-
1
-
-
0033600604
-
The beginning of the end: IκB kinase (IKK) and NF-κB activation
-
Karin, M. The beginning of the end: IκB kinase (IKK) and NF-κB activation. J. Biol. Chem. 274, 27339-27342 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27339-27342
-
-
Karin, M.1
-
2
-
-
0033537767
-
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
-
Hu, Y. et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284, 316-320 (1999).
-
(1999)
Science
, vol.284
, pp. 316-320
-
-
Hu, Y.1
-
3
-
-
0033537757
-
Limb and skin abnormalities in mice lacking IKKα
-
Takeda, K. et al. Limb and skin abnormalities in mice lacking IKKα. Science 284, 313-316 (1999).
-
(1999)
Science
, vol.284
, pp. 313-316
-
-
Takeda, K.1
-
4
-
-
0033119952
-
Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice
-
Tanaka, M. et al. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice. Immunity 10, 421-429 (1999).
-
(1999)
Immunity
, vol.10
, pp. 421-429
-
-
Tanaka, M.1
-
5
-
-
0033537739
-
Severe liver degeneration in mice lacking the IκB kinase 2 gene
-
Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.-F. & Verma, I. M. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284, 321-325 (1999).
-
(1999)
Science
, vol.284
, pp. 321-325
-
-
Li, Q.1
Van Antwerp, D.2
Mercurio, F.3
Lee, K.-F.4
Verma, I.M.5
-
6
-
-
0033563227
-
IKKI-deficient mice exhibit abnormal development of skin and skeleton
-
Li, Q. et al. IKKI-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 13, 1322-1328 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 1322-1328
-
-
Li, Q.1
-
7
-
-
0033532386
-
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
-
Li, Z. W. et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med. 189, 1839-1845 (1999).
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1839-1845
-
-
Li, Z.W.1
-
8
-
-
0033537719
-
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
-
Delhase, M., Hayakawa, M., Chen, Y. & Karin, M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284, 309-313 (1999).
-
(1999)
Science
, vol.284
, pp. 309-313
-
-
Delhase, M.1
Hayakawa, M.2
Chen, Y.3
Karin, M.4
-
9
-
-
0032483017
-
JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action
-
Karin, M. & Delhase, M. JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action. Proc. Natl Acad. Sci. USA 95, 9067-9069 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 9067-9069
-
-
Karin, M.1
Delhase, M.2
-
10
-
-
0032808084
-
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases
-
Shimada, T. et al. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int. lmmunol. 8, 1357-1362 (1999).
-
(1999)
Int. Lmmunol.
, vol.8
, pp. 1357-1362
-
-
Shimada, T.1
-
11
-
-
0032583947
-
NF-κB-inducing kinase activates IKK-α by phosphorylation of ser-176
-
Ling, L., Cao, Z. & Coeddel, D. V. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl Acad. Sci. (USA) 95, 3792-3797 (1998).
-
(1998)
Proc. Natl Acad. Sci. (USA)
, vol.95
, pp. 3792-3797
-
-
Ling, L.1
Cao, Z.2
Coeddel, D.V.3
-
12
-
-
0028929371
-
Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation
-
Brockman, J. A. et al. Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation. Mol. Cell. Biol. 15, 2809-2818 (1995).
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 2809-2818
-
-
Brockman, J.A.1
-
13
-
-
0028986075
-
Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation
-
Brown, K., Gerstberger, S., Carlson, L., Franzoso, G. & Siebenlist, U. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267, 1485-1488 (1995).
-
(1995)
Science
, vol.267
, pp. 1485-1488
-
-
Brown, K.1
Gerstberger, S.2
Carlson, L.3
Franzoso, G.4
Siebenlist, U.5
-
14
-
-
0028978032
-
Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli
-
Traencker, E. B.-M. et al. Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli. EMBO J. 14, 2876-2883 (1995).
-
(1995)
EMBO J.
, vol.14
, pp. 2876-2883
-
-
Traencker, E.B.-M.1
-
15
-
-
0029670083
-
Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
-
DiDonato, J. A. et al. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16, 1295-1304 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1295-1304
-
-
Didonato, J.A.1
-
16
-
-
17944401842
-
Identification of the receptor component of the IκBα-ubiquitin ligase
-
Yaron, A. et al. Identification of the receptor component of the IκBα-ubiquitin ligase. Nature 396, 590-594 (1998).
-
(1998)
Nature
, vol.396
, pp. 590-594
-
-
Yaron, A.1
-
17
-
-
13044317276
-
Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cullin/F-box protein FWD1
-
Hatakeyama, S. et al. Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cullin/F-box protein FWD1. Proc. Natl Acad. Sci. USA 96, 3859-3863 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 3859-3863
-
-
Hatakeyama, S.1
-
18
-
-
0030271387
-
NF-κB: Ten years after
-
Baeuerle, P. A. & Baltimore, D. NF-κB: ten years after. Cell 87, 13-20 (1996).
-
(1996)
Cell
, vol.87
, pp. 13-20
-
-
Baeuerle, P.A.1
Baltimore, D.2
-
19
-
-
0028971289
-
Rel/NF-κB/IκB family: Intimate tales of association and dissociation
-
Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D. & Miyamoto, S. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9, 2723-2735 (1995).
-
(1995)
Genes Dev.
, vol.9
, pp. 2723-2735
-
-
Verma, I.M.1
Stevenson, J.K.2
E, M.3
Van Antwerp, D.4
-
20
-
-
0029874138
-
The NF-κb and IκB proteins: New discoveries and insights
-
Baldwin, A. S. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683 (1996).
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 649-683
-
-
Baldwin, A.S.1
-
21
-
-
0030615201
-
Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
-
Barnes, P. J. & Karin, M. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336, 1066-1071 (1997).
-
(1997)
N. Engl. J. Med.
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
22
-
-
0026451081
-
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
-
Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614 (1992).
-
(1992)
Science
, vol.258
, pp. 607-614
-
-
Nishizuka, Y.1
-
23
-
-
0030609162
-
A selective ∈-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death
-
Gray, M. O., Karliner, J. S. & Mochly-Rosen, D. A selective ∈-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. J. Biol. Chem. 272, 30945-30951 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30945-30951
-
-
Gray, M.O.1
Karliner, J.S.2
Mochly-Rosen, D.3
-
24
-
-
0032508501
-
Evidence that protein kinase C∈ mediates phorbol ester inhibition of calphostin C- and tumor necrosis factor-α-induced apoptosis in u937 histiocytic lymphoma cells
-
Mayne, G. C. & Murray, A. W. Evidence that protein kinase C∈ mediates phorbol ester inhibition of calphostin C- and tumor necrosis factor-α-induced apoptosis in U937 histiocytic lymphoma cells. J. Biol. Chem. 273, 24115-24121 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24115-24121
-
-
Mayne, G.C.1
Murray, A.W.2
-
25
-
-
0030298294
-
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
-
Liu, Z. G., Hsu, H., Goeddel, D. V. & Karin, M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87, 565-576 (1996).
-
(1996)
Cell
, vol.87
, pp. 565-576
-
-
Liu, Z.G.1
D, V.2
Karin, M.3
-
26
-
-
0033485542
-
NF-κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
-
Pomerantz, J. L. & Baltimore, D. NF-κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 18, 6694-6704 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 6694-6704
-
-
Pomerantz, J.L.1
Baltimore, D.2
-
27
-
-
9044253707
-
Platelet-derived growth factor activates protein kinase C∈ through redundant and independent signaling pathways involving phospholipase Cγ or phosphatidylinositol 3-kinase
-
Moriya, S. et al. Platelet-derived growth factor activates protein kinase C∈ through redundant and independent signaling pathways involving phospholipase Cγ or phosphatidylinositol 3-kinase. Proc. Natl Acad. Sci. USA 93, 151-155 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 151-155
-
-
Moriya, S.1
-
28
-
-
0025259380
-
A mouse embryonic stem cell line showing pluripotency of differentiation in early embryos and ubiquitous beta-galactosidase expression
-
Suemori, H. et al. A mouse embryonic stem cell line showing pluripotency of differentiation in early embryos and ubiquitous beta-galactosidase expression. Cell Differ. Dev. 29, 181-186 (1990).
-
(1990)
Cell Differ. Dev.
, vol.29
, pp. 181-186
-
-
Suemori, H.1
-
29
-
-
0030610362
-
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
-
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. & Karin, M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548-554 (1997).
-
(1997)
Nature
, vol.388
, pp. 548-554
-
-
DiDonato, J.A.1
Hayakawa, M.2
Rothwarf, D.M.3
Zandi, E.4
Karin, M.5
-
30
-
-
0032101707
-
Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes
-
Werlen, G., Jacinto, E., Xia, Y. & Karin, M. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17, 3101-3111 (1997).
-
(1997)
EMBO J.
, vol.17
, pp. 3101-3111
-
-
Werlen, G.1
Jacinto, E.2
Xia, Y.3
Karin, M.4
|