Functional consequences of a polymorphism affecting NF-κB p50-p50 binding to the TNF promoter region

Molecular and Cellular Biology

Volumn 20, Issue 24, 2000, Pages 9113-9119

  Udalova, I A ^a   Richardson, A ^a   Denys, A ^a   Smith, C ^a   Ackerman, H ^a   Foxwell, B ^a   Kwiatkowski, D ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; SYNAPTOTAGMIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; GENE CONTROL; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REPORTER GENE;

ADENOVIRIDAE; ANIMALS; BINDING SITES; CELL FRACTIONATION; CELL LINE; CELLS, CULTURED; CLONING, MOLECULAR; COS CELLS; DIMERIZATION; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MONOCYTES; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0034459681     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.24.9113-9119.2000     Document Type: Article

References (27)

1. Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-κB p50
2. The NF-κB and IB proteins: New discoveries and insights
3. Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA
4. Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis
5. Efficient adenoviral infection with IB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-κB dependent
6. Endotoxin-responsive sequences control cachetin/tumor necrosis factor biosynthesis at the translational level
7. A simplified system for generating recombinant adenoviruses
8. Polymorphism of the 5′-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese
9. Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-κB1) but expressing p50
10. NF-κB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
11. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription
12. Selection of optimal κB/Rel DNA-binding motifs: Interaction of both subunits of NF-κB with DNA is required for transcriptional activation
13. Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: Distinct NF-κB binding pattern and enhancer activity in LPS activated murine macrophages
14. An HMG-like protein that can switch a transcriptional activator to a repressor
15. Distinct combinations of NF-κB subunits determine the specificity of transcriptional activation
16. KBF1 (p50 NF-κB homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells
17. The p65 subunit is responsible for the strong transcription activating potential of NF-κB
18. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
19. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
20. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
21. A common functional polymorphism (C→A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha
22. -308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter
23. Identification of the tel family members required for virus induction of the human beta interferon gene
24. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome
25. Complex NF-κB interactions at the distal tumor necrosis factor promoter region in human monocytes
26. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter
27. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes