Pseudosubstrate regulation of the SCFβ-TrCP ubiquitin ligase by hnRNP-U

Genes and Development

Volumn 16, Issue 4, 2002, Pages 439-451

  Davis, Matti ^a   Hatzubai, Ada ^a   Andersen, Jens S ^b   Ben Shushan, Etti ^a   Fisher, Gregory Zvi ^a   Yaron, Avraham ^a   Bauskin, Asne ^c   Mercurio, Frank ^d   Mann, Matthias ^b   Ben Neriah, Yinon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d CELGENE CORPORATION   (United States)

Author keywords

TrCP E3RS; HnRNP U; I B ; Nuclear transport; Ubiquitin ligase

Indexed keywords

LIGASE; RECEPTOR SUBUNIT; UBIQUITIN;

ARTICLE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ISOLATION; PROTEIN STABILITY;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CHO CELLS; CRICETINAE; CRICETULUS; DNA-BINDING PROTEINS; GTP-BINDING PROTEINS; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN U; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; I-KAPPA B PROTEINS; MACROMOLECULAR SUBSTANCES; MICE; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PEPTIDE SYNTHASES; POINT MUTATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBONUCLEOPROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; SUBCELLULAR FRACTIONS; SUBSTRATE SPECIFICITY; UBIQUITIN;

EID: 18244371973     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.218702     Document Type: Article

References (56)

1. Stimulation-dependent IκBα phosphorylation marks the NF-κB inhibitor for degradation via the ubiquitin-proteasome pathway
2. Nuclear localization of pIκBα promotes active transport of NF-κB from the nucleus to the cytoplasm
3. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
4. Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4
5. SCF and cullin/ring H2-based ubiquitin ligases
6. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
7. HOS, a human homolog of Slimb, forms in SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and β-catenin
8. The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1
9. Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism
10. The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown
11. A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals
12. The ubiquitin system
13. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation
14. The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
15. Structure of an IκBα/ NF-κB complex
16. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα
17. Phosphorylation meets ubiquitination: The control of NF-κB activity
18. Primary structure and binding activity of the hnRNP U protein: Binding RNA through RGG box
19. hnRNP complexes: Composition, structure, and function
20. Proteolysis and the G1-S transition: The SCF connection
21. The 2.0 Å crystal structure of a heterotrimeric G protein
22. Substrate targeting in the ubiquitin system
23. βTrCP ubiquitin ligase
24. Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein
25. A ubiquitin ligase complex essential for the NF-κB Wnt/wingless, and hedgehog signaling pathways
26. A novel human WD protein, h-β-TrCP, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
27. IKK-1 and IKK-2: Cytokine-activated IKB kinases essential for NF-κB activation
28. Transport of proteins and RNAs in and out of the nucleus
29. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
30. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
31. Combinatorial control in ubiquitin-dependent proteolysis: Don't Skp the F-box hypothesis
32. Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins
33. The oncogenic activation of β-catenin
34. β-TrCP-dependent ubiquitination of IκBα
35. Inducible NF-κB activation is permitted by simultaneous degradation of nuclear IκBα
36. Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements
37. Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system
38. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex
39. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
40. A strategy for identifying gel-separated proteins in sequence databases by MS alone
41. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
42. Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1
43. Crystal structure of a G-protein β γ dimer at 2.1Å resolution
44. Homodimer of two F-box proteins β-TrCP1 or β-TrCP2 binds to IκBα for signal-dependent ubiquitination
45. IκB family members function by different mechanisms
46. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I κ B α
47. Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia
48. Characterization of IκBα nuclear import pathway
49. The ubiquitin system
50. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry
51. Structural basis of Smad2 recognition by the Smad anchor for receptor activation
52. Inhibition of NF-κB cellular function via specific targeting of the IκB-ubiquitin ligase
53. Identification of the receptor component of the IκBα-ubiquitin ligase
54. HTLV-1 Tax protein binds to MEKK1 to stimulate IKB kinase activity and NF-κB activation
55. MDM2-dependent ubiquitination of nuclear and cytoplasmic P53
56. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases