Alymphoplasia is caused by a point mutation in the mouse gene encoding nf-κb-inducing kinase

Nature Genetics

Volumn 22, Issue 1, 1999, Pages 74-77

  Shinkura, Reiko ^a   Kitada, Kazuhiro ^a   Matsuda, Fumihiko ^a   Tashiro, Kei ^a   Ikuta, Koichi ^a   Suzuki, Misao ^b   Kogishi, Katsumi ^a   Serikawa, Tadao ^a   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL MODEL; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC COMPLEMENTATION; LYMPHATIC SYSTEM DISEASE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DNA, COMPLEMENTARY; HUMANS; LYMPH NODES; LYMPHOTOXIN BETA RECEPTOR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEYER'S PATCHES; PHENOTYPE; POINT MUTATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TUMOR NECROSIS FACTOR; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SPLEEN; THYMUS GLAND;

EID: 0032930861     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/8780     Document Type: Article

References (28)

1. Miyawaki, S. et al. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol. 24, 429-434 (1994).
2. Shinkura, R. et al. Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant. Int. Immunol. 8, 1067-1075 (1996).
3. Koike, R. et al. The splenic marginal zone is absent in alymphoplastic aly mutant mice, Eur J. Immunol. 26, 669-675 (1996).
4. Fütterer, A., Mink, K., Luz, A., Kosco-Vilbois, M.H. & Pfeffer, K. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9, 59-70 (1998).
5. Rennert, P.D., Browning, J.L., Mebius, R., Mackey, F. & Hochman, P.S. Surface lymphotoxin α/β complex is required for the development of peripheral lymphoid organs. J. Exp. Med. 184, 1999-2006 (1996).
6. Rennert, P.D., Browning, J.L. & Hochman, P.S. Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization. Int. Immunol. 9, 1627-1639 (1997).
7. De Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin a. Science 264, 703-707 (1994).
8. Banks, T.A. et al. Lymphotoxin-α-deficient mice: effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155, 1685-1693 (1995).
9. Koni, P.A. et al. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity 6, 491-500 (1997).
10. Eugster, H.-P. et al. Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice. Int. Immunol. 8, 23-36 (1996).
11. Kuramoto, T. et al. The alymphoplasia (aly) mutation co-segregates with the intercellular adhesion molecule-2 (lcam-2) on mouse chromosome 11. Int. Immunol. 6, 991-994 (1994).
12. Malinin, N.L., Boldin, M.P., Kovalenko, A.V. & Wallach, D. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385, 540-544 (1997).
13. Song, H.Y., Régnier, C.H., Kirschning, C.J., Goeddel, D.V. & Rothe, M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc. Natl Acad. Sci. USA 94, 9792-9796 (1997).
14. Cheng, G. et al. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267, 1494-1498 (1995).
15. Ishida, T. et al. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc. Natl Acad. Sci. USA 93, 9437-9442 (1996).
16. Duckett, C.S., Gedrich, R.W., Gilfillan, M.C. & Thompson, C.B. Induction of nuclear factor κB by the CD30 receptor is mediated by TRAF1 and TRAF2. Mol. Cell. Biol. 17, 1535-1542 (1997).
17. Lee, S.Y. et al. CD30/TNF receptor-associated factor interaction: NF-κB activation and binding specificity. Proc. Natl Acad. Sci. USA 93, 9699-9703 (1996).
18. Nakano, H. et al. TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor. J. Biol. Chem. 271, 14661-14664 (1996).
19. VanArsdale, T.L. et al. Lymphotoxin-β receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor κB. Proc. Natl Acad. Sci. USA 94, 2460-2465 (1997).
20. Force, W.R., Cheung, T.C. & Ware, C.F. Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lympnotoxin-β receptor. J. Biol. Chem. 272, 30835-30840 (1997).
21. Krajewska, M. et al. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Am. J. Pathol. 152, 1549-1561 (1998).
22. d gene. EMBO J. 2, 245-254 (1983).
23. Lin, X. et al. Molecular determinants of NF-κB-inducing kinase action. Mol. Cell. Biol. 18, 5899-5907 (1998).
24. Beutler, B., Milsark, I.W. & Cerami, A.C. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229, 869-871 (1985).
25. Nishi, M., Ishida, Y. & Honjo, T. Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice. Nature 331, 267-269 (1988).
26. Nakamura, T. et al. The murine lymphotoxin-β receptor cDNA: isolation by the signal sequence trap and chromosomal mapping. Genomics 30, 312-319 (1995).
27. Kosco, M.H., Pflugfelder, E. & Gray, D. Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. J. Immunol. 148, 2331-2339 (1992).
28. Schreiber, E., Mattias, P., Muller, M.M. & Schaffuer, W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419 (1989).