Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p

Nature

Volumn 413, Issue 6856, 2001, Pages 648-652

  Strasser K ^a   Hurt, E ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; MUTAGENESIS; PROTEINS; RNA;

NUCLEAR PORES;

NATURAL SCIENCES;

CARRIER PROTEIN; FUNGAL PROTEIN; GENE PRODUCT; HELICASE; MESSENGER RNA; NUCLEAR PROTEIN; NUCLEAR PROTEIN YRA1P; PROTEIN MEX67P; PROTEIN SUB2P; UNCLASSIFIED DRUG;

GENETICS; RNA;

ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENE OVEREXPRESSION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RNA SPLICING; SPLICEOSOME;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; BINDING SITES; BIOLOGICAL TRANSPORT; CELL NUCLEUS; FUNGAL PROTEINS; GENES, LETHAL; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0035846109     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35098113     Document Type: Article

References (18)

1. + RNA and nuclear pores
2. Yra1p, a conserved nuclear RNA binding protein, interacts directly with Mex67p and is required for mRNA export
3. Multiple roles for the yeast SUB2/γUAP56 gene in splicing
4. Identification and characterization of γUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56
5. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPase
6. Yra1, an essential Saccharomyces cerevisiae gene, encodes a novel nuclear protein with RNA annealing activity
7. Mex67p mediates the nuclear export of a variety of pol II transcripts
8. A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription
9. Identification of a regulated pathway for nuclear pre-mRNA turnover
10. REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
11. The economics of ribosome biosynthesis in yeast
12. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
13. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA
14. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRα enhancer function
15. A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins
16. Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA
17. A novel complex of nucleoporins, which includes Sec 13p and a Sec13p homolog, is essential for normal nuclear pores
18. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly