Protein and RNA export from the nucleus

Developmental Cell

Volumn 2, Issue 3, 2002, Pages 261-272

  Lei, Elissa P ^a   Silver, Pamela A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; KARYOPHERIN; MESSENGER RNA; PORIN; PROTEIN; RAN PROTEIN; RIBONUCLEOPROTEIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CYTOPLASM; DEVELOPMENTAL BIOLOGY; GENE CONTROL; INTRACELLULAR TRANSPORT; MACROMOLECULE; NONHUMAN; NUCLEAR PORE COMPLEX; PROTEIN TRANSPORT; RIBOSOME; RNA SPLICING; RNA TRANSPORT; TRANSPORT KINETICS;

ANIMALIA;

EID: 0036196670     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(02)00134-X     Document Type: Review

References (113)

1. Control of the nuclear localization of Extradenticle by competing nuclear import and export signals
2. Proteomic analysis of nucleoporin interacting proteins
3. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTF bearing RNA substrates
4. Identification of a 60S preribosomal particle that is closely linked to nuclear export
5. Cytoplasmic transport of ribosomal subunits microinjected into the Xenopus laevis oocyte nucleus: A generalized, facilitated process
6. Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import
7. Coupling RNA polymerase II transcription with pre-mRNA processing
8. The subcellular localization of PBX1 and EXD proteins depends on nuclear importa and export signals and is modulated by association with PREP1 and HTH
9. Protein ligands to HuR modulate its interaction with target mRNAs in vivo
10. Pre-mRNA processing factors are required for nuclear export
11. A nuclear 3′-5′ exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p
12. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
13. Selective nuclear export of viral mRNAs in influenza-virus-infected cells
14. Inefficient processing impairs release of RNA from the site of transcription
15. Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex
16. Transcription factor TFIID recruits factor CPSF for formation of 3′ end of mRNA
17. Regulated nuclear export of the homeodomain transcription factor Prospero
18. Mature mRNA 3′ end formation stimulates RNA export from the nucleus
19. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction
20. A nuclear AAA- type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits
21. Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p
22. Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock
23. Delineation of mRNA export pathways by the use of cell-permeable peptides
24. The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila
25. TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans
26. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
27. Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport
28. Composition and functional characterization of yeast 66S ribosome assembly intermediates
29. NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila
30. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture
31. Quality control of mRNA 3′-end processing is linked to the nuclear exosome
32. Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3′-end formation of nascent transcripts
33. NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae
34. Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit
35. Rat8p/ Dbp5p is a shuttling transport factor that interacts with Rat7p/ Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells
36. Role of polyadenylation in nucleocytoplasmic transport of mRNA
37. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA
38. A novel in vivo assay reveals inhibition of ribosomal nuclear export in ran-cycle and nucleoporin mutants
39. Mex67p mediates nuclear export of a variety of RNA polymerase II transcripts
40. Coupled transcription and translation within nuclei of mammalian cells
41. Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions
42. A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export
43. Nuclear export of different classes of RNA is mediated by specific factors
44. A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription
45. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation
46. Regulation of nuclear localization: A key to a door
47. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
48. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
49. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
50. GRC5 and NMD3 function in translational control of gene expression and interact genetically
51. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
52. Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex
53. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
54. Nucleocytoplasmic transport of ribosomes in a eukaryotic system: Is there a facilitated transport process?
55. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase
56. Small bristles is required for the morphogenesis of multiple tissue during Drosophila development
57. Uncoupling of the hnRNP Npl3p from mRNAs during the stress-induced block in mRNA export
58. hnRNP complexes: Composition, structure, and function
59. Squid hnRNP protein promotes apical cytoplasmic transport and localization of Drosophila pair-rule transcripts
60. The exon-exon junction complex provides a bindng platform for factors involved in mRNA export and nonsense-mediated mRNA decay
61. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
62. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export
63. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
64. Messanger RNAs are recruited for nuclear export durng transcription
65. mRNA export; travelling with DEAD box proteins
66. Spatial consequences of defective processing of specific yeast mRNAs revealed by fluorescent in situ hybridization
67. An exclusively nuclear RNA-binding protein affects asymmetric localization of ASH1 mRNA and Ash1p in yeast
68. Splicing is required for rapid and efficient export in metazoans
69. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly
70. Nuclear shutting of yeast scaffold Ste5 is required for its retruitment to the plasma membrane and activation of tha mating MAPK cascade
71. Nucleocytoplasmic transport: The soluble phase
72. A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway
73. Maturation and intranuclear transport of pre-ribosomes requires Noc. proteins
74. Importin 13: A novel mediator of nuclear import and export
75. The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosphila oogenesis
76. Nuclear export of the small ribosomal subunit requires the ran-GTPase cycle and certain nucleoporins
77. The balance between two isoforms of the Drosophila RNA-binding protein how controls tendon cell differentiation
78. Transport of proteins and RNAs in and out of the nucleus
79. Transportin: Nuclear transport receptor of a novel nuclear protein import pathway
80. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
81. A new view of mRNA export: Separating the wheat from the chaff
82. Kinetic analysis of translocation through nuclear pore complexes
83. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
84. The APC tumour suppressor has a nuclear export function
85. The yeast nuclear pore complex: Composition, architecture, and transport mechanism
86. The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
87. Regulation of mRNA export in response to stress in Saccharomyces cerevisiae
88. Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p
89. Nog2p, a putative GTPase associated with pre-60s subunits and required for late 60S maturation steps
90. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p
91. Ran-dependent signal-mediated nuclear import does not required GTP hydrolysis by Ran
92. RNA-Regulated TRA-1 nuclear export controls sexual fate
93. Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila
94. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
95. Biochemical analysis of + +Prospero protein during asymmetric cell division: Cortical Prospero is highly phosphorylated relative to nuclear Prospero
96. Factors affecting nuclear export of the 60S ribosomal subunit in vivo
97. The nuclear pore complex: From molecular architecture to functional dynamics
98. Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p
99. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
100. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
101. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p
102. Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export
103. Ribosome synthesis in Saccharomyces cerevisiae
104. A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes
105. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
106. Gatekeepers of the nucleus
107. Formation of Tap/NXT1 Heterodimers Activates Tap-Dependent Nuclear mRNA Export by Enhancing Recruitment to Nuclear Pore Complexes
108. Small bristles, the Drosophila ortholog of NXF-1 is essential for mRNA export throughout development
109. Curbing the nonsense: The activation and regulation of mRNA surveillance
110. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
111. Two closely related human nuclear export factors utilize entirely distinct export pathways
112. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins
113. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans