Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-κB in leukocyte recruitment

Journal of Immunology

Volumn 167, Issue 3, 2001, Pages 1592-1600

  Alcamo, E ^a   Mizgerd, J P ^a   Horwitz, B H ^a   Bronson, R ^a   Beg, A A ^a   Scott, M ^a   Doerschuk, C M ^a   Hynes, R O ^a   Baltimore, D ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; RECEPTOR SUBTYPE; RNA; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEATH; GENE INDUCTION; GENE MUTATION; HEMATOPOIESIS; IMMUNE RESPONSE; INFECTION SENSITIVITY; LEUKOCYTE MIGRATION; MOUSE; NEUTROPHIL; NEWBORN; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FAMILY;

EID: 0035424999     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.3.1592     Document Type: Article

References (54)

1. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
2. NF-κB and Rel proteins in innate immunity
3. An ancient system of host defense
4. Pro-inflammatory signaling: Last pieces in the NF-κB puzzle?
5. Signal transduction through NF-κB
6. Rel/NF-κB/IκB family: Intimate tales of association and dissociation
7. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
8. Expression of RelB is required for the development of thymic medulla and dendritic cells
9. NF-κB RelA-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
10. Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
11. The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects
12. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells
13. Osteopetrosis in mice lacking NF-κB1 and NF-κB2
14. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
15. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
16. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NFκB/Rel family
17. -/- double-knockout mice
18. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
19. Regulation of immune responses by NF-κB/Rel transcription factor
20. The p65 subunit of NF-κB is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3
21. An essential role for NF-κB in preventing TNF-α-induced cell death
22. Signal-induced degradation of IκBα: Association with NF-κB and the PEST sequence in IκBα are not required
23. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
24. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
25. Severe liver degeneration in mice lacking the IκB kinase 2 gene
26. Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR1 double knockout mice
27. Mice deficient for the 55 kD tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
28. Activation of multiple NF-κB/Rel DNA-binding complexes by tumor necrosis factor
29. Effects of CD 18 deficiency on the emigration of murine neutrophils during pneumonia
30. Neutrophil emigration in the skin, lungs, and peritoneum: Different requirements for CD11/CD18 revealed by CD18-deficient mice
31. A critical role for the RelA subunit of nuclear factor κB in regulation of multiple immune-response genes and in Fas-induced cell death
32. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
33. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ε-deficient mice
34. Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections
35. Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: Elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival
36. Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats
37. Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation
38. Role of the intercellular adhesion molecule-1 (ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies and ICAM-1 mutant mice
39. Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-κB1) but expressing p50
40. Roles of tumor necrosis factor receptor signaling during murine Escherichia coli pneumonia
41. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
42. Role of the type I TNF receptor in lung inflammation after inhalation of endotoxin or Pseudomonas aeruginosa
43. TNF mediates lung leak, bur not neutrophil accumulation, in lungs of rats given IL-1 intratracheally
44. Combinatorial requirements for adhesion molecules in mediating neutrophil emigration during bacterial peritonitis in mice
45. CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits
46. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
47. Adhesion molecules and cellular biomechanical changes in acute lung injury: Giles F. Filley lecture
48. Innate immunity: The virtues of a nonclonal system of recognition
49. Seeking wisdom in innate immunity
50. Innate immunity
51. Myeloid development is selectively disrupted in PU.1 null mice
52. Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins
53. The genetic basis of chronic granulomatous disease
54. "The good, the bad, and the ugly:" The role of chemokines in models of human disease