Control of the nuclear localization of Extradenticle by competing nuclear import and export signals

Genes and Development

Volumn 13, Issue 8, 1999, Pages 935-945

  Abu Shaar, Muna ^a   Ryoo, Hyung Don ^a   Mann, Richard S ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Drosophila; Extradenticle; Homothorax; Nuclear localization

Indexed keywords

ARTICLE; CELLULAR DISTRIBUTION; DROSOPHILA; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

NES;

EID: 0344436081     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.8.935     Document Type: Article

References (46)

1. Abu-Shaar, M. and R.S. Mann. 1998. Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development 125: 3821-3830.
2. Aspland, S.E. and R.A. White. 1997. Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila. Development 124: 741-747.
3. Blank, V., P. Kourilsky, and A. Israel. 1992. NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem. Sci. 17: 135-140.
4. Brand, A. and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
5. Briggs, L.J., D. Stein, J. Goltz, V.C. Corrigan, A. Efthymiadis, S. Hubner, and D.A. Jans. 1998. The cAMP-dependent protein kinase site (Ser312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction. J. Biol. Chem. 273: 22745-22752.
6. Burglin, T.R. and G. Ruvkun. 1992. New motif in PBX genes. Nat. Genet. 1: 319-320.
7. Casares, F. and R.S. Mann. 1998. Control of antennal versus leg development in Drosophila. Nature 392: 723-726.
8. Chang, C.P., Y. Jacobs, T. Nakamura, N.A. Jenkins, N.G. Copeland, and M.L. Cleary. 1997. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol. 17: 5679-5687.
9. Cho, K.W. and I.L. Blitz. 1998. BMPs, Smads and metalloproteases: Extracellular and intracellular modes of negative regulation. Curr. Opin. Genet. Dev. 8: 443-449.
10. Dingwall, C. and R.A. Laskey. 1991. Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16: 478-481.
11. Fischer, U., J. Huber, W.C. Boelens, I.W. Mattaj, and R. Luhrmann. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82: 475-483.
12. Fornerod, M., M. Ohno, M. Yoshida, and I.W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90: 1051-1060.
13. Fukuda, M., S. Asano, T. Nakamura, M. Adachi, M. Yoshida, M. Yanagida, and E. Nishida. 1997. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390: 308-311.
14. Gillespie, S.K. and S.A. Wasserman. 1994. Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll. Mol. Cell. Biol. 14: 3559-3568.
15. Gonzalez-Crespo, S. and G. Morata. 1996. Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite. Development 122: 3921-3928.
16. Gonzalez-Crespo, S., M. Abu-Shaar, M. Torres, C. Martínez-Arias, R.S. Mann, and G. Morata. 1998. Antagonism between extradenticle function and Hedgehog signalling in the development limb. Nature 394: 196-200.
17. Hoey, T. and U. Schindler. 1998. STAT structure and function in signaling. Curr. Opin. Genet. Dev. 8: 582-587.
18. Itoh, S., M. Landstrom, A. Hermansson, F. Itoh, C.H. Heldin, N.E. Heldin, and P. ten Dijke. 1998. Transforming growth factor betal induces nuclear export of inhibitory Smad7. J. Biol. Chem. 273: 29195-29201.
19. Jans, D.A., M.J. Ackermann, J.R. Bischoff, D.H. Beach, and R. Peters. 1991. p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins. J. Cell. Biol. 115: 1203-1212.
20. Johnson, P.R., R. Swanson, L. Rakhilina, and M. Hochstrasser. 1998. Degradation signal masking by heterodimerization of MATα2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway. Cell 94: 217-227.
21. Kamps, M.P., C. Murre, X.-h. Sun, and D. Baltimore. 1990. A new homeobox gene contributes the DNA binding domain of the t(1:19) translocation protein in pre-B ALL. Cell 60: 547-555.
22. Knoepfler, P., K. Calvo, H. Chen, S. Antonarakis, and M. Kamps. 1997. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. 94: 14553-14558.
23. Kudo, N., B. Wolff, T. Sekimoto, E.P. Schreiner, Y. Yoneda, M. Yanagida, S. Horinouchi, and M. Yoshida. 1998. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242: 540-547.
24. Kurant, E., C.-Y. Pai, R. Sharf, N. Halachmi, Y. Sun, and A. Salzberg. 1998. dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS. Development 125: 1037-1048.
25. Li, J., A.N. Meyer, and D.J. Donoghue. 1997. Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation. Proc. Natl. Acad. Sci. 94: 502-507.
26. Mann, R. and M. Abu-Shaar. 1996. Nuclear import of the homeodomain protein Extradenticle in response to Decapentaplegic and Wingless signalling. Nature 383: 630-633.
27. Mann, R.S. and M. Affolter. 1998. Hox proteins meet more partners. Curr. Opin. Genet. Dev. 8: 423-429.
28. Mardon, G., N.M. Solomon, and G.M. Rubin. 1994. dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development 120: 3473-3486.
29. Nakielny, S. and G. Dreyfuss. 1997. Nuclear export of proteins and RNAs. Curr. Opin. Cell Biol. 9: 420-429.
30. Nourse, J., J. Mellentin, N. Galili, J. Wilkinson, E. Stanbridge, S. Smith, and M. Cleary. 1990. Chromosomal translocation t(1: 19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60: 535-545.
31. Ossareh-Nazari, B., F. Bachelerie, and C. Dargemont. 1997. Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science 278: 141-144.
32. Otero, G.C., M.E. Harris, J.E. Donello, and T.J. Hope. 1998. Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus rev function but not the function of the hepatitis B virus posttranscriptional regulatory element. J. Virol. 72: 7593-7597.
33. Pai, C.-Y., T. Kuo, T. Jaw, E. Kurant, C. Chen, D. Bessarab, A. Salzberg, and Y. Sun. 1998. The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila. Genes & Dev. 12: 435-446.
34. Peifer, M. and E. Wieschaus. 1990. Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity. Genes & Dev. 4: 1209-1223.
35. Puri, P.L., L. Cimino, M. Fulco, C. Zimmerman, N.B. La Thangue, A. Giordano, A. Graessmann, and M. Levrero. 1998. Regulation of E2F4 mitogenic activity during terminal differentiation by its heterodimerization partners for nuclear translocation. Cancer Res. 58: 1325-1331.
36. Rauskolb, C., M. Peifer, and E. Wieschaus. 1993. extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell 74: 1-20.
37. Riddihough, G. and D. Ish-Horowicz. 1991. Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes. Genes & Dev. 5: 840-854.
38. Rieckhof, G., F. Casares, H.D. Ryoo, M. Abu-Shaar, and R.S. Mann. 1997. Nuclear translocation of Extradenticle requires homothorax, which encodes an Extradenticle-related homeodomain protein. Cell 91: 171-183.
39. Rihs, H.P., D.A. Jans, H. Fan, and R. Peters. 1991. The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen. EMBO J. 10: 633-639.
40. Roth, M.B., A.M. Zahler, and J.A. Stolk. 1991. A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. J. Cell Biol. 115: 587-596.
41. Shibasaki, F., E.R. Price, D. Milan, and F. McKeon. 1996. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382: 370-373.
42. Stade, K., C.S. Ford, C. Guthrie, and K. Weis. 1997. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90: 1041-1050.
43. Taagepera, S., D. McDonald, J.E. Loeb, L.L. Whitaker, A.K. McElroy, J.Y. Wang, and T.J. Hope. 1998. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc. Natl. Acad. Sci. 95: 7457-7462.
44. Timmerman, L.A., N.A. Clipstone, S.N. Ho, J.P. Northrop, and G.R. Crabtree. 1996. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 383: 837-840.
45. Wen, W., J.L. Meinkoth, R.Y. Tsien, and S.S. Taylor. 1995. Identification of a signal for rapid export of proteins from the nucleus. Cell 82: 463-473.
46. Wu, J. and S.M. Cohen. 1999. Proximodistal axis formation in the Drosophila leg: Subdivision into proximal and distal domains by Homothorax and Distal-less. Development 126: 109-117.