NXT1 is necessary for the terminal step of Crm1-mediated nuclear export

Journal of Cell Biology

Volumn 152, Issue 1, 2001, Pages 141-155

  Black, Ben E ^a   Holaska, James M ^a   Lévesque, Lyne ^a   Ossareh Nazari, Batool ^b   Gwizdek, Carol ^b   Dargemont, Catherine ^b   Paschal, Bryce M ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b INSTITUT JACQUES MONOD   (France)

Author keywords

Crm1; NES; Nuclear transport; NXT1; Ran

Indexed keywords

CARRIER PROTEIN; EXPORTIN 1; NUCLEAR PROTEIN; PROTEIN NXT1; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS MEMBRANE; CYTOPLASM; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CARRIER PROTEINS; CELL LINE; CELL NUCLEUS; GENE PRODUCTS, REV; GENES, REPORTER; KARYOPHERINS; MUTAGENESIS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; RNA, SMALL NUCLEAR; RNA, TRANSFER; TIME FACTORS;

EID: 0035825187     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.1.141     Document Type: Article

References (43)

1. RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase
2. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
3. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1
4. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export
5. 1.6 Å structure of nuclear transport factor 2 (NTF2)
6. Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran
7. Nuclear RNA export pathways
8. RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex
9. Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis
10. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
11. CRM1 is an export receptor for leucine-rich nuclear export signals
12. Transport between the cell nucleus and the cytoplasm
13. Isolation of a protein that is essential for the first step of nuclear protein import
14. Tap, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
15. Regulation of retroviral RNA export
16. A cytosolic activity distinct from Crml mediates nuclear export of protein kinase inhibitor in permeabilized cells
17. Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element
18. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
19. Nucleocytoplasmic shuttling factors including Ran and Crml mediate nuclear export of NFAT in vitro
20. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export
21. Reconstitution of HIV-1 Rev nuclear export -independent requirements for nuclear import and export
22. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
23. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
24. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
25. Purification of a Ran-interacting protein that is required for protein import into the nucleus
26. Transport of proteins and RNAs in and out of the nucleus
27. Domains of Crm1 involved in the formation of the Crm1, RanGTP, and leucine-rich nuclear export sequences trimeric complex
28. RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro
29. CRM1-mediated recycling of snurportin 1 to the cytoplasm
30. Identifcation of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62
31. Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97
32. The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1
33. A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1
34. Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase
35. Monoclonal antibodies identify a group of nuclear pore complex glycoproteins
36. A second post-transcriptional transactivator gene required for HTLV-III replication
37. Exportin 1 (Crm1p) is an essential nuclear export factor
38. The mammalian Mog1 protein is a guanine nucleotide release factor for Ran
39. HIV nuclear import: What's the flap?
40. The nuclear pore complex: From molecular architecture to functional dynamics
41. Identification of a signal for rapid export of proteins from the nucleus
42. Gatekeepers of the nucleus
43. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA