Calreticulin is essential for cardiac development
37. An RNA-export mediator with an essential nuclear export signal
38. GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function
39. Identification and characterization of host factor interactions with cis-acting elements of rubella virus RNA
40. Transport of proteins and RNAs in and out of the nucleus
41. The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae
42. Nucleocytoplasmic transport: The last 200 nanometers
43. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
44. The RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro
45. Isolation of a high affinity calcium-binding protein from sarcoplasmic reticulum
46. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62
47. In vitro reconstitution of calreticulin-substrate interactions
48. RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains
49. Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export
50. Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors
51. Real-time assay of the interaction of a GST fusion protein with a protein ligate using resonant mirror technique
52. Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins
53. Exportin 1 (Crm1p) is an essential nuclear export factor
54. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran
55. Lectins as chaperones in glycoprotein folding
56. Mechanisms of progesterone receptor export from nuclei: Role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate
57. Oligosaccharide binding characteristics of the molecular chaperones calnexin and calreticulin
58. Identification of a signal for rapid export of proteins from the nucleus
59. Calreticulin inhibits vitamin D3 signal transduction